1EG3


Conserved Protein Domain Family
EF-hand_3
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pfam09069: EF-hand_3 (this model, PSSM-Id:286195 is obsolete and has been replaced by 462669)
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EF-hand
Members of this family adopt a helix-loop-helix motif, as per other EF hand domains. However, since they do not contain the canonical pattern of calcium binding residues found in many EF hand domains, they do not bind calcium ions. The main function of this domain is the provision of specificity in beta-dystroglycan recognition, though in dystrophin it serves an additional role: stabilization of the WW domain (pfam00397), enhancing dystroglycan binding.
Links
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Statistics
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PSSM-Id: 286195
Aligned: 25 rows
Threshold Bit Score: 114.675
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1EG3_A       166 LEDKYRYLFKQV-------ASsTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGsnIEPSVRSCFQFAnNKPEIEAALFLD 238 human
A2CI97       122 LSAKQRALFRLAesysgnqESdRGSISRSALRVLLEDLSQVPAVVQENHVFGH--AETAVSSCFNGV-ISAGVTEEHFIW 198 zebrafish
Q1RL59       141 LVKKYKLLFSLY-------SGsLRMLTRSRCGLMLAHCVRLTDVVGEDINFGN--ISSAIASCFSGV-LGASISEQQLLQ 210 vase tunicate
Q9Y048       165 LVDKLRYIFSQI-------ADsNGLMDHIKFTDFLQQILSLTTAVFEAPTFGF--SENAVNQCFHK---DEKVSLNVFLD 232 Caenorhabditis ...
Q0E9B2       135 LVDKLRYIFSQI-------SDgAGQLVAWKLGEFLREVLALPAAVYESPTFHY--KEGLEEEIFPA---ENKVTVNDFMA 202 fruit fly
Q9Y4J8       144 IMDKLRYIFSMI-------SDsSGVMVYGRYDQFLREVLKLPTAVFEGPSFGY--TEQSARSCFSQ---QKKVTLNGFLD 211 human
Q8K0N0       144 MLDKLRYIFSQM-------SDsNGLMMFGKLDQFLKEALKLPTAVFEGPSFGY--TEHAVRTCFPQ---QKKIMLNMFLD 211 house mouse
AAH78203     133 LVDKLRYIFSQI-------SDsHGAMEMSKFDHFLREALKLPAAVFEGPSFGY--LDHLARSCFPQ---QKKVMLNMFLD 200 zebrafish
CAF87389      24 LVDKLRYVFSQV-------SDsNGVLVQSKFDAFLREALKLPTAVYEGPSFGY--AQASTRPCFPQ---QKRVTVNMFLD 91  spotted green p...
XP_009295876 150 ILDKLRYIFSQI-------SDpNGLMIYSQFDQFLREVLKVPVSVFEGPSFGY--TEQSTRSCFPQ---EKKVTLNVFLD 217 zebrafish

1EG3_A       239 WMRLE--PQSMVWLPVLHRVA 257 human
A2CI97       199 WLQSE--PRLLLWLSTLYRIS 217 zebrafish
Q1RL59       211 WLFKE--PQSLVWLPTMHRLN 229 vase tunicate
Q9Y048       233 TFLSDpcPPCIMWLPLLHRMA 253 Caenorhabditis elegans
Q0E9B2       203 TLMSEpgPSCLVWLPLVHRLA 223 fruit fly
Q9Y4J8       212 TLMSDppPQCLVWLPLLHRLA 232 human
Q8K0N0       212 TMMADppPQCLVWLPLMHRLA 232 house mouse
AAH78203     201 ALMSDppPQCLIWLPLVHRMg 221 zebrafish
CAF87389      92 ILEDP--PQCLVWLPLIHRLA 110 spotted green pufferfish
XP_009295876 218 TFMSDppPQCLVWLPLMHRLA 238 zebrafish
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