Conserved Protein Domain Family
MIG-14_Wnt-bd
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pfam06664: MIG-14_Wnt-bd (this model, PSSM-Id:284153 is obsolete and has been replaced by 461980)
Wnt-binding factor required for Wnt secretion
MIG-14 is a Wnt-binding factor. Newly synthesized EGL-20/Wnt binds to MIG-14 in the Golgi, targetting the Wnt to the cell membrane for secretion. AP-2-mediated endocytosis and retromer retrieval at the sorting endosome would recycle MIG-14 to the Golgi, where it can bind to EGL-20/Wnt for next cycle of secretion.
Links
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Statistics
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PSSM-Id: 284153
Aligned: 60 rows
Threshold Bit Score: 141.998
Created: 13-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q17DF1       192 ACEEFIVLHLGFLDYAHYIFTVRFYGLEGFHHRYNI-NG--VQFYFKTYNPAFTQIEIWFRF--IFLLFTFIVTCWfaH- 265 yellow fever mo...
XP_002679289 192 LCDPITLFYESHIRHPYYRIGVSFLNSRELYDNTLI-DPhfVKMEFESYNAAYSNWELGWRYsiIFITAPLCIAFIiaN- 269 Naegleria grube...
XP_002670886 243 gCSAITLFHSRVIRYSNYKMNLTILNLENVYRSGLLeNA--IETSLQSNNPQYSMYELGFRM--TFSVLSILHWIAflVv 318 Naegleria grube...
XP_001581117 155 LTTSITLFTDIILDYNKVEIDLTFD-----HPYTHF-SS--FILTYSIGTPDHAYFQIYFRF--LFSIVSAIFLALmlY- 223 Trichomonas vag...
EMD44783     181 yCNSLPIYEESFTNKLEYLITIQFIS--SKFNETDV-GE--FVLELSAISSHYTLFELCWKF--VFIFYSCIIVVIylF- 252 Entamoeba histo...
XP_001320784 147 tsDQILLYSSPLIEYDAIRIDIVVTDAE------HL-RA--AQVSHYLATIQHSYYEIYFRT--AFAIIEFMLLILfvF- 214 Trichomonas vag...
XP_001309127 155 ETYPIILYTQKLLNFDSIHFECTIDVPP------MY-TS--LTLRFVHGFTQYTIFQIYFKL--IFALIELIFLVLfvL- 222 Trichomonas vag...
XP_002681195 151 FCAPVIVYRERYISYPTYRIKVQIENLDVSSLLRS--DT--LFYRLETIRSDFTTFESVMRY--LYAAISIIIFIFysF- 223 Naegleria grube...
XP_001321077 155 NTNWHLIYFERIVDFTQVTAEIVVSGSELGFNTF--------VCEAIICSYSDSLVQIWIRI--VYSIVLFVVLRTfnA- 223 Trichomonas vag...
XP_001579036 144 vtdfaeifsglctDFDTLLIAVKLENKIESC------TG--ITIKWQYGHPHAPLLQFFVRC--LLAHQSIRCLIKylD- 212 Trichomonas vag...

Q17DF1       266 TLRKYP-IYDWSIEQKWMSVLLPLLVLYNNPLFPLIFLMSSWLPGMLDAILQATFLCALLMFWLCIYHGLR--QNErKLL 342 yellow fever mo...
XP_002679289 270 IIRSH--FVNWATEQKWIGLLLIFLVLYNNPIFALIFTAGNWAFSFINIVFIISFVCFLMFVVLVFTDSLVipQKDrSFL 347 Naegleria grube...
XP_002670886 319 TFWSQQ-LRNWHTAQKWLVVLLFLHFWYHDPLYPAMMWTGWEGFPVVDIILSVTFVYGFLLYLLIFFHSVFkaPQDrTFM 397 Naegleria grube...
XP_001581117 224 FLRGLE-VKLWHLEQKLTVPLVALLIFYNNPFYIFHVYNPSPVFVILDRILDSIFHSYMCFFILVLFDSLRy-KNRkTDR 301 Trichomonas vag...
EMD44783     253 IFRSFI-FKTWIFEVKWTFVLLIILVIQNNPIYSYQYTLDTFIPEFINVTVYSLFYVFLLFYVLITFEFYRygKGTkK-I 330 Entamoeba histo...
XP_001320784 215 SLRKVS-YSFWHLEQKLTLHLQFLSMLFNNPLIYLTITYPSKTGLILDILIKSIFTTYFRYFVLVLFDSLRy-KNRkTDP 292 Trichomonas vag...
XP_001309127 223 RLSTAQ-FKYWHLEQKLTCPLLLLSFLYNNIFEFFFVKHKSNSVVLLEILVNSLFSAYLKFFILVLFDSLRy-KNRkTDK 300 Trichomonas vag...
XP_002681195 224 ILLKYQtFRYAKTEQKWILFLLISLILFNNPLFIGEWLANDWILPFLNIIFQSTFISFFLLFLMVITASANthPKLrT-V 302 Naegleria grube...
XP_001321077 224 KLKTVD-VRH---EQSLSSGLLFTTIFLNDPAVIANYIRPTLGVTVFDSIMRSFYTGYLALFVFVVLGHc--gIKEkMMG 297 Trichomonas vag...
XP_001579036 213 FLSRSS-YRTWHLEQKLTFMLLILCVFAAHPLYILEFFDPSQLGIIFTIFTETLLFSYIKFFIIVLFDSLv-hRNCpKGC 290 Trichomonas vag...

