Conserved Protein Domain Family
rRNA_processing
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pfam08524: rRNA_processing (this model, PSSM-Id:285696 is obsolete and has been replaced by 400708)
rRNA processing
This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.
Links
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Statistics
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PSSM-Id: 285696
Aligned: 29 rows
Threshold Bit Score: 58.8113
Created: 25-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6CRY6         4 VEKKKFT--KE--Y--RLKEIQRNLTKKARLKKEYLKVLKDEGYSIP-----EK-------PQYEKHDRSSVEAKKALNK 65  Kluyveromyces l...
XP_012061822  28 FDKKKYRl-QK--YsnKYKINQWEERRKKAVLREYYKELKKDQQNSA-----GTss---nlS---NTSKNTNETSKLKKN 93  Atta cephalotes
EFZ15182      28 FDKKKYRl-QK--YsnKYKVNQWEERRKKAVLREFYKDLTKEQQNSL-----GTsl---ntSENADEASS----KLNKKG 92  red fire ant
XP_001607665  28 FNKKKYRe-QK--YsnKFKVNQWEEKRKKAILKGFYKDLKKEEKAAN-----FKfs---rkSNSENPEDDNSESSSKKAK 96  jewel wasp
EFN84662      28 FDKKKYRl-KK--YsnKYKINQWEERRKKTVLRDFHKELKRDQQNST-----QAsi---nsN---NTSKDAQETSNSKKA 93  Jerdon's jumpin...
EFX88179      16 FNKKKWRe-TQ--YshKERVSEWESKRKEAVKRKYRKMLKKDESTSS-----VQttyqlynAEEGNVNGYSEPPRQRL-- 85  common water flea
XP_004195044  11 ntrfsykdrHE--L--KSKEIKKSLTHRATLRRKYFKMLENEGLSSNageakEReg---asGDHESEEASLSEKPEHGES 83  Pichia farinosa...
XP_011253596  23 fdkkkYRl-QK--YsnKYKINQWEERRKKAVLREYYKELKRDQQTSS-----QIss---ncASKNTNEMSNSKSK----S 87  Florida carpent...
NP_001155540  12 fdkkkWRt-KK--YsnKQKFQDWDERRKKAVIRDYYKELNKSGNERP-----LDtl----nDEDNNLTKQQKRPN----- 74  pea aphid
EPY52986      10 KEGFKFRvlPEhaYqgKAKKIKQDLILKAKAKKHYYKTVKPEEYGKK---------------------RTEEEAPKP--- 65  Schizosaccharom...

Q6CRY6        66 QKVRDQR--------------EEHKLRKRTQKEKEQSFKEQEMKRIqlsKEKQVERDRRAKKLTQRTKRGQPVMGPKIND 131 Kluyveromyces l...
XP_012061822  94 SAFFKAK--------------REYRRKQEEKKNRLENAIRVKTEREealKKYREKKLQNYKVLSKKTKKGQPVMKGRIEM 159 Atta cephalotes
EFZ15182      93 YAFFKAK--------------REYKRKHEEKMKRKEEAIRKKVEREealKKYKEKKMRNFKLLSKKTKKGQPVMKGRIEL 158 red fire ant
XP_001607665  97 IPFFSAK--------------QEYLKKKQEKDRKKEELLKAQEERKkalEKYKEKKMQTYKQLSKKTKKGQPVMKGRMEL 162 jewel wasp
EFN84662      94 YAFHKAK--------------QKYQETKKEKERKKQETVRIKSEREealKRYKEKKMQTFKVLSKKTKKGQPIMKGRIEM 159 Jerdon's jumpin...
EFX88179      86 SEFQRAK--------------LEYERIQGLKEEARLEREQKIKEREiaiMKSKQMRLERIKKLTQKTKKGQPVMKGRIEI 151 common water flea
XP_004195044  84 REHEAREktnvkqtkkalpyiERAKKVKELKEKRRQEKLKQIRDQLkasESKTLQRQKEKEILSQKTKRGQPLMGPRINN 163 Pichia farinosa...
XP_011253596  88 YAFYKAK--------------QEYKRKQEEKKKRIQDMIRVKAEREealKKYKEKKLHNFKMLSKKTKKGQPVMRGRIEM 153 Florida carpent...
NP_001155540  75 -PHKEAQ--------------ERYNQIQEEKKARRFEASKKKEEIRqalEEYKQKKKLKNKKLGKKTRKGQPVMKERLEL 139 pea aphid
EPY52986      66 TPRKNHL--------------EQLYEVSEDKRRRKEEAIKKKQEKQqehDRKIHERIETRKQLSKRTKHGQPVMKNQVSV 131 Schizosaccharom...

Q6CRY6       132 LLDKINSD 139 Kluyveromyces lactis NRRL Y-1140
XP_012061822 160 LLEKIQQi 167 Atta cephalotes
EFZ15182     159 LLEKIQRS 166 red fire ant
XP_001607665 163 LLEKIQQS 170 jewel wasp
EFN84662     160 LLEKIQQS 167 Jerdon's jumping ant
EFX88179     152 LLQKIQKQ 159 common water flea
XP_004195044 164 LLDKIRKD 171 Pichia farinosa CBS 7064
XP_011253596 154 LLEKIQQS 161 Florida carpenter ant
NP_001155540 140 LLEKIQAS 147 pea aphid
EPY52986     132 LLGKVKKE 139 Schizosaccharomyces cryophilus OY26
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