4H4P,1YQZ,1Y56,2C3C,1H6V,4B1B,3DGH,1GRA,1EBD,1LVL,3ITJ


Conserved Protein Domain Family
Pyr_redox_2

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pfam07992: Pyr_redox_2 (this model, PSSM-Id:285266 is obsolete and has been replaced by 400379)
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Pyridine nucleotide-disulphide oxidoreductase
This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.
Statistics
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PSSM-Id: 285266
View PSSM: pfam07992
Aligned: 135 rows
Threshold Bit Score: 73.0871
Threshold Setting Gi: 73535574
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4H4P_A         8 APVVVLGAGLASVSFVAELRQAgyQGLITVVgDEAERPYDRPPLs---kDFMAHGDaeki-----------rldcKRAPE 73  Acidovorax sp. ...
Q58931         3 HDTIIIGAGPGGLTAGIYAMR---GKLNALC-IEKENAGGRIAEa---gIVENYPGfeeirgyel-aekfknhaeKFK-- 72  Methanocaldococ...
O28718         2 YDVAIIGGGPAGLTAALYSARY--GLKTVFF--ETVDPVSQLSLa---aKIENYPGfegsgmel----lekmkeqAVKAG 70  Archaeoglobus f...
O66790        13 YDVIIIGAGPAGTTAAIYTARA--GWKTLVL-YRAE-ADGALGVt---qKIENYPGvpgplsgyellkimreqakSFGAE 85  Aquifex aeolicu...
WP_010909042  12 HEVIVIGSGPAGYTAALYAAR---AQLTPLV-FEGTSFGGALMTt---tEVENYPGfrngitgpelmddmreqalRFGAE 84  Mycobacterium l...
WP_002656440  26 EDVIIVGSGPAGLTAGIYSVMS--NYK-AAI-LEGPEPGGQLTTt---tEVYNYPGfkngisgrnlmlnmreqvvNLGAK 98  Lyme disease sp...
WP_003447690   7 LDLVIIGAGPAGLTAAIYAIR---AKLNTLV-LENELVGGQIREt---yTVENFPGfnvisgadl-adkmeehaaSIGVN 78  Clostridium pas...
WP_002266050 209 FDVLVIGGGPAGNSAAIYAARK--GVK-TGL-LAETM-GGQVMEt---vGIENMIGtpyvegpql-maqveehtkSYSVD 279 Streptococcus m...
ELC22033     223 YDVLIVGSGPAGAAAAIYSARK--GIRTGLM---GERFGGQILDt---vDIENYISvpktegqkl-agalkvhvdEYDVD 293 Escherichia col...
WP_003234643   8 YDVTIIGGGPIGLFTAFYCGMR--ELKTKVI-EFLPKLGGKVSLffpekIIRDIGGipgiagkql-ieqlkeqaaTFDPD 83  Bacillus subtilis
4H4P_A        74 -VEWLLGvtaq--sfdPQAh-TVALsdgr--tlpyGTLVLATG-AAPRALpTLQ-GAtmp---vhTLRTLEDARRIQAgl 142 Acidovorax sp. ...
Q58931        73 -LPIIYDevi---kieTKEr-PFKVitkns-eyltKTIVIATG-TKPKKL-----GLnedkfigrGISYCTMCDAFFYln 140 Methanocaldococ...
O28718        71 -AEWKLEkver--verNGE--TFTViaegg-eyeaKAIIVATG-GKHKEA-GIE-GEsaf--igrGVSYCATCDG--Nff 137 Archaeoglobus f...
O66790        86 fVRGKVIat-----dlNSDpkKVYTidgr--efrgKTIIVASG-AMERAN-KFK-GEeef--lgrGVSYCGVCDAAFFkd 153 Aquifex aeolicu...
WP_010909042  85 lRTEDVEsv-----slRGPikSVVTaegq--tyqaRAVILAMG-TSVRYL-QIP-GEqel--lgrGVSACATCDGSFFrg 152 Mycobacterium l...
WP_002656440  99 -T-FPETvfs----ikRKGn-IFYLyteny-iyksKAVIIAVG-SKPKKL-ETLkNSglf--wnkGISVCAICDGHlfk- 165 Lyme disease sp...
WP_003447690  79 -IDQFSNiek---iklSDDe-KIIEtedv--iykvKALIIATG-AKSRRL-PIP-EEekl--hgkVIHYCELCDGALYqg 146 Clostridium pas...
WP_002266050 280 -IMKAPRak-----siQKTd-LVEVeldngahlkaKTAVLALG-AKWRKI-NVP-GEkef--fnkGVTYCPHCDGPlft- 346 Streptococcus m...
ELC22033     294 vIDSQSAsklipaaveGGLh-QIETasga--vlkaRSIIVATG-AKWRNM-NVP-GEdqy--rtkGVTYCPHCDGPlfk- 364 Escherichia col...
WP_003234643  84 -IVLNQRvtgf-erldDGT--IVLTgsegk-khytRTVILACGmGTLEVN-EFD-SEdaa--ryaGKNLHYGVEKLDAfk 154 Bacillus subtilis
4H4P_A       143 rpqsRLLIVGGGVIGLELAATARTA-GVHVSLVQTKPRLMsraapATLADFVARYHAAQ-GVDLRfERSV-TGSvdgV-- 217 Acidovorax sp. ...
