Conserved Protein Domain Family

pfam08515: TGF_beta_GS (this model, PSSM-Id:285687 is obsolete and has been replaced by 400699)
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Transforming growth factor beta type I GS-motif
This motif is found in the transforming growth factor beta (TGF-beta) type I which regulates cell growth and differentiation. The name of the GS motif comes from its highly conserved GSGSGLP signature in the cytoplasmic juxtamembrane region immediately preceding the protein's kinase domain. Point mutations in the GS motif modify the signaling ability of the type I receptor.
PSSM-Id: 285687
View PSSM: pfam08515
Aligned: 26 rows
Threshold Bit Score: 33.6165
Threshold Setting Gi: 118404660
Created: 26-Jun-2015
Updated: 5-Aug-2015
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
3H9R_A        10 TLADLLDhs---ctSGSGSGLPFLVQRTVAR 37  human
Q659I3       133 YFPEFTD-------SGSGSGKPFLVSQTIAR 156 Echinococcus multilocularis
XP_002412676 179 TIKDMMem----ttSGSGSGLPLLVQRSIAR 205 black-legged tick
XP_002033009 291 TIHDIIEmt----tSRFGFGLPLLVQRSIAR 317 Drosophila sechellia
EFX86076     191 TIKDMVDhs---qsSGSGSGLPLLVQRTIAK 218 common water flea
GAA27846     260 TLRELLEet----cSGSGSGVALLVQRTVAR 286 Clonorchis sinensis
XP_003426889 199 TLKEYLEgqs--ltSGSGSGLPLLVQRTLAK 227 jewel wasp
EHJ73578     240 TLRQYLEgs---atSGSGSGQPLMVQRTLAK 267 monarch butterfly
EFX65169     244 TLREVFEhs---vtSGSGSGMPLLIQRTLAK 271 common water flea
Q4H2Q1       171 GHNEMMEnwsslagTSSGSGMPLLVQRTISR 201 vase tunicate
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