Conserved Protein Domain Family
ASD2
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pfam08687: ASD2 (this model, PSSM-Id:285850 is obsolete and has been replaced by 462561)
Apx/Shroom domain ASD2
This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.
Links
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Statistics
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PSSM-Id: 285850
Aligned: 61 rows
Threshold Bit Score: 250.951
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008208250 1557 DLANQLGPDDK-LLPILVPIPEHKKSTDYVVDLFR-VEAALHPRPRPRltineestsidaadnES----EEDKKIDSIPS 1630 jewel wasp
NP_001095764  535 ELVQELARLDPsQSDTFTSYPSPEPALGLLDGLIPlAEVWAAMRPACR---------------EA----GEEAAGNSEPG 595  cattle
XP_005335822  547 ELVQELARLDPsLSDTLTSQPCPEPPLGLLDGLIPlAEVWAAMKPGCG---------------EA----GEEGPGTSEPG 607  thirteen-line...
XP_012664674  459 ELVQELARLNPsLSDTLAFQPSPEPPLGLLDGLIPlADVWAAMRPACG---------------EA----GEEAAGTSQPG 519  small-eared g...
XP_004745125  563 ELVQELARLDPsLGDTLTSCPSPEPPLDLLDGLIPlAEVWAAMRPLCG---------------EA----GKKAGGSPEPG 623  domestic ferret
XP_010588279  550 ELVQELARLDPsLSDILAPHPSPEPPLDVLDGLIPlAEVWAAMRPACG---------------EA----GEEAGGTSEPQ 610  African savan...
XP_009447907  544 ELVQELARLDPsLCDPLASQPSPEPPLGLLDGLIPlAEVRAAMWPACG---------------EA----GEEAASTFEPG 604  chimpanzee
XP_008253221  575 ELVQELARLDPsLSDTLAAQPSAEPPLGLLDGLIPsAEVWAAMSA------------------------AEDAAGTSESG 630  rabbit
EHB00064      345 ELVQELARLDPsLSDTLASEPSPEPPPGLLDGLIPlTEAQATVWPAFR---------------EP----GEEVASTSEPG 405  naked mole-rat
XP_007668469    1 -----------------------------MEGLFP-ESFTTLGRGDRK---------------RRarlgEEVPSTAGGEQ 35   platypus

XP_008208250 1631 TPVTpsapdssssssssplsassvYFTTSESKARFLT--RYSQDVVAEQVTTTPAT-P-SikpttPDslDLRQKKEELMI 1706 jewel wasp
NP_001095764  596 SYLL--------------------NSTQHLPTSQEET--RPENLTTHVAPDQPCDQdV-P-----KPnnSIQAKKAELAD 647  cattle
XP_005335822  608 SYQF--------------------NFTQLLPTSQEMT--RPENSPSCPMPDCPNAQ---------TSnnSVQAKKVELAG 656  thirteen-line...
XP_012664674  520 SYQF--------------------SFTQFPPTSQEEE--ILKNSATHPVPDQPHGQ-GfP-----EPnnSIQAKKVELAS 571  small-eared g...
XP_004745125  624 FYLF--------------------SSSQLLSTSLEET--RFENHTTHPVPDQACGQgL-P-----QPnsSIQAKKMELAD 675  domestic ferret
XP_010588279  611 SCLP--------------------SSAQLLTTSQDET--RAENFTMCPVPEQPYGQ-G-Pp----EPtnSIQAKKAELAD 662  African savan...
XP_009447907  605 SYQF--------------------SFTQLLPAPQEET--RLENPATHPVLDQPCGQgL-P-----APnnSIQGKKVELAA 656  chimpanzee
XP_008253221  631 SNQL--------------------SSPQLLPTSQE-T--RPEDPGAHPVPDQLCGRgL-P-----APhsSLQARKVELAD 681  rabbit
EHB00064      406 SCLF--------------------SFTQLLPASQE-T--RPENATLLPVPNQPCGQgL-P-----AQnvSIQVKKVELAG 456  naked mole-rat
XP_007668469   36 SPDS--------------------PVTVMVADAEQDPapEADPAPSDPQRVQLPSKgA-A-----ADpdGITAKKAELAG 89   platypus

