1LW3,2YF0


Conserved Protein Domain Family
Myotub-related

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pfam06602: Myotub-related (this model, PSSM-Id:284109 is obsolete and has been replaced by 399535)
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Myotubularin-like phosphatase domain
This family represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associated with disease.
Statistics
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PSSM-Id: 284109
View PSSM: pfam06602
Aligned: 228 rows
Threshold Bit Score: 252.026
Threshold Setting Gi: 196001413
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1LW3_A        195 LFAFEYK--EVf--------pENGWKLYDPLLEYRRQ----------GIPNESWRITKINERYELCDTYPALLVVPANIP 254  human
Q7KSP6       1117 EFETQNNamPRllttkdvermREr----SYVQDWKRLgf-------dAESQRGFRISNANTSYATCRSYPAIIVAPVQCS 1185 fruit fly
NP_001135567  132 sYPFFFR--PPgy------slGHGWPRDTMENFYHKM----------RAETDDWRLSEVNLDFKICPSYPAKVIVPRICS 193  western clawe...
EJW88663      113 dYPFYYR--CPft------vlDNGWTAFDAEQEYAKLv---------IRCKDGWRISAVNKGFRVCSTYPEMVIVPKGIG 175  Wuchereria ba...
XP_002114932  109 hHAFYYN--PNfa------itEDGWKSFNLETEYARL----------TAGSRDFRVLEVNKGFKICSSYPERCLVPSSVN 170  Trichoplax ad...
XP_002073814 1131 eFETQNEtlPRllsskdiermREr----SYVQDWKRLgf-------dAESQRGFRISNANANYALCRSYPAIIVAPVQCS 1199 Drosophila wi...
XP_006004148 1066 tlsttMKssDKmtmsh--------vverACCRDYQRLglgtlsnslsRSKNEPFRISTVNRMYTVCRSYPSLLIVPQTIQ 1137 coelacanth
CCD80361       68 LYPFAYK--SNqssll-pvikTTDWPNNINE----------------LLSVGSWRISQLNENYSLCNSYPKTFIVPVKCD 128  Schistosoma m...
XP_012060555  174 LFAYDYKeaYYssldknvqlfRDi---sDWQNELKRTlc-------sDETKKGWRLSMVNAKFQLCPSLSQYVVVPASVT 243  Atta cephalotes
Q6F3C7         71 DYAFFYN--SPft------ilDDGWSAFDLEQEFARL----------MLSTDAFRISSVNENFAICPTYPEKLIVPKGIG 132  Caenorhabditi...
1LW3_A        255 DEELKRVASFRSRGRIPVLSWI-HpESQ---ATITRCS--------------------QPMVG-V--------------- 294  human
Q7KSP6       1186 DAAIMHLGRCFKGQRIPLPTWR-Ha-NG---ALLIRGG--------------------QPNSKsVigmlknttg------ 1234 fruit fly
NP_001135567  194 DETLQKAAAFRQAGRFPVLSYY-HsANQ---TALLRSA--------------------QPLFG-T--------------- 233  western clawe...
EJW88663      176 DDYLRISATFRDGGRFPILSFY-HgETK---SCLIRCG--------------------QPLVG-P--------------- 215  Wuchereria ba...
XP_002114932  171 ENIICKSAKFRYLGRFPIVSYI-YhAKK---AVLMRSS--------------------QPLSG-P--------------- 210  Trichoplax ad...
XP_002073814 1200 DATMTHLGRYFKGQRIPLPTWR-Hq-NG---ALLIRGA--------------------QPNSKsVigmlknttgantmt- 1253 Drosophila wi...
XP_006004148 1138 DSTIQRISRCNRQNRFPVVCWR----NSrtkAVLLRSAghsskgvsglfksqnpsatgQSQTD----------------- 1196 coelacanth
CCD80361      129 DQMIIESSRFRHGGRFPLLLYY-HkPRQ---TTLLITA--------------------EPLIN-Qstitnnqnttpllss 183  Schistosoma m...
XP_012060555  244 DSQLTDAARHFQGNRPPVWSWTsShG-----AALVKMS--------------------ELLPT-I--------------- 282  Atta cephalotes
Q6F3C7        133 DDYLKISATFREGGRFPVLSYF-HkETK---SPLVRCS--------------------QPLIG-P--------------- 172  Caenorhabditi...
1LW3_A        295 -------------------------------SGKRSKEDEKYLQA-IMDSna---------------------------- 314  human
Q7KSP6       1235 ------------------------sttnahhdvTHYPEQDKYFLA-LINTmpkltplalnqysgmnlsmssl-------- 1281 fruit fly
NP_001135567  234 -------------------------------APHHCKHDEALLNA-ALMEqs---------------------------- 253  western clawe...
