Conserved Protein Domain Family
SCA7

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pfam08313: SCA7 (this model, PSSM-Id:285508 is obsolete and has been replaced by 462422)
SCA7, zinc-binding domain
This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.
Statistics
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PSSM-Id: 285508
Aligned: 44 rows
Threshold Bit Score: 73.0211
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CCY0         16 KKKKEKSTPKEKPPVDVEKQCGVPLP-NGDLCARSLTCKSHSMGAKRAVQGRSQPYDVLLASYQKKN 81   Yarrowia lipolytica
XP_002422675  252 krdkkkSERKADKIYDPDKHCGVIND-NGKPCVRSILCKVHQVALKRAVPNRTMPYDMLIKILKNQN 317  human body louse
XP_008073389   32 SNSDAKKTNKVKKVFSVDRYCAVP-E-NGVPCKNSLTCRLHSLEQKNKVQGRVYPVEDLIRIWKREK 96   Vavraia culicis subsp. flo...
XP_005991766  271 knGHKSYKKISRKECDLKRHCGVVNPdTKTACTRLLTCKIHSVHQRREVLGRPKDFDQLVSELKAAS 337  coelacanth
XP_003511011  197 rlpPKTHRKMARKEFDLNRQCGVINPeTKKICTRLLTCKIHSVHQRREVPGRTKDFDVLVAELKASS 263  Chinese hamster
XP_002602920  206 sfdKERKIPLKDREYDPNKHCGVWLPdMKKPCTRSLTCKTHALSLRRAVPQRRKPFDELLAEHKARA 272  Florida lancelet
XP_781769     395 tvKSDKNVPCKDRRYDPDKHCGVWSDeHKRHCTRSLTCKTHSLSLRRAVQGRRLPFNELLAEHKARS 461  purple sea urchin
EHJ79216      340 SRKSSKTKANNQREYDPNKHCGVVTAeNPKPCTRSLTCKAHALSLRRTVDGRSKPFDTLLAEHRASR 406  monarch butterfly
XP_006615264  201 KRLKTDRSLLKDREYDPDRHCGVWNEeTGKPCTRSLTCKAHTVSLRRTVVGRSKTFDKLLAEHRASK 267  giant honeybee
EFA10966      210 HKKSKKSSTKALREYDPDIHCGVVDG-LKGPCTRSITCSNHKIQLRKSVPGRSKNIHVLIAEKKAAK 275  red flour beetle
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