Conserved Protein Domain Family
Synaphin
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pfam05835: Synaphin (this model, PSSM-Id:283491 is obsolete and has been replaced by 461755)
Synaphin protein
This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerize into higher order structures. A peptide from the central, syntaxin binding domain of synaphin competitively inhibits these two proteins from interacting and prevents SNARE complexes from oligomerizing. It is thought that oligomerization of SNARE complexes into a higher order structure creates a SNARE scaffold for efficient, regulated fusion of synaptic vesicles. Synaphin promotes neuronal exocytosis by promoting interaction between the complementary syntaxin and synaptobrevin transmembrane regions that reside in opposing membranes prior to fusion.
Links
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Statistics
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PSSM-Id: 283491
Aligned: 27 rows
Threshold Bit Score: 87.0706
Created: 12-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P63040         1 MEFVMKQALGGATKDMGKML----GG-DEEKD---PDAA---KKEEERQEALRQAEEERKAKYAKMEAEREVMRQGIRDK 69  house mouse
CDS34380       2 ASFIAKQLIGNQLDSVKGAL----GDkKDEGG---SSGAr--EIDPEVEEALREAEQKRQEKHRKMEEEREAMRQDIRDK 72  Hymenolepis mic...
GAA37888       2 ASFIAKQLIGNQLDSVKGAL----GDkKDDDG---GSGAk--EIDPEVEAALREAEARREAKHQKMEEEREVMRQEIRDK 72  Clonorchis sine...
XP_003142100   2 ASFIMKQMVGGKLNEMKGGIdkltGDkDGEGG---EKTEs--gEDPEVVAARLEQEERRKERHRKMEREREKMRQDIRSK 76  eye worm
ERG82353       2 AGFVMKQMVGGKLNEMKGGLdkltGDnEGEGG---EKTEs--gEDPEVVAARLEQEERRKEKHRKMEQEREKMRQDIRAK 76  pig roundworm
XP_011417713   2 AAFIAKQMVGNQLKSVKGAI----GGgDKEGEgenKEDAgggGEDPEVEEMRREAERKRKEKHEKAEAEREELRQSIRDK 77  Pacific oyster
EFX87986       2 AAFVAKQMLGSKMNAVKG-L----GGnDSEDG---DTKDkddEAERERLEAIKEAEDRRKEKHRKMEVERENMRQDIRDK 73  common water flea
XP_009030122   2 tAFLAKQMLGNQLESVKGAL----GDkEKEEK---Ksd---dEEDPEILEAKREEEEKRKEKYRKIEEEREKMRQDIRTK 71  Helobdella robusta
NP_001156645   2 AAFVAKQVVGNKLNAVKGAV----GD-GGESA---EDKEknaEAERERLEAIREAEERRKEKHRKMEEEREKMRQEIRDK 73  pea aphid
XP_625223      2 AAFVAKQMVGNKLNAVKGAV-----GgEGGDE---DDKEkeeEAERERQEAIREAEERRKEKHRKMEEEREKMRQEIRDK 73  honey bee

P63040        70 YGIKKKEEREAEAQAAmeansegslTRPKK-----AIPPGCGDEPEEEdeSILDTVIKYlPGPLQDMFK 133 house mouse
CDS34380      73 YGIKKKEVEVDFDELmmnne-ggrvGRKRKtpaelAAEADRAAADEDSliGMLPEGMRDiASKVTEAPG 140 Hymenolepis microstoma
GAA37888      73 YGIKKKEEENPE---FdfsspegrlGRKRKtaaelAAEASAAEEAENSltNMLPENMRDiAHKVTEVPG 138 Clonorchis sinensis
XP_003142100  77 YNIQKKEDGISGIPFDtstdgrivgPSMKKtpqqiAQEM-EDDDSLIGqlG-LTEQVEKaKTAVNEALE 143 eye worm
ERG82353      77 YNITKKED-----GIPfdmtegrigSARKKtpeelAREMNADDDGIIGqlG-LTEQVEKaKTVVSgale 139 pig roundworm
XP_011417713  78 YGLKKKVPEE--ENMMlnnddggrvGRKKKtpaelAAEANADSDDDEFt---MPKNMDElKNKVQDIPQ 141 Pacific oyster
EFX87986      74 YNIKKKEEAP---EAEtlkepdnplMRKKKtpeelAKEAEEADQDE------LTKLKNTlETQVNEWKS 133 common water flea
XP_009030122  72 YNIKKKETNE---PAGndpslegrlGRKKKnpedpDADGTADVSEYENg---FPKTLNElTARVSQLPG 134 Helobdella robusta
NP_001156645  74 YNIKKKEELPEPVQeepa----nplMRKKKtp------eeLAKEAEMEeeDEFTKLKNTiETQVNELKS 132 pea aphid
XP_625223     74 YNIKKREEVQEMTQeep-----nplMRKKKtp------eeLAAEAEAEeeDEITKIKNAlDTHIQEIKa 131 honey bee
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