pfam06345: Drf_DAD (this model, PSSM-Id:283902 is obsolete and has been replaced by 428896)
DRF Autoregulatory Domain
This motif is found in Diaphanous-related formins. It binds the N-terminal GTPase-binding domain; this link is broken when GTP-bound Rho binds to the GBD and activates the protein. The addition of DAD to mammalian cells induces actin filament formation, stabilizes microtubules, and activates serum-response mediated transcription.
Jiyao W et al.(2023). "The conserved domain database in 2023.",