XP_008208250 1707 RLDKKLVVLRAEQEAVREEGEVNEALGSRVQARIAALAKPAEASKYRLHVEEVGKITSLLLGLSGRLA------------ 1774 jewel wasp
NP_001095764  648 LLQKMLRDLQAEQKQLQGAAQAWARRGAALEAAVGQACAPHELERFSRFMADLERVLGLLLLLGSRLA------------ 715  cattle
XP_005335822  657 LLQEMLQDLHIQEERLQDAAQEWTRRRLALESAVGQACAPRELERFSRFLADLERVLGLLLLLGSRLA------------ 724  thirteen-line...
XP_012664674  572 LLQKMLWGLHSEQERLQEAAQTLARSQAALEVVVNQACEPRELERFSRFMADLERVLGLLLLLGSRLA------------ 639  small-eared g...
XP_004745125  676 LLQKMLRNLEAEQEQLHGAAQAWARRGAALEAVVGQSCSPRDLERFNRFMADLERVLGLLLLLGSRLA------------ 743  domestic ferret
XP_010588279  663 LLQKMLRDLQAEQERLRGAAQACARRRAALESAMGQACAPQELERFSRFMADLERVLGLLLLLGSRLA------------ 730  African savan...
XP_009447907  657 RLQKMLQDLHTEQERLQGEAQAWARRQAALEAAVRQACAPQELERFSRFMADLERVLGLLLLLGSRLA------------ 724  chimpanzee
XP_008253221  682 ILQKMLGELHAEQERLHLRAHKWASGQAALEAAVGQACAPRELERFRRF-----------------LAdlervlglllll 744  rabbit
EHB00064      457 LLQKMLQDLHARQEQLQGVAQAWARRRAALEAAVAQACAPRELERVSRFMADLERVLGLLLLLGSRLA------------ 524  naked mole-rat
XP_007668469   90 LLRDKLHGLREERRSVLAAAKACARWGTELDELVRHTCKPNEHERYAQFIGDLEKVVSLLLCLSSRLA------------ 157  platypus

XP_008208250 1775 -----RAENALYGMPADHP--ERKILESKRDKLMDQLEEAKILKGNIDRRSVNVSAILSKYLSDEEFADYQHFINMKAKL 1847 jewel wasp
NP_001095764  716 -----RVHRALARVGADSDpeEQASLLQRLGLLQRQEKDAKELKQHVARRERALRELLARALPAEELSAYRTLLAGKAAV 790  cattle
XP_005335822  725 -----RVHHALARMGSDGDpdERDSLLQRLGLLQRQQEDAKELKEHVARRERALREVLARALSAEELCSYSELLVGKATL 799  thirteen-line...
XP_012664674  640 -----RVRRALAWAGADGDpdERASLLRRLELLQRQQEDAKELKEHVARRERALREVLARALPVEELRAYSALLAGKAAV 714  small-eared g...
XP_004745125  744 -----RVRRALARDGVDCDpdEQASLLQRLGLLQRQQEDAKELKEHVARRERALREVLVRALPTEELSAYRALLAGKAAV 818  domestic ferret
XP_010588279  731 -----RVRCALVRAGSNGDpdERASLLQRLRLLQQQQEDAKELKEHVARRERVLREVLMRTLPVEELHAYCALLAGKAAV 805  African savan...
XP_009447907  725 -----RVRRALARAASDSDpdEQASLLQRLRLLQRQEEDAKELKEHVARRERAVREVLVRALPVEELRVYCALLAGKAAV 799  chimpanzee
XP_008253221  745 gsrlvRVRRALARAGSDGDpdEHASVLQRFRLLQRQQEDARELKEHVARRERALREALERALPAEQLRSYCALLAGKAAI 824  rabbit
EHB00064      525 -----RVHRALARVGSDGDpeERASLLQRLGLLRRQQEDARELKEHVSRRERALREVLARALPAEEVRAYCTLLADKAAV 599  naked mole-rat
XP_007668469  158 -----RVQNALARVDESTDaeERQSLNDRLSLLSRQREDAKDLKENLDRRERVVCGILSKQLPPAQLQDYRDFVRTKASL 232  platypus

XP_008208250 1848 IVDGREIQDKVKLGEEQLAALKEA 1871 jewel wasp
NP_001095764  791 LAQQRSLDERVRLIQDQLDAVRND 814  cattle
XP_005335822  800 LTQQRCLEEHVRLFQNQLDTLGSN 823  thirteen-lined ground squirrel
XP_012664674  715 LAQQRSLDERVRFLQDQLDVVSSD 738  small-eared galago
XP_004745125  819 LAQQRSLDERARLLQDQLDAIRSD 842  domestic ferret
XP_010588279  806 LAQQRSLDERVRLLQDQLDAVKSD 829  African savanna elephant
XP_009447907  800 LAQQRNLDERIRLLQDQLDAIRDD 823  chimpanzee
XP_008253221  825 LAQQRSLDERVRFLQDQLDAIgrd 848  rabbit
EHB00064      600 LAQQRSLDERVRLLQDQLDAVRSD 623  naked mole-rat
XP_007668469  233 LMEQKGLDERIMFCEEQLESLQSS 256  platypus
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