Conserved Protein Domain Family
Protocadherin
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pfam08374: Protocadherin (this model, PSSM-Id:285562 is obsolete and has been replaced by 462451)
Protocadherin
The structure of protocadherins is similar to that of classic cadherins (pfam00028), but particularly on the cytoplasmic domains they also have some unique features. They are expressed in a variety of organizms and are found in high concentrations in the brain where they seem to be localized mainly at cell-cell contact sites. Their expression seems to be developmentally regulated.
Links
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Statistics
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PSSM-Id: 285562
Aligned: 17 rows
Threshold Bit Score: 246.939
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAG11168      969 SLANASLVEAQIARSLAA-PLSLDIAGDPDSDrsLGKQRLSVAIGVLAGAAAVILVILLVVTARQCGAQ-GKNGYEAGK- 1045 spotted green...
CAG01546      772 TISNVSLVEALVGHSLYT-PLDRDIAGDPDNG--FAAHRSNILFGSLAGVAGVVLLILVVVFIRHRIQReTKSGYQAGK- 847  spotted green...
XP_006631963  780 TINNVTLVESLVGHSLYT-PLDTDIAGDPDYR--HAAQRSNILYGSLAGIAGVILVIVIVVVIRYHLQKeAKSGYQAGK- 855  spotted gar
XP_007507570  868 SLHNSSFVDELLRRARGK-TRNREV-EKTDVAntINSDYIKYIIAIISGSMTAVLTIVIAAILR-CRHF---PGFKA-R- 939  gray short-ta...
XP_012408812  775 TLYNSTFVDELLRRNRGRfSVTHRVQKTDVASp-SSSDYIKYIIAIISGSMTAVLTIVIAALLR-CRRF---PRFRGAR- 848  Tasmanian devil
XP_700763     787 TIGNVSHVEGLVGHSLYT-PLEMDIAGDPDYS--RDPH-SNILFAVLGGFSVVILIIVVAMIIRHLVLKeNKSGYQAGK- 861  zebrafish
ACF95733      317 TAGNASYIYDLIRRTMET-PLDRNI-GDSSQPy-QNEDYLTIMIAIVAGAMVVIVVIFVTVLVR-CRHA---SRFKAAQr 389  domestic ferret
XP_003970301  782 TVSNATFIQEQLRKSMET-PLDRNI-GDSEVTa-QANGYVIVVIAIIAGTMTVILVIFVTALVR-CRQT---PRHKVVQk 854  torafugu
EHB13576      742 SVSNVTQIHELVHKSIET-PVTQNI-ETADASl-TTSDYVKIMVAIIAGTITVILIIFLTAVVR-CRQS---PQLKSAQk 814  naked mole-rat
XP_012906122  612 SVTNATWIHELVH-NIET-PVTPNI-ETTDASs-PTSDYVKIMVAIIAGTITVILVIFITAVVR-CHQS---PHLKASQk 683  domestic ferret

CAG11168     1046 -KEpEEDFFSPsgaqpqvSRGRGSDRG-----RKPRRDKRTgssggvsagggkS-------------DRSLYSGIVTvng 1106 spotted green...
CAG01546      848 -KE-TKDLYAP-------KQAPKNAKG-----KRGRKGKPQ------------KppkplgedeevslQKSLKFNLdg--- 898  spotted green...
XP_006631963  856 -KE-TKDLYAP-------KQGPKSSKG-----KKGKKGKAP------------KpakpieedeeaslQKTLKFNLINdg- 908  spotted gar
XP_007507570  940 -KQ-NSEWVTP-------NPANSETIT-----L--TTTDIG------------G-------------ANSVIVNLVSlse 978  gray short-ta...
XP_012408812  849 -KQ-NSEWVTP-------NPANSEAIT-----I--STNDNR------------G-------------PNNVILNLVSfae 887  Tasmanian devil
XP_700763     862 -KE-TKDLYAP-------KPGPKSNKN-----KKAKKSKAP------------KpanpseedeggtlQKGLKFNLMNen- 914  zebrafish
ACF95733      390 sKQ-GAEWMSP-------NQENKQn-------KKKKRKKRK------------S-------------PKSSLLNFVTiee 429  domestic ferret
XP_003970301  855 gKQ-SGEWVSP-------NQENRQIk------KKKKKRKKR------------S-------------PKSLLLNFVTide 895  torafugu
EHB13576      815 nKQ-NSEWVTP-------NPENRQMRVm---kKKKRKMKTH------------A-------------PQNLLLNFVTiek 858  naked mole-rat
XP_012906122  684 nKQ-NSEWVTP-------NPENRQMVMmmmkkKKKKKKKKH------------Apknlllnfvtie-------------- 729  domestic ferret