Q58931       141 ---keVIVIGRDTPAIMSAINLKDI-AKKVIVITDKSEL------KAAESIMLDKLKEAnNVEIIyNAKPlEIVgeeRae 210 Methanocaldococ...
O28718       138 r-gkKVIVYGSGKEAIEDAIYLHDI-GCEVTIVSRTPSFR-------AEKALVEEVEKR-GIPVHySTTIrKIIgsgKve 207 Archaeoglobus f...
O66790       154 ---qpVAVIGDDDYAIEEAEFIARF-ANKVFFVVPGSKIK-------APPEVIEHFEKLpNVEILlRHRPiEIVgdqVvk 222 Aquifex aeolicu...
WP_010909042 153 ---qdIAVIGGGDSAMEEALFLTRF-ARSVTLVHRRDEFR-------ASKIMLGRARNNdKIKFItNHTVvAVNgytTvt 221 Mycobacterium l...
WP_002656440 166 --gkRVAVIGGGNTALSESIYLSKLvDK-VYLIVRKNNLR-------AIAMLRDSVAKLpNIEILyNSEAiEVDgksSvs 235 Lyme disease sp...
WP_003447690 147 ---kdLVVVGGGNSAVEAAIFLTKY-ARNITIVHQFDYLQ-------AQKYSQDELFKHkNVKIIwDSEIrNIVgenEie 215 Clostridium pas...
WP_002266050 347 --dkKVAVIGGGNSGLEAAIDLAGL-ASHVYILEFLPELK-------ADKILQDRAEALdNITILtNVATkEIIgndHve 416 Streptococcus m...
ELC22033     365 --gkRVAVIGGGNSGVEAAIDLAGI-VEHVTLLEFAPEMK-------ADQVLQDKLRSLkNVDIIlNAQTtEVKgdgSkv 434 Escherichia col...
WP_003234643 155 --gkRVVISGGGDTAVDWANELEPI-AASVTVVHRREEFG-------GMESSVTKMKQS-SVRVLtPYRLeQLNgdeEgi 223 Bacillus subtilis
4H4P_A       218 -------VLLDDGTRIAADMVVVGI-GVLANDalaraagla--cddgifvdAYGRtT-CPDVYALGDvtrqrnplsgrfe 286 Acidovorax sp. ...
Q58931       211 gv---kisVNGKEEIIKADGIFISL-GHVPNTeflkdsgieldkkgfiktdENCRtN-IDGIYAVGDvr----------g 275 Methanocaldococ...
O28718       208 kv-vaynREKKEEFEIEADGIFVAI-GMRPATdvvaelgverdsmgyikvdKEQRtN-VEGVFAAGDcc---------dn 275 Archaeoglobus f...
O66790       223 gi-klkdLEKKEEKLLEVNGVFIFLgGTKPSVdflmgqvem-tegdcivvnEEMMtS-VPGVFAAGDvl---------cn 290 Aquifex aeolicu...
WP_010909042 222 gl-rlrnTTTGEETTLVVTGVFVAI-GHEPRSslvsdvvdi-dpdgyvlvkGRTTsTsMDGVFAAGDlv---------dr 289 Mycobacterium l...
WP_002656440 236 sv-kifnKKDNVVYELEVSAVFMAV-GYKPNTeflkgfldl-deegfivtkDVVKtS-VDGVFSCGDvs---------nk 302 Lyme disease sp...
WP_003447690 216 ki-vvenVKTKQKTELKADGVFVYI-GYEPKTelfkdsini-nkwgyietdENMEtN-IKGVFAAGDvr---------sk 282 Clostridium pas...
WP_002266050 417 gl-rysdRTTNEEYLLDLEGVFVQI-GLVPSTdwlkdsglalnekgeiivaKDGAtN-IPAIFAAGDct---------ds 484 Streptococcus m...
ELC22033     435 vgleyrdRVSGDIHNIELAGIFVQI-GLLPNTnwlegaver-nrmgeiiidAKCEtN-VKGVFAAGDct---------tv 502 Escherichia col...
WP_003234643 224 ksvtvchTESGQRKDIEIDELIINH-GFKIDLgpmmewgle-ieegrvkadRHMRtN-LPGVFVAGDaaf-------yes 293 Bacillus subtilis
4H4P_A       287 RIETWSNAQNQG 298 Acidovorax sp. KKS102
Q58931       276 GVMQVAKAVGDG 287 Methanocaldococcus jannaschii DSM 2661
O28718       276 PLKQVVTACGDG 287 Archaeoglobus fulgidus
O66790       291 EVKQAVVAAAMG 302 Aquifex aeolicus VF5
WP_010909042 290 TYRQAITAAGSG 301 Mycobacterium leprae
WP_002656440 303 LYAQAITAAAEG 314 Lyme disease spirochete
WP_003447690 283 LIRQLTTAVSDG 294 Clostridium pasteurianum
WP_002266050 485 AYKQIIISMGSG 496 Streptococcus mutans
ELC22033     503 PYKQIIIATGEG 514 Escherichia coli KTE11
WP_003234643 294 KLRLIAGGFTEG 305 Bacillus subtilis
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