EJW88663      216 -------------------------------TNRRCKEDETILNS-LLSSt----------------------------- 234  Wuchereria ba...
XP_002114932  211 -------------------------------NELRCKEDEKLLNAaIFGp------------------------------ 229  Trichoplax ad...
XP_002073814 1254 --------------------hhhhhhlhhphdvSHYHEQDKYFMA-LINTmpkmalnqysglnlsmssllghge------ 1306 Drosophila wi...
XP_006004148 1197 ---------------------------------SSSLEQEKYLQA-IINSmphysdasgrntlsgftsahmnssapsprs 1242 coelacanth
CCD80361      184 nssltsstksnnliinsssknsilpfsstfnT-GRCRSDEQLLSC-ILPDk----------------------------- 232  Schistosoma m...
XP_012060555  283 ---------------------------------TERMQENIMFEN-VRKS------------------------------ 298  Atta cephalotes
Q6F3C7        173 -------------------------------TNRRCREDETILNS-MITV------------------------------ 190  Caenorhabditi...
1LW3_A        315 -----------------------------------------------------------qsHKIFIFDA----------- 324  human
Q7KSP6       1282 ----------------------------------------mghsssddrqpltpelsrkhkNNLDISDGnkssqggkggt 1321 fruit fly
NP_001135567  254 --------------------------------------------------------------sGFIIDT----------- 260  western clawe...
EJW88663      235 -------------------------------------------------------------SKGVIVDT----------- 242  Wuchereria ba...
XP_002114932  230 -------------------------------------------------------------KHCYIVDT----------- 237  Trichoplax ad...
XP_002073814 1307 -------------------------------------dhhahhhhhhaqqpmtpevtrkheGKSSTMKGtsa-------- 1341 Drosophila wi...
XP_006004148 1243 rvisvsipkssvkvrgtpkgkwgsmrgssstrmssyipssevglrlaardttspqpnggpsEAHFLRQQ----------- 1311 coelacanth
CCD80361      233 -------------------------------------------------------------CRGVILDL----------- 240  Schistosoma m...
XP_012060555      --------------------------------------------------------------------------------      Atta cephalotes
Q6F3C7        191 -------------------------------------------------------------NRGYIIDT----------- 198  Caenorhabditi...
1LW3_A        325 ----------RPsvna----vanKAKgGGYESEDA-YQNAE-----LVFLDIHNIHVMRESLRKLKE-----IVYpniee 379  human
Q7KSP6       1322 mkgnpknslaHPfrkmrlyalgeKSQaKSNMNVDFcAD--------FIPVDYPDIRQSRPAFKKLIRac-mpSHNtnead 1392 fruit fly
NP_001135567  261 ----------RSaqea----kqaRNEgGGTESKSR-YRNWR-----VLHRPLERGHALQDSLVRLVV-----TCYdpsig 315  western clawe...
EJW88663      243 ----------RTkava----qsaKNKgGGCESQMF-YSQWK-----YIYGGTPRIKEIHDALAKLVE-----LCTetnis 297  Wuchereria ba...
XP_002114932  238 ----------RLtnya----tniKNKgGGVEPSCY-YPQWH-----RIHRGIENYNSLKDSLTKLVE-----ATSdfdcs 292  Trichoplax ad...
XP_002073814 1342 --------apLGfrkmrlyalgeKSQaKSNLNGDFcAD--------FIPVDYPDIRQSRSAFKKLIRac-mpSHIandad 1404 Drosophila wi...
XP_006004148 1312 ----------RAalyi----igdKSQlKGVKQDPLqQWE-------VVPIEVFDVRQVKASFKKLIKac-ipSCVptdpg 1369 coelacanth
CCD80361      241 ----------RTqnet----kkpQATsGLVEFEQY-YPQWR-----RVCRPLESTGNLIVTFRKFIY-----AAVagata 295  Schistosoma m...
XP_012060555  299 ----------HPq---------------------------KippvvIELNKEINVKLIAASFTKFINlctpeNIRqfwiq 341  Atta cephalotes
Q6F3C7        199 ----------RSkssa----taaKAKgGGAEPQGN-YRQWR-----YIQCPIPRQREIHDALTRMVD-----VCSerkvt 253  Caenorhabditi...
1LW3_A        380 t-hwlsnLESTHWLEHIKLILAGALRIA---------DKVESGKT---SVVVHSSDGWDRTAQLTSLAMLMLDGYYRTIR 446  human
Q7KSP6       1393 gqsfakmVEQSDWLQQISSLMQLSGAVV---------DLIDLQES---SVMLSLEDGSDVTAQLSSIAQLCLDPYYRSLD 1460 fruit fly
NP_001135567  316 mtrwlskLQAARWLSHVKEALSTAGLIA---------ECIERECA---NVLVHGEDGTDNTLLLTSLAQLILCPESRTMD 383  western clawe...