Q17DF1       343 TFYVPKLIVIMPIWLCAVVL-ATWEKCNEMKDP---TYSH----FVDtgnynGFKMFFYISGAMYLLYLVLLILRAY--- 411 yellow fever mo...
XP_002679289 348 WFYIPKIVLVGILFVFVITT-FTYVRLQEQEDP---GYNLgivqGLSsy--qTLGIIVVLIMLVYIFVLIYYLMRVI--- 418 Naegleria grube...
XP_002670886 398 NFYLTKIIIVGIGYILTLIL-MIWSRVYNVANP---SSVD----ISSvpgyaYLLAANIVFLVLWGIDLAYYIFRAM--- 466 Naegleria grube...
XP_001581117 302 CFYIPKIIMCSIILIVYSIH-GIYDKLHLIAEH---NKNYn-----------TTAITSVAEMVVYLTFLLYTILSIL--- 363 Trichomonas vag...
EMD44783     331 KYWLPRIIFFVFFFAAVELV-FIYNKSVGLSDP---YYNP----LKDia-slVMAVIALVFVIAYIFWLIYILVRSF--- 398 Entamoeba histo...
XP_001320784 293 CFFVPKILFSFAMFAT------IYLNTMITELP---SYLP----FELsd--eVKKYIDTADTALFGVYLVWAAITTL--- 354 Trichomonas vag...
XP_001309127 301 CFFVPKIILCSIIYLADVVS-EIGFTVFDKK----------------------IIFMAYFNIVLFCGYIVWCIFCII--- 354 Trichomonas vag...
XP_002681195 303 NFYIWKSIFTLLFWCCLTVS-LLFERYETFSDRlmySYLI----DAPlf--gIIRIGVIGLGGLMLLYIFYQIFKTLggn 375 Naegleria grube...
XP_001321077 298 DFITNRLSIAAVVGLVTITR-EFLLDLAQIYNP---MMQI----VNAdy---yLKIVEYIILAGCAVGIVIETVRSS--- 363 Trichomonas vag...
XP_001579036 291 CFFFKRLFVMITDFIIVFAYnIICSDLLSLDLI---PFHI----TPKvs--qILHIGKIIISVFAAILIIISILRAT--- 358 Trichomonas vag...

Q17DF1       412 ------------------------SELRS--MP-YFDM-RLKF---LTLLMLFVLAISLTVTMCRFGFGILEdnfvakln 460 yellow fever mo...
XP_002679289 419 ------------------------EKHRMnlLP-KRNAwRSKViwfLTITMVIGTIVEIFLYVFSKD---WNs------- 463 Naegleria grube...
XP_002670886 467 ------------------------GAVGKlkAK-YSS--RFRVvgsFSFIVAAC---FIGLTIAGNGFRTDVq------- 509 Naegleria grube...
XP_001581117 364 ------------------------ISASRvdVT-E----RYKFniyLSSGLIAVIIMGACQALSSFKL-FSEs------- 406 Trichomonas vag...
EMD44783     399 ------------------------SDGIKlgKT-KRKL-RL-----FGVLTMISMMLFFMMLALSFFFGNQQt------- 440 Entamoeba histo...
XP_001320784 355 ------------------------FAGCQvdIT-E----RYKYviyIISGIAALALLATSELLFKFFKFFQDs------- 398 Trichomonas vag...
XP_001309127 355 ------------------------VASIQvdIT-E----RYKYiiyLVSGSVSIALIFLYGVIFSFLPKFKDs------- 398 Trichomonas vag...
XP_002681195 376 dfiqlaenlnntqplnqelkdklaMNIISysNTnQSSV-RFKYffiLTFLVLVVLGANMFSFLI---LNTSDn------- 444 Naegleria grube...
XP_001321077 364 ------------------------RRIDE-------IE-KFRLviyVIASSLALFILTSVMGLIGEKt------------ 399 Trichomonas vag...
XP_001579036 359 ------------------------YACDT-------SE-RYKFnayLTTVLIGLGFYILMLLCSRNKKI-GRt------- 398 Trichomonas vag...

Q17DF1       461 ttyksSAQFMCFYGLLNFYLYTMAYVYSPN 490 yellow fever mosquito
XP_002679289 464 -----SAQFLSYFMFYSLYVWLITILYWPS 488 Naegleria gruberi strain NEG-M
XP_002670886 510 -----SLTFLLLHGIVYVYFASLSFLLMPG 534 Naegleria gruberi strain NEG-M
XP_001581117 407 -----SLSFVIKFAVENIFSFLMVYFHWPY 431 Trichomonas vaginalis G3
EMD44783     441 -----LSISLTTTAFVNFFCTLLIVINIPH 465 Entamoeba histolytica KU27
XP_001320784 399 -----SLQFVEQFSIYNVFSMLMVYFHWPf 423 Trichomonas vaginalis G3
XP_001309127 399 -----ALRFVGVYSIQNVFVLLMAYFHWPY 423 Trichomonas vaginalis G3
XP_002681195 445 -----AVQYLGVFPLLNFYCIMLAIYFLPS 469 Naegleria gruberi strain NEG-M
XP_001321077 400 -----TLKFLATFGSANALAFAMTYAHYPf 424 Trichomonas vaginalis G3
XP_001579036 399 -----NFGFILYYAILIFLVNIFSYLHSPY 423 Trichomonas vaginalis G3
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