3VKG,4RH7


Conserved Protein Domain Family
DHC_N2
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pfam08393: DHC_N2 (this model, PSSM-Id:285579 is obsolete and has been replaced by 462462)
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Dynein heavy chain, N-terminal region 2
Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Links
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Statistics
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PSSM-Id: 285579
Aligned: 693 rows
Threshold Bit Score: 83.0329
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3VKG_A         29 EEIQDLKAVWVELSNTWQeiDSLKETAWSAIIPRKVRKSL---EDT-LQklknlpnrir--------------qysafdh 90  
Q57VL9        751 rvFDVLEQFWCSVFDSTRv-KDYYIIPLSALNSEKTIDEVqrcRRLlHSsvrnlrgy------------------pglvc 811  Trypanosoma b...
XP_003110956  635 GEIESLQSLFVATSGYYKhvNAFFESRRTLVNIDASRNFI---EQFtVQlsvfesslathr-----------aakhfiay 700  Caenorhabditi...
CAP35738      615 GEIESLESLFVATSGYYKhvNAFFESRRTLVNIDASRNFI---EQFtIQlsifessltthr-----------aakhfiay 680  Caenorhabditi...
XP_009040135  808 CALSSLEQLWRAAESWRSqtTIWMEARCGDLDPAVLEDVLvthSSAfRTslhnlsgn------------------eaavs 869  Aureococcus a...
EKF99314      750 RTFEVLEQFWGAIFDSTTv-RDYYNIPISKLNATQMVDHVqrcRRLlHFstrslray------------------pglvr 810  Trypanosoma c...
XP_001581021  840 SDFDMLLPAWSIAVEIDTtaQDWFGTIFKQLDVQMISDTVvewENTlKKlmedieaaknqdrhkkflregvhpleapyke 919  Trichomonas v...
XP_004988387 1656 EQIDLLTDCWQRMREWDArfEQWMPLPLAQLDLEEMNAFV---SSFlNAlthaqhtlsttfak-------iatytnkaad 1725 Salpingoeca r...
XP_001747718  806 TRLQLLKTCYSLFHESEAarQALVKHDIASLQIDAATAQLdgmEQTwGSchvqlsda------------------pvlqh 867  Monosiga brev...
XP_001318628  702 RLSNCLMKLWVSTKEYSMenEKIAGTQIGLIDTEEISKKF---EKWvGSindacdglk---------------efqiprn 763  Trichomonas v...

3VKG_A         91 aqNLIK----IY-LKGNAIITDL-HSEAIKD--------------RHWKILKK--------RL----------------- 125 
Q57VL9        812 lgRQQEqvlaDF-ESLQTLLAYL-STPGLRK--------------NHWKEIGR--------ILqlg-------------- 853  Trypanosoma b...
XP_003110956  701 arneVD----TF-KKNFSVAEVMsCRRLL-D--------------AHWLRMSE--------IVg---------------- 736  Caenorhabditi...
CAP35738      681 arneVD----SF-KKNFSVAEVMsCRRLL-D--------------AHWLRMSE--------IVg---------------- 716  Caenorhabditi...
XP_009040135  870 yhGMAE----DF-RLVIGLIREL-RSPFLRN--------------RHREAVED--------ILgfsisaipqrdgaggdl 921  Aureococcus a...
EKF99314      811 lgRQQEqvlnDF-ECLEGILICV-TAPGLRK--------------NHWKEISR--------ILgkd-------------- 852  Trypanosoma c...
XP_001581021  920 lqARV-----QYiLMHIPIIRYI-CNPNYRQ--------------RHWKQISE--------TAg---------------- 955  Trichomonas v...
XP_004988387 1726 asllLD-------------ISEMvRSPWFGQ--------------RYVRRTSV--------LV----------------- 1753 Salpingoeca r...
XP_001747718  868 vaKNL-----HFaHQWLQVVELC-QTPEL-EeeeldsirdvlaipKRWEDILVadliqagaLA----------------- 923  Monosiga brev...
XP_001318628  764 iaILVEsnvkEF-KSYIPIINAL-SSIYLRN--------------RHWTMIND--------LFk---------------- 803  Trichomonas v...

3VKG_A        126 --------NTNWIITELTLGSIWD-S---DLar-----------------nENIYREVITAAQG---EIALEE-FLKGVR 172 
Q57VL9        854 ------rkQSTQIDSNVTLKQLLE-N---GIid-----------------hLDEIKLIVDPAFL---DFEAEA-TLERMK 902  Trypanosoma b...
XP_003110956  737 --------FDLTPYANSSIAQICE-L---GLea-----------------hLQQLKPIAFSAER---EATAAD-QLHSIV 783  Caenorhabditi...
CAP35738      717 --------FDLTPYANSSIAQICE-L---GLea-----------------hLQQLKPIAFSAER---EATAAD-QLHAIV 763  Caenorhabditi...
XP_009040135  922 aeappgltKLDAARLSVTLGQLIErHaikAL---------------------PAIKAITTRATH---EAILYQ-SLDEVR 976  Aureococcus a...
EKF99314      853 ------pnTNLQIDSNVTLQKLLE-S---RIqd-----------------hFYELKQLVDPAIV---DFETEA-SLERMK 901  Trypanosoma c...
XP_001581021  956 --------FQIGPNDDYTWNWLIE-F---GVeq-----------------hIIAIASISKAATN---EAKIEI-AIAQMC 1002 Trichomonas v...
XP_004988387 1754 -----------------------------VLnidvnittygylhaskppqrVEALEDLFVQAEE---EQRREQ-QWKELN 1800 Salpingoeca r...
XP_001747718  924 --------------KKPSVVKLVEkArarHLf-------------------VAHVAAIAEWLRTelvETEIRGsALHGMR 970  Monosiga brev...
XP_001318628  804 --------LDHPLDQSATLYYLID-I---IVln-----------------kEKEIMDIVKIAEN---EYILED-FLDGII 850  Trichomonas v...

