Conserved Protein Domain Family
Med12
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pfam09497: Med12 (this model, PSSM-Id:286572 is obsolete and has been replaced by 462818)
Transcription mediator complex subunit Med12
Med12 is a negative regulator of the Gli3-dependent sonic hedgehog signalling pathway via its interaction with Gli3 within the RNA polymerase II transcriptional Mediator. A complex is formed between Med12, Med13, CDK8 and CycC which is responsible for suppression of transcription. This subunit forms part of the Kinase section of Mediator.
Links
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Statistics
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PSSM-Id: 286572
Aligned: 86 rows
Threshold Bit Score: 65.607
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P25648        113 FQLPNRITLTDHRKETWLHELSSSHTSLVKIGKFIPHGLKRRQVIEQCYL-------KFIPLKRAIWLIK 175  Saccharomyces cerevisia...
AFW89878      152 gvyPEQRPCNEDARRKWIEALAQPNKRLRSLSEHVPHGYRRKSLFEGLIR-------YNVPLLRATWFIK 214  Zea mays
CBI40380      157 cvfPEQRPCGEDFRKKWIEGLSQHHKRLRSLADHVPHGFRKKNLFEVLIR-------NNVPLLRATWFIK 219  wine grape
XP_002972741  164 gQFPERHTYGEDYRKKWIEDLSQR-KRLSLLAEHVPHGFHRRTLFEALVK-------QNVPFLRATWFIK 225  Selaginella moellendorffii
XP_001754008   26 gvfPDHRTCGDDFRKKWIEDLSQR-KRLRALAEHVPHGYQRRTIFEALIK-------HDVPLLRATWFIK 87   Physcomitrella patens
XP_006662578  162 gmyPEQMHSNEDTRRKWIEALSQPNRRLLSLAEHIPRGFRRKSLFNYLIR-------YNVPLLRASWLVK 224  malo sina
XP_004367225  206 rHVPEQSAYSISLREAWVNKLKETNEPLQKLAAAVPHGYKSDQLIKMFLE-------FHIPVLRATWYTK 268  Dictyostelium fasciculatum
CDX74336      144 pgfPEQKSCGEETKKKWIESLSQQHKRLRSLADNIP-GYRRKTLFEVLIR-------NNVPLLRATWFIK 205  rape
XP_006682867  310 FTISRRTGTSSKTYDNWIDDLFG-NIPFSELSKSVPFGLKLDKLLESLQQ-------KQVSLVRATWAIK 371  Batrachochytrium dendro...
XP_001731396  115 WKPLAQPAVSETMLDMYSRDLANRDVPFATVARRLPRRISAEKILDLLWRapmgsspYSVPLPRAIWLIR 184  Malassezia globosa CBS ...
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