CAG11168     1107 lrrhanddeEEElsS--ASDRLaa---------------rYCVVDDDPGsprmgsgrrhqsSPDLARHYKSSSPLPAVNL 1169 spotted green...
CAG01546      899 -------------vS--DSPRI------------------HLPLTYSPG------------SPDIGRHYRSNSPLPSIQL 933  spotted green...
XP_006631963  909 --------vT-------DSPRI------------------HLPLNYPPG------------SPDLGRHYRSNSPLPSIQL 943  spotted gar
XP_007507570  979 pr---tddaENE--Ee-VTTSIdvavdieea-tmekynwgTNSSTFKPD------------GPDLAQHYKATSPQPAFHI 1039 gray short-ta...
XP_012408812  888 sg---neelENE--EeeVSTSLdvvidieed-tmakynwgTHSSTFKPD------------GPDLAQHYKATSPQPTFHI 949  Tasmanian devil
XP_700763     915 --------vN-------DSPRI------------------HLPLNYPPG------------SPDLGRHYRSNSPLPSIQL 949  zebrafish
ACF95733      430 sk---pddaVHE--P--INGTIslpaeleeqsigrfdwgpAPPTTFKPN------------SPDLAKHYKSASPQPAFHL 490  domestic ferret
XP_003970301  896 sk---pddpTHE--H--VNGTLdlpveleeq-tmgkynwaTTPTTFKPD------------SPDLAKHYKSASPQPTFQI 955  torafugu
EHB13576      859 tk---tddaNNG--G--NGVTLdlpieleek-hmgkynwgTTPTTFKPD------------SPDLAQHYKSASPQPAFQI 918  naked mole-rat
XP_012906122  730 ------eikaddvdndgnSVTLglpieleeq-tmgknnwgTIPTTFKPD------------SPDLARHYKSASPQPAFQI 790  domestic ferret

CAG11168     1170 QPHSPPAegKKHQAVQDLPPSNTFVgsggcvgsagssssssggsG-NGDAMSVGSDQCSE-YGCHTGN 1235 spotted green pufferfish
CAG01546      934 QAQSPSAs-QKHQVVQDLPAANTFV-------------------GtGGDDNSTGSDQYSD-YSYKTSQ 980  spotted green pufferfish
XP_006631963  944 QPQSPSAs-KKHQAVQDLPATNTFV-------------------G-TGDNNSTGSDQYSD-YSYKANP 989  spotted gar
XP_007507570 1040 EPETPVH--SKHHVIQELPLDNTFV-------------------M-GCDslskcsssssdpysisdcs 1085 gray short-tailed opossum
XP_012408812  950 EPETPMH--SKHHGIQVLPVDNTFV-------------------L-GCDSLSKCSSSGSDpYSISDCS 995  Tasmanian devil
XP_700763     950 QPQSPSAs-KKHQAVQDLPATNTFV-------------------G-TGDNNSTGSDQYSD-YSYKANS 995  zebrafish
ACF95733      491 KPDTPVSv-KKHHVIQELPLDNTFV-------------------G-GCDTLSKRSSTSSDhFSASECS 537  domestic ferret
XP_003970301  956 KPETPVAp-KKHHVIQELPLDNTFV-------------------V-GCDSLSKCSSTSSDpYSVSECG 1002 torafugu
EHB13576      919 QPETPLN--SKHHIIQELPLDNTFM---------------------ACDSISKCSSSSSDpYSVSECS 963  naked mole-rat
XP_012906122  791 YAETPLN--SKHHVIQELPLDNTFV---------------------TCNSISKCSSSSSEpYSVSECS 835  domestic ferret
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