3VKG_A        173 E---FWTTLELDLVNyqr-----kcKLVr--gWDDLFNK--LAEHLNSISAMKMSPYYKV---FEEE-ANHWDDRLNKVR 236 
Q57VL9        903 S---DAKKTRFVFEVaegs---ndaLILsprcRTSISSQ--LEAFSHELSALRQVEHLSQ---YTISsVMEFDSVVQRMK 971  Trypanosoma b...
XP_003110956  784 T---FWSQEHLEMRFhv------qwKLSlavkLRDLHSR--VQTDINTLKHMTNV---EQ---ITDDsLPQWIEWTCRTE 846  Caenorhabditi...
CAP35738      764 T---FWSQEHLEMRFhs------qwKLSlavkLRDLYRR--VQNDINTLKHMTNV---EQ---ITDDsLPQWTEWTARAE 826  Caenorhabditi...
XP_009040135  977 T---TWAGAEFVVLNyngrkd-----aptlacIQVLVDD--VQKDMAALVQLLESPHVSY---IREE-LEGWHASLVKLA 1042 Aureococcus a...
EKF99314      902 S---EAKRTRFIFEIiegt---eevFALsplcRDSISSQ--LETFLLDLRALREHFSVSH---YVINsINEWEAAVEKMR 970  Trypanosoma c...
XP_001581021 1003 D---DLQKLRFKVTKte------hgIHL----DDPATALllLAKHQQIMQEIFVPPYIQP---FISK-VKEYELLAANTR 1065 Trichomonas v...
XP_004988387 1801 E---KWDSMVLPIKRqgstllgrdaYLLe--nVSALRDE--IVHAEMVLLNLSRS---DAspeLKSK-ARALHEKITTFE 1869 Salpingoeca r...
XP_001747718  971 T---------LAVAN-----------------LGSLLRQ--TVNRRADLRQLLKSSYR-----TVQSgITELSRRTNRTF 1017 Monosiga brev...
XP_001318628  851 AsfyDWT---FSITLfnc-----------snfIKEGISR--LQDQMRDLRKVKKSNFKNL---FLQK-IEKHENFVTQMQ 910  Trichomonas v...

3VKG_A        237 SLLDVWIDVQRRWVYLEGIFSgSg-----DINQlLP------AEST---R-FKSINSEFIail----------------- 284 
Q57VL9        972 ETLLTWEDVEKEWKEVLPFG---------ITLE-TT------TDED-----FIGLTPRdlkllrekvsst-sdtfkslaa 1029 Trypanosoma b...
XP_003110956  847 TILKAWCETQQKWMRVANIFV-Tc----rDTLQ-VS------FDSNiqqDlYYLLQKEYEllrtcaky-------fikie 907  Caenorhabditi...
CAP35738      827 TILKAWCETQQKWMRVANIFV-Tc----rDTLQ-VK-------------NlFNVTQKSEElftegiritenlcqifpnhr 887  Caenorhabditi...
XP_009040135 1043 MQLDALTEIQSGLTRLTFQFR-VpesssvSRVT-SFdlgsliPVAE---RvLNDTEPWWRdlm----------------- 1100 Aureococcus a...
EKF99314      971 CTLSNWNEIEYEWIEVMYFG---------MTLE-AI------SDGE-----IPAVESRewkflrekvgsi-ngifsilya 1028 Trypanosoma c...
XP_001581021 1066 QILKQSIETEERINELQPAME-St----dLKTQ-HSkmtnffEDKV---KdFSNFATNFKlsa----------------- 1119 Trichomonas v...
XP_004988387 1870 QRLSQWEDCERAWSRVHAPMT-Agln-------------nnsEEFAhavTiYKSTMRQWRalc----------------- 1918 Salpingoeca r...
XP_001747718 1018 EILTDLQSLQDNWMALQSL------------RS-LF------KRHQsvaKaFEHFKCQWVpva----------------- 1061 Monosiga brev...
XP_001318628  911 DFVTLLRKIYNLYLYQNDFME-Aedt--------------isHQYSfylT-FGDIKSNLTdl------------------ 956  Trichomonas v...

