Conserved Protein Domain Family
Elongin_A

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pfam06881: Elongin_A (this model, PSSM-Id:284333 is obsolete and has been replaced by 399694)
RNA polymerase II transcription factor SIII (Elongin) subunit A
This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.
Statistics
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PSSM-Id: 284333
View PSSM: pfam06881
Aligned: 120 rows
Threshold Bit Score: 77.1978
Threshold Setting Gi: 470249967
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2HDX4        42 IQSLGDIPPCYLDPILQAvKSAEQLHIIEINSYDIYDETEKHWKRIIKKDFPILa--NR-HDYv---PQN----RkS--- 108 Chaetomium glob...
O59671        19 IDDIGDCPFELVKPILEK-ARPEHLIDLEEKSPHLKVDTQPLWKDHVLRDFGLEl--QK-RTIlnniD--------D--- 83  Schizosaccharom...
Q5KCI4       116 iWDIGDLEYSLVKPFIDE-VPMEQLAEIEANSPHIKKDTDWLYELFMLQDYRLFh--ER-CRErqgePRT----T-G--- 183 Cryptococcus ne...
EPY49632      19 IEDIGDYPYALLEPILER-APPDRLHLLEERSPHIKQESQSLWKLHVLRDFALEl--QQfKAPl---PSI----Td---- 84  Schizosaccharom...
XP_002171819  21 IEDLGDHPFSLVEPILAC-ARPDHLIRLEQNSPHLRDDTQGLWKVHVYREFGLDi--TD-QDT-----SN----IqD--- 84  Schizosaccharom...
KDE06957      62 ITDIGDCSYDLIKNILAL-FPAEQLHLIETRSPHISEHTGPLWKKLCVKDFVNIriqVE-DGTm---KHE----PaS--- 129 Microbotryum vi...
XP_007403663  20 LKDVGNCVYELIRPVLFA-CPPDQLAEIEDLSPHLMLESDEIWLLHLRRDFPNEs--KP-QATr---TIE----PePnse 88  Melampsora lari...
EMS24994      35 VTDVGDTPYDLISTLLPH-STAPQLLEIEANSPHIAQHTNHIWRDLCVHEFIEVr--KA-VEDg---RMKkedePaS--- 104 Rhodosporidium ...
XP_006955998  20 LDNIGDVPYSLIKDILFK-CHHNQLLKIEENSPELIKYDDEIWFQLFKSTFIKQf--QD-LT------QP----PsS--- 82  Wallemia sebi C...
GAA97800      21 LQNVGSAHYQDIEFALRR-CSAQQLACIEQHSPHLLRDTHALWHALNQADFGDDs--EA-YTPl---I--------D--- 82  Mixia osmundae ...
Q2HDX4       109 -------------------WHKIYNKYKQLDNEQLAAATEKLMQGFAVHTQEKQSRAS 147 Chaetomium globosum CBS 148.51
O59671        84 -------------------WRGLYGKLKKKRNAHYNVASAKLRSAYTKLEQSKQNKRi 122 Schizosaccharomyces pombe 972h-
Q5KCI4       184 -------------------WRKMYKKAKEDAAERQLQAADRVAARYKQLEEEKKSKSI 222 Cryptococcus neoformans
EPY49632      85 -------------------WRSLYQRLKKRRNTQYNEASEKLRNAYTKLEQTKQTKRI 123 Schizosaccharomyces cryophilus OY26
XP_002171819  85 -------------------WRRAYEDFKKRRNAQYNLASKKLRSAYTKLEQNKQHKRI 123 Schizosaccharomyces japonicus yFS275
KDE06957     130 -------------------WRDLHVEETKRRDAKMEAVQARMRTQYKGYSEGRATTnv 168 Microbotryum violaceum p1A1 Lamole
XP_007403663  89 pyptqtinpytnepidlpiHRIQYFTIKQSKAKALANASARLRERTQANRSEFSKRKA 146 Melampsora larici-populina 98AG31
EMS24994     105 -------------------WREQYAEEEVKREVKMQAILSKMRGRYEDYKEGRASTQl 143 Rhodosporidium toruloides NP11
XP_006955998  83 -------------------WRDLFLQEQTNQLNKLNKASNNLKLNQKQLELDKLNKQT 121 Wallemia sebi CBS 633.66
GAA97800      83 -------------------YRARYVAAEANIERKRQVTSEKLKRQTADLEAHRKAHTT 121 Mixia osmundae IAM 14324
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