EJW88663      298 vdrwisrLGSCGWLQFVSDMLTCAATVA---------QCVHCEGSaevPVVVHGAEGTDSTLLVTSLAQLLLDSDSRTIR 368  Wuchereria ba...
XP_002114932  293 ssawlsrVSSSNWLNHVRSILNTACFVI---------GYLFDEGA---TVLVHGSDGMDATLQITSLAQIMIDQDCRTIR 360  Trichoplax ad...
XP_002073814 1405 gqsfakmVEQSDWLQQISSLLQLAGAVV---------DLIDLQES---SVMLSLEDGSDVTAQLSAIAQLCLDPYYRRLD 1472 Drosophila wi...
XP_006004148 1370 sgtyyrsLEESEWLSQLHKILQVSVLVV---------ELLD-TGS---SVLVSLEDGWDITTQVVSLVQLLSDPYYRTLE 1436 coelacanth
CCD80361      296 ldaldafAQ--------QQLQQEQCLLAekqrraskdQSLEEAKLrgsCVIVQSRKGTDRAILVASLIQIILNPESRTIQ 367  Schistosoma m...
XP_012060555  342 dnnfyslLENTKWLKYISYCLQKTVEVC---------DHLNLGI----SVILQEGAARDLCCVISSLAQLLLDHHFRTIV 408  Atta cephalotes
Q6F3C7        254 sdrwvsrVGQAGWLSSVAASLEAAANVA---------QCIYNERLeevPVVIHGGDGLDSTLIASSLAQILLDADARTIR 324  Caenorhabditi...
1LW3_A        447 GFEVLVEKEWLSFGHRFQLRVGhgdk--nhadA-DRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTF 523  human
Q7KSP6       1461 GFRVLVEKEWLAFGHRFAHRSNlkps--hantNiAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHSVSCRFRTF 1538 fruit fly
NP_001135567  384 GFQDLIEREWLQAGHPFQLRCAqsgw--sqsrAqQESPHFLLFLDCCWQLGRQFPRALEFNERFLCTLATHAYSSEYGSF 461  western clawe...
EJW88663      369 GFESLIEREWISAGHPFSYRCAhsafatggitGpHESPMFLCFLDCVWQVYQQFPCSFEFTEEFLIFLFEHAYASEFGSF 448  Wuchereria ba...
XP_002114932  361 GFQALIEREWLLGGHPFSSRCSklc----ntqDiSTSPVFLLFLDCVWQLQQQHPCFFEFNEEFLRVLGHKAYSSEFGTF 436  Trichoplax ad...
XP_002073814 1473 GFRVLVEKEWLAFGHRFAHRSNlkps--hastNiAFAPTFLQFLDVVHQLQRQFPMAFEFNDFYLRFLAYHVVSCRFRTF 1550 Drosophila wi...
XP_006004148 1437 GFRLLVEKEWLSFGHRFSHRGaqtl----asqSsGFAPVFLQFLDCVHQIHLQFPMEFEFSQYYLKFLAYHYVSNRFRTF 1512 coelacanth
CCD80361      368 GFQTLIDQTWLNAGHPFSDRCRnsaf--sikpPkDESPVFILFLDCVWQLLRQYPNSFEFTDELLCIIAKHAYFSEYGTF 445  Schistosoma m...
XP_012060555  409 GFQSLLQKEWVAGGHPFCDRLGhiv-----ktNsEKSPLFLLYLDCVWQLCQQYPTEFEFTETYLTTLWDAAHVSIFDTF 483  Atta cephalotes
Q6F3C7        325 GFESVIEREWICGGHPFSLRNNhcayaegtvtGpFESPVFLVFLDAVHQMIAQYPMSFEFDENFLIFLFEHAYASEFGSF 404  Caenorhabditi...
1LW3_A        524 LCNSEQQ 530  human
Q7KSP6       1539 LFDCELE 1545 fruit fly
NP_001135567  462 LCNNEKE 468  western clawed frog
EJW88663      449 LGNSEKE 455  Wuchereria bancrofti
XP_002114932  437 LYDSHAQ 443  Trichoplax adhaerens
XP_002073814 1551 LFDCELE 1557 Drosophila willistoni
XP_006004148 1513 LLDSDYE 1519 coelacanth
CCD80361      446 LGNSLQE 452  Schistosoma mansoni
XP_012060555  484 IFNCERD 490  Atta cephalotes
Q6F3C7        405 LGNCEKE 411  Caenorhabditis elegans
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