3VKG_A        285 kkvSG-----AP---LilevlaieriqQ-TMERLSDLLGKVQKALGEYLERQRSAFARFYF-VGDEDLLEIIGN-SKDi- 352 
Q57VL9       1030 tlrKAqytlfTAmmqEn---------iQdQVTLARTILGDVRKILASSLDAKREVFPRFYL-MDDESLLSFLSVhNAT-- 1097 Trypanosoma b...
XP_003110956  908 rnvVKdatiyRVmqlPh---------lPcWIEKIRKMVVVIIQGVRGLLDGMRMINSRLCL-SSELHLLNLF---STT-- 972  Caenorhabditi...
CAP35738      888 eerSKrcdhlSSdatTp-----------fALLDRENPFN-----VRGLLDGMRMINARLCL-SSELSLLNLF---STT-- 945  Caenorhabditi...
XP_009040135 1101 tsiSSepsvlRAallPamk--------qqELEKHRSGLHMAMNEIRSHLQSRREAFPRLYL-CADDALLPSIAQtSLGna 1171 Aureococcus a...
EKF99314     1029 glqKTqytlfTAmiqEn---------iQeQLTLASTILGDIRKVVMGLLDAKREAFPRFYF-LSDRELISFLSVvNNT-- 1096 Trypanosoma c...
XP_001581021 1120 -tfHMilsnqST---------------AdECNSIAQDLVKVRDQLQDVLEMKRKAFPRFRL-LSDSQLIQVISN-GETp- 1180 Trichomonas v...
XP_004988387 1919 qlgYRsehvlRDlcsPe---------vGqRLAEYHHQFQECYSLLIATVDAYSVTCTRLYM-LTPPEVLQLVGQ-ARSl- 1986 Salpingoeca r...
XP_001747718 1062 -qtIEkspvlGQlsdAm---------vReQLTACRTAWHTLQERISDAVGQLRSVAP-VLFaLPKGTIAASVGLpAVDqa 1130 Monosiga brev...
XP_001318628  957 ---------lsKctcCvlsi----smtE-KLEVIYDKIRELKEKIYPYLQNRRKEYYRLQY-LANSELFNYISS-TKNp- 1019 Trichomonas v...

3VKG_A        353 iKIq-KHF----R-KmfaGLANLTLDDEkt-----tII-GMSSA-EGETVTFKkpisiangpkIH--------EWLTMVE 411 
Q57VL9       1098 -KLk-RHL----T-TlysRVCDVNLEGNv-------VT-SFITT-DGSVLRtdtpie-lsplpVE--------QWMKTFD 1152 Trypanosoma b...
XP_003110956  973 -SId-TRLqlllK-DcfpSLRRLCFNRR--------NQlELVDL-LGEKVTVDltk-----teIEsqe---pcELIRSIE 1032 Caenorhabditi...
CAP35738      946 -TId-SRLklllK-DcfpSLRRLCFNRR--------NQlELVDL-LGEKITVDltk-----aeIEnqe---pcELIRSIE 1005 Caenorhabditi...
XP_009040135 1172 aALasPII----R-ScfpAVSTFELGIGskiskdilIT-----SpDGGHISIL----------FDfkmrcaleEWLHALN 1231 Aureococcus a...
EKF99314     1097 -KLk-QLL----S-KmysRVCDVGVEGNs-------VT-TFIAA-DGATLKaevpiq-lsavpVD--------RWMNSFE 1151 Trypanosoma c...
XP_001581021 1181 sKIp-TIF----S-LmypSIASAVFESNt-------YClGFNSQ-GGEYFEFIqkvri-tpecIE--------GWFIAFD 1237 Trichomonas v...
XP_004988387 1987 hSIk-PLI----C-KcfsDVSDLLLAEGr------kID-GLLAP-SGETIRFA----------QSivatgpthLWLPQLF 2042 Salpingoeca r...
XP_001747718 1131 hAL---------LpQlwtAVRHLVVADRd-------LS-GLCCH-SGEIFHLR----------QPfrlrgglaEWLPAVQ 1182 Monosiga brev...
XP_001318628 1020 eRFs-EQV----K-SlfpSLDGMIIENNk-------II-GVIGK-NSEQLRLNpiey--dikdVP--------LLLKTIE 1074 Trichomonas v...

3VKG_A        412 SEMKSTLATLLSESL 426 
Q57VL9       1153 RTLRSSLLNEIKMSV 1167 Trypanosoma brucei
XP_003110956 1033 TAFASKLTDIItyer 1047 Caenorhabditis remanei
CAP35738     1006 TAFASKLTDIItyer 1020 Caenorhabditis briggsae
XP_009040135 1232 LAMHRAVAKGLKPCL 1246 Aureococcus anophagefferens
EKF99314     1152 RTLRSSLLNELRACV 1166 Trypanosoma cruzi
XP_001581021 1238 QQITNTLKTLGRKII 1252 Trichomonas vaginalis G3
XP_004988387 2043 SEMQDFVKFDIlsah 2057 Salpingoeca rosetta
XP_001747718 1183 HEVATSLHEQRLAaw 1197 Monosiga brevicollis MX1
XP_001318628 1075 MKIEEKLTKTVidia 1089 Trichomonas vaginalis G3
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