2XQ0


Conserved Protein Domain Family
Leuk-A4-hydro_C

?
pfam09127: Leuk-A4-hydro_C (this model, PSSM-Id:286244 is obsolete and has been replaced by 462686)
Click on image for an interactive view with Cn3D
Leukotriene A4 hydrolase, C-terminal
Members of this family adopt a structure consisting of two layers of parallel alpha-helices, five in the inner layer and four in the outer, arranged in an antiparallel manner, with perpendicular loops containing short helical segments on top. They are required for the formation of a deep cleft harbouring the catalytic Zn2+ site in Leukotriene A4 hydrolase.
Statistics
?
PSSM-Id: 286244
Aligned: 236 rows
Threshold Bit Score: 85.297
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2XQ0_A       473 NVYQLADKWvEMAQH-LkttedfrsefnAI--D-IKDFNSNQLVLFLETLTQ-NGhsnkkpkdfdwAKFPVASRALLDIY 547 baker's yeast
XP_002600370 498 PAEQLAAHW-AGDQM-Eens------dvVP--D-ISDWKTYQIVHFLDKLVE-RP-----------KLTHDTIQALAKKY 554 Florida lancelet
XP_006637904 472 PVKQLCELW-SVDPL-Dllt------iaTF--D-LSTWSTFQIVLFLDRLLD-RS-----------PLPHEVMSRLSRCY 528 spotted gar
EDL39984      96 PVEALFQLW-TAEPL-Eqaa------asASaiD-ISKWRTFQTALFLDRLLD-GS-----------PLPQEVVMSLSKCY 154 house mouse
NP_998856    475 PATELANLW-SSTPL-Dtet------isKV--D-PTIWRTYQLVYFLDRVLE-LS-----------PLPDGNVEQLEKYY 531 western clawed ...
XP_005996824 479 PVETLFKLW-TSETL-Dint------vsNI--D-ISKWKTFQMVLFLDKLLD-RS-----------PLPHEIMTRLCKSY 535 coelacanth
XP_004082881 518 PVQDLCDVW-RCADPpTpqt------lsAH--D-LSGWSTFQVVLFLDRMLD-QT-----------PLPRDVMASFSRSY 575 Japanese medaka
XP_008114481 374 PVETLFSLW-TTEPL-Davs------aaNS--VnITEWQTFQTVLFLDRLLD-GS-----------PLPHEVISKLSECY 431 green anole
XP_793744    513 PAEKLASYW-LTYHK-Ekdn------kdLSl-D-ISEWKTYQVLHFIDQLVEsEE-----------SLPHETLKHFATTY 571 purple sea urchin
CAG02141     528 PVEDLCEVW-RNGGG-Aeaa------aaASrfD-LSAWSTFQIVLFLDRMLD-LS-----------PLPLDVMSALSRCY 586 spotted green p...
2XQ0_A       548 --QdnIVKSQNAEVVFKMFKFQIFAKLQEEYKHLADWL--GTVGRMKFVRPGYRLLNSvd---rRLALATFDKFKDTYHP 620 baker's yeast
XP_002600370 555 p-K--IAESHNAELTMRWCMLIIKSNFTSDLPKVRAFL--ESQGKQKYTLPIYRALKAgspeaqDFAREVFEATKDTLHV 629 Florida lancelet
XP_006637904 529 --Sa-LLDGMNAEVRIRWLQIVVRNGFYPDLSQVRSFL--HTHTSRMYTVPLYEDLCSgv--mkSFAVEVFYQTQGRLHP 601 spotted gar
EDL39984     155 --Ss-LLDSMNAEIRIRWLQIVVRNDYYPDLHRVRRFL--ESQMSRMYTIPLYEDLCTga--lkSFALEVFYQTQGRLHP 227 house mouse
NP_998856    532 p-K--ISNATNAELRLRWAQIVLKNDYQLHFHKVRDFL--HCQGKQKYTLPLYRAMQAgskaaqDLARETFTQTCPQLHA 606 western clawed ...
XP_005996824 536 --Ss-LLDSMNTEIQIRWLQIIVRNSYYPDLYKVRRFL--ENQTSRMYTIPLYEDLCGgt--mkSFAIEVFYQTQNRLHV 608 coelacanth
XP_004082881 576 --Sp-LFDVLNAEVQIRWLQMVVRNTFYPELPRVRAFL--QKHTSRMYTVPLYEDLVTgv--mkCVAVEVFYQTQRRLHP 648 Japanese medaka
XP_008114481 432 saH--L-DSMNAEIRIRWLQIIVRNDYYPDLHKVRRFL--ENQMSRMYTIPLYEDLCTgt--lkSFALEVFYQTQNQLHP 504 green anole
XP_793744    572 p-Q--IRDTHNAEIRLRWSQLTIGSDYADDLSNVKAFL--IAQGKQKYTLPIYAALTKgskrmkDFAVETFAATKDQLHI 646 purple sea urchin
CAG02141     587 s-S--LFDGLNAEVQIRWLQMVVRNTFYPELPRVRAFQarKSHTSRMYTMPLYDDLVAgv--mkCVAVEVFNHTYRRLHP 661 spotted green p...
2XQ0_A       621 ICKALVKQD 629 baker's yeast
XP_002600370 630 NVRNYVQKI 638 Florida lancelet
XP_006637904 602 NLRRTLQQI 610 spotted gar
EDL39984     228 NLRRTIQQI 236 house mouse
NP_998856    607 NVQNYVKRI 615 western clawed frog
XP_005996824 609 NLRRTIQQI 617 coelacanth
XP_004082881 649 NLRRTLQQI 657 Japanese medaka
XP_008114481 505 NLRKTIQQI 513 green anole
XP_793744    647 NVRKHVEKM 655 purple sea urchin
CAG02141     662 NLRRTLQQM 670 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap