Conserved Protein Domain Family
RGM_N
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pfam06535: RGM_N (this model, PSSM-Id:284053 is obsolete and has been replaced by 461940)
Repulsive guidance molecule (RGM) N-terminus
This family consists of the N-terminal region of several mammalian and one bird sequence from Gallus gallus (Chicken). All of the mammalian proteins are hypothetical and have no known function but RGMA from the chicken is annotated as being a repulsive guidance molecule (RGM). RGM is a GPI-linked axon guidance molecule of the retinotectal system. RGM is repulsive for a subset of axons, those from the temporal half of the retina. Temporal retinal axons invade the anterior optic tectum in a superficial layer, and encounter RGM expressed in a gradient with increasing concentration along the anterior-posterior axis. Temporal axons are able to receive posterior-dependent information by sensing gradients or concentrations of guidance cues. Thus, RGM is likely to provide positional information for temporal axons invading the optic tectum in the stratum opticum.
Links
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Statistics
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PSSM-Id: 284053
Aligned: 32 rows
Threshold Bit Score: 203.645
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q1JQE7        39 CRIL-RCNSDFVAATLES--GVigggnKEGV---NTGY--CSALRSYALCTQRTA-RACRG--DLAYHSAVQGIEDLLIQ 107 zebrafish
XP_004067740  82 CRIQ-RCNANYVASTSLA--SG-----LQEDasvDVDY--CIALRAYALCVKRQA-RSCRG--DLVYHSAVFPIKELFFK 148 Japanese medaka
XP_005966628 114 CRIQ-KCTTDFVSLTSHL--NSa----VDGF---DSEF--CKALRAYAGCTQRTS-KACRG--NLVYHSAVLGISDLMSQ 178 chiru
XP_002602038  82 CRVT-KCNSEFVASTSAL--NPa----HQRD---LVLY--CRALRQATQCARRTA-RQCRG--DLHYHSTIRGFADLMQS 146 Florida lancelet
XP_002428231   8 CKAD-FCSSQYTESLDRE--KId----RPEP---TEAS--CKILRNFGKCLRMTA-KECHG--NIPYHSSIVMVKQLSKE 72  human body louse
XP_003728654  66 CDIL-WCSYQYEADTDPL--D-------PGP---YPDF--CRALQRYQRCVDRISpGSCRG--DLHYHSTKTVIPDLQRN 128 purple sea urchin
XP_011429195  64 CGMQ-LCYDRWRTAASAAdnGL-----IKPP---NGEIpaCVAHRTHLFCLIAEE-QHCRT--NLQYQMTKRGIIHKMKN 131 Pacific oyster
EFO15281      27 CMVD-YCADMYSERLDEG--GI-----LIGM---NAPY--CQIITDYIYCLSETN-RTCRG--NLKYHTLQTLLHRQRRE 90  eye worm
EFX90410      12 CKVD-SCTRQFQQAAMAS--GV-----RRG----SAAF--CVILRQYSDCLRSTA-RSCRG--HLAYHSTITLVQNWNGD 74  common water flea
XP_001623735  45 CQVQpKCTDPYVQ---------------REA---DTAFklCASLKLYKLCLDRIR-KQCRGsgGIYYNTVRTLVPVLMRN 105 starlet sea ane...

Q1JQE7       108 YRCPKA---------G-P-------------TA------------Q----------------------PQ-----Prp-- 123 zebrafish
XP_004067740 149 HNCSSD---------G-P-------------TS------------F----------------------AK-----S---- 162 Japanese medaka
XP_005966628 179 RNCSKD---------G-P-------------TS------------S----------------------TN-----P---- 192 chiru
XP_002602038 147 HNCTHV---------S-D-------------EP------------V----------------------PT-----R---- 160 Florida lancelet
XP_002428231  73 NNCEALigpektlpsP-P-------------LL------------R----------------------PS-----Iipkl 99  human body louse
XP_003728654 129 YECERVlree--nnpG-P-------------TR------------AvetttrpsrnggdndsdspgtnGR-----P---- 171 purple sea urchin
XP_011429195 132 DKCSAV---------G-D-------------AF------------N----------------------AS-----A---- 145 Pacific oyster
EFO15281      91 FSCNSF---------P-E-------------TM------------K----------------------P----------- 102 eye worm
EFX90410      75 SNCSYV---------G-G-------------ASgaggapaifnkdR----------------------PRnhdhhS---- 105 common water flea
XP_001623735 106 HKCDNV---------TlPekekgllnifkkrQM------------Q----------------------GN-----I---- 133 starlet sea ane...

Q1JQE7       124 ----lP---------QAPLSGDGCFYEKG---FIQreGRAPEYLHCGVFGDPHIRTFNEEFQTCAVQGAWPLIDNQYLYI 187 zebrafish
XP_004067740 163 -----Ps-------tPRPAASELCNYENRvlmSGSa-AQQKKYAHCGLFGDPHLRTFRDEFQTCKVEGAWPLIDNRFLSV 229 Japanese medaka
XP_005966628 193 -----------------EVTHDPCNYHRG---GGQn---PPNYLFCGLFGDPHLRTFKDHFQTCKVEGAWPLIDNNYLSV 249 chiru
XP_002602038 161 -----P---------TQEQLPQMCAYRGG---S------NTVYRHCGLFGDPHLRTFYDDFQTCKVDRAWPLIDNAYLAV 217 Florida lancelet
XP_002428231 100 pvntvP---------VSVVTQRSCTFLGK-----------NKFRYCGLFGDPHLKTFHSKYQTCKLKGAWPLIDNPYLAV 159 human body louse
XP_003728654 172 -----PffpdilsdaPETGGSQRCQYTGS-----------RSFRHCGLFGDPHLRTFDDLFQTCKVAGAWPLIYNDYLTA 235 purple sea urchin
XP_011429195 146 -----Vmdk----giIIRPNNLICTFRSK---YDK---TPIKYQHCGLFGDPHLRTFKDEFQTCKVEGAWSLVQNKYIMI 210 Pacific oyster
EFO15281     103 ----------------SNYVPIGCAFPTD---TA----PHTMQRYCGLFGSRHLRTLNGHFVTCARTGAYPLINNKHLLI 159 eye worm
EFX90410     106 -----P---------KVDDSP-SCTYQGR-----------PEVTHCSFYGDPHLVTFNGDFQTCKVAGAWPLIDNAYLAV 159 common water flea
XP_001623735 134 -----P---------PKPTVKPKCTRTKR---LY---SKSEEKKYCGLFGDPHLRTFGDAKQTCVVEGAWPLVENHFLIV 193 starlet sea ane...

Q1JQE7       188 QATSSPTR----ESSDTTILTEVTVIFQ 211 zebrafish
XP_004067740 230 QVTNVPVV----LGSSATATSKITVIFK 253 Japanese medaka
XP_005966628 250 QVTNVPVV----PGSSATATNKITIIFK 273 chiru
XP_002602038 218 QVTNVPVAvaasHGFTATATTKLTVIVK 245 Florida lancelet
XP_002428231 160 SVTNEPVI----ENSPATVTTKVTVIIK 183 human body louse
XP_003728654 236 QVTNVPLV----HGSGATATNKLTVIIK 259 purple sea urchin
XP_011429195 211 MVTNNPVK----DHGAATATSKLTVVIK 234 Pacific oyster
EFO15281     160 QITHSFL------GSGTTAISKVTVIIK 181 eye worm
EFX90410     160 SVTNEAVV----PGSSatattkitiiik 183 common water flea
XP_001623735 194 QVTNVPLV----DGSSATATNKITVIIQ 217 starlet sea anemone
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