Conserved Protein Domain Family
Med4

?
pfam10018: Med4 (this model, PSSM-Id:287038 is obsolete and has been replaced by 401849)
Vitamin-D-receptor interacting Mediator subunit 4
Members of this family function as part of the Mediator (Med) complex, which links DNA-bound transcriptional regulators and the general transcription machinery, particularly the RNA polymerase II enzyme. They play a role in basal transcription by mediating activation or repression according to the specific complement of transcriptional regulators bound to the promoter.
Statistics
?
PSSM-Id: 287038
Aligned: 14 rows
Threshold Bit Score: 127.561
Created: 27-Jul-2016
Updated: 4-Aug-2016
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q2H2I4        30 QKLAEELLAAEAELSKSLKLLETHQNNNARLQQLRQETSLHDTQLKDIMSSLWNMRRELKAVP----------------- 92  Chaetomium glob...
Q0V090        30 PQAAIDLVAADDQLSHGLDQLSRHQANHARILTLRAQVEALEEQKKSSVTALATLRHELHATP----------------- 92  Parastagonospor...
Q7SA34        30 EKLAEDLVAADRELAAGLKELERHQNNHARILQLRQETASLDQQTKDIIGGLWNMRKEVKSTP----------------- 92  Neurospora crassa
Q54D00        69 LQLMNHLIDVDKIYQNTLKKLEKHQKIQKEITEIQKEIEEKDKLISTLALNLKDIESFLENELsqdn------------- 135 Dictyostelium d...
Q2M0F9        39 GDLLDLLVAKDEEFRKMLELAEEQAKVEDAMDKLRAKVEVHDREIQKLQKSLKDAELILSTAIfqar------------- 105 Drosophila pseu...
Q23523        47 TNIIKLFDSKQDSIKTLLKRVPEFQEREQLIRTLEAHVEKRDEVIQQLETNLKSCEVALTRSCfhan------------- 113 Caenorhabditis ...
Q6CJA3        62 LSLIDKVIECDKKLYETLEEFDEYYKIEEELSRLDKEQKNIDNKTREILETLNTCYNSLNELPmleqv------------ 129 Kluyveromyces l...
XP_001638176 216 AEVLEKLTSKDKELQAAVVQAKEQQKRQQDIESLKLHIAKKDEKILALEVQLKEAEQILSQAL----------------- 278 starlet sea ane...
XP_001392945  33 paaaIGLLDADDSLTSAVETLRQHQQNYAKILRLREEAQELEDKVKSIVREVMAYEKEIITTCgdesdsdldseddysdy 112 Aspergillus nig...
XP_001268437  33 paaalalldaNDSLTSAIDTLRQHQENYDRILRLRAEAESLEEKVKGVVREVVEYEKEIRAVCgdddmsdsdv--dddga 110 Aspergillus cla...
Q2H2I4        93 ----T---------------------TSNPPPGPKHQFTTSELLAYARRISRNTLPlpgvtngvdmtptqfsaslteped 147 Chaetomium glob...
Q0V090        93 ---------------------------ATSFPADTRPVRFDELLQYAKNISQYTVPptyrerapeaasdkdrdkddaas- 144 Parastagonospor...
Q7SA34        93 ----A---------------------TQYPATGPKYQFTTHELLNYAKRISRTTLPpahllynsepsesqqaggqggqpm 147 Neurospora crassa
Q54D00       136 -vniNngnasdgivnevlidlkqpddAASMDNIVNREVSPEDLISYAHKISGTTSA------------------------ 190 Dictyostelium d...
Q2M0F9       106 ------------------------qklASINQANKRPVSSEELIKYAHRISSANAV------------------------ 137 Drosophila pseu...
Q23523       114 ------------------------qklKQMKEAELRPVNSEMLIKLAHQISKHNSV------------------------ 145 Caenorhabditis ...
Q6CJA3       130 ------------------------efeqKVMLKQREKIHSKVVLDYAMKLAKFTRF------------------------ 161 Kluyveromyces l...
XP_001638176 279 ----Fqak----------------kkLTAIEKANKGSVSSEELIKYAHQISSSNAV------------------------ 314 starlet sea ane...
XP_001392945 113 dsdeNmdg----------------ekPRSTGLRGIKEVDYKLLLDFARRISKYNHQaaadaaataeaksrerlq------ 170 Aspergillus nig...
XP_001268437 111 yaidDadr----------------meTRPGGLRRTKEIDYKLLLDFARRISKYNHQaaadaaayavqeaqargkrl---- 170 Aspergillus cla...
Q2H2I4       148 sfrlqfqptqtqtptnsfnlsfngtvstpiglsaptptttndtqpstqlppsqqPPPKTAPAddKLPAHLKpav-nplHD 226 Chaetomium glob...
Q0V090       145 --------------------------------sgvntpahapaqpdsdapkdrdNADNKPAEvtAEEEEWLekl--qkSQ 190 Parastagonospor...
Q7SA34       148 eidsaaptpmpgggg-ggtataagtpaasaaptpaasgpsgpgpvttttapfsqPPPPPSANqtALPEDFKphi-nllTG 225 Neurospora crassa
Q54D00       191 ------------------------------------------------------------------PFGYQpn---apLA 201 Dictyostelium d...
Q2M0F9       138 ----------------------------------------------------------------SAPLTWC-------IG 146 Drosophila pseu...
Q23523       146 ----------------------------------------------------------------SAPLTWQ-------MG 154 Caenorhabditis ...
Q6CJA3       162 ------------------------------------------------------PPTFDKSM--IGPNNFI--------- 176 Kluyveromyces l...
XP_001638176 315 ------------------------------------------------------E----------APTTWM-------AG 323 starlet sea ane...
XP_001392945 171 ------------------------------------etkgpdtemtgtngnqdtEAAEPVASvtKDATSWLdesakmtRQ 214 Aspergillus nig...
XP_001268437 171 -----------------------------------pagdqdvamtgvnggpvteEGAEPVSSvtKEATSWLdesakmtRQ 215 Aspergillus cla...
Q2H2I4       227 AAFHPW-PTEGQIRTGALAALQRLVDagIEPRGYDPAEQERRRVAEEKArreaee-------------rarlerEE--AE 290 Chaetomium glob...
Q0V090       191 IAWYPW-PSEEKIRIGNLSKLMYWQArgKDVDDFDIPAHEEAQRKGLAG--------------------------V--VE 241 Parastagonospor...
Q7SA34       226 YQFHPW-PTEDKVRMGGMAAYQSLVSraVDPKGYDPEEEERRKKEEEEArkeaee-------------rairerEE--EE 289 Neurospora crassa
Q54D00       202 SLFKPPaPