Conserved Protein Domain Family
Preseq_ALAS
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pfam09029: Preseq_ALAS (this model, PSSM-Id:286162 is obsolete and has been replaced by 462658)
5-aminolevulinate synthase presequence
The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.
Links
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Statistics
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PSSM-Id: 286162
Aligned: 12 rows
Threshold Bit Score: 141.871
Created: 26-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6DF22         5 INRCPFATRDPTVFLRVARPF-LLRSAERCPVMV-----------T----CTL----STSPGCEQRTk--D--TTPVTGV 60  western clawed ...
NP_958444      4 IIRCPFLSRVPQTFLQQARKS-LVAYAVKCPVMMdl--------aS----RPLlrplCSSSASFQKV---E--DSSSAGH 65  zebrafish
XP_004780121   5 VRRCPFLSRVPQAFLQKAGKS-LLFYAQNCPKMMefga----kpaT----RAL----STSAVHCQQVk--E---TPPANE 66  domestic ferret
XP_005327047   5 VRRCPFLSRVPQAFLQKAGKS-LLFYAQNCPKMMevgs----kpvP----RAV----STSAVHCQQIk--E---TPPASE 66  thirteen-lined ...
XP_005797027   5 VRRCPFLACVPQAFFQQSRKS-MVTYAQRCPIMMelaskpmapsmA----RAL----CSSTSNQTTEi--KtgNVPVVGV 73  southern platyfish
XP_007248458   4 IIRCPFLSRVPQAFLQQARKS-LVSYAVKCPVMMdl--------aSrplvRAV----CSSSTSFQKSq--D--TVS-STE 65  Mexican tetra
XP_003210052   5 VRRCPFLARVSQAFLQKAGPS-LLLYAQHCPKMMeavp----paaA----RGL----ATTAVREQQA---E--ETPAARP 66  turkey
XP_005997366   5 LHHCPFLSLLPRACLHRARSS-LIHYAVCCPVMM-----------T----RGL----STTSADLHGMk--D--VTPVAAP 60  coelacanth
XP_002194991   5 VRRCPFLARVSQAFLQKAGPS-LLLYAQHCPRMMea--------aP----PAA----RALATSAARGqqaE--EESPAGR 65  zebra finch
XP_011600858  60 sqRCPFLSTVPSVYQKLSTKSaLVSYAHKCPVLMev--------vS----RAL----HDSAAAA---------KTSPANE 114 torafugu
CAF94336       5 LHHCPFLKSGPNPALRRSGTA-LLSMAHLCPII------------A----RQI----SVSSIAAPGEd--L--AISPAKP 59  spotted green p...
XP_003215788   5 LHRCPFFTRDPATVLHKLRPL-LVCSAQRCPVFM-----------T----HSF----SQSVANLQHGk--E--T---PGD 57  green anole

Q6DF22        61 STGASN-----------------RRTLAQA----------AP--------QAAISNAT-CPFIENEIGKSEGIIVQRAGP 104 western clawed ...
NP_958444     66 EASDAP-----------------AVPAGHP----------AP--------PAGHASASkCPFLAAEMSQKNSGVVRQASM 110 zebrafish
XP_004780121  67 KDKTAKaevqqaadgsqqtphgtQFPSGHP----------SL--------ATSQGTASkCPFLAAQMSQKGSSVFRKASL 128 domestic ferret
XP_005327047  67 KDKTAKakvqqapdrsqqtpngtQLPPGHH----------SP--------AMSQGTASkCPFLAAQMSQTGSNVFCKASL 128 thirteen-lined ...
XP_005797027  74 ESK---------------------LPTGHP----------VP--------TTGQAVASkCPFLAAEMKQKNSGVVRQVTM 114 southern platyfish
XP_007248458  66 EPKEAP-----------------KMPSAHP----------TV--------PAGQTSASkCPFLAAEMG-PNSSVVRQASL 109 Mexican tetra
XP_003210052  67 EAKNAK-----------------EVAQQNTdgsqppadhpPA--------AAGQSSATkCPFLAAQMNHKSSNVFCKASL 121 turkey
XP_005997366  61 TS----------------------LKIAHQ----------VPlnsrsvvqTASQPVVSkCPFAQPEIANGASKVVRKASP 108 coelacanth
XP_002194991  66 EAKNVKevaqq-------nadgaQLPAGHP----------PA--------SASQSTATkCPFLAAQMNHKKSNVFCKASL 120 zebra finch
XP_011600858 115 DPNHRI-----------------QLSPNEP----------TD--------AAGQAVTPrCPFLTAE----KNRVVSEASM 155 torafugu
CAF94336      60 TADQR-------------------RPLTQT----------SP--------QVDVSVAKgCPFVTSRIG------MVHASP 96  spotted green p...
XP_003215788  58 TASVL-------------------QPVPAS----------LP--------------TTqCPFIESERQSGRSPFVQVAKP 94  green anole

Q6DF22       105 QVQEDISAFK 114 western clawed frog
NP_958444    111 ALQEDVSEVR 120 zebrafish
XP_004780121 129 ELQEDVQEMH 138 domestic ferret
XP_005327047 129 ELQEDVQEMH 138 thirteen-lined ground squirrel
XP_005797027 115 EFQEDVEEVR 124 southern platyfish
XP_007248458 110 ELQEDVSEVR 119 Mexican tetra
XP_003210052 122 ELQEDVKEMQ 131 turkey
XP_005997366 109 EVQEDVQDGs 118 coelacanth
XP_002194991 121 ELQEDVQEVQ 130 zebra finch
XP_011600858 156 ELQEDVQEMD 165 torafugu
CAF94336      97 EVQEDIKKGl 106 spotted green pufferfish
XP_003215788  95 EVQEDVWpsk 104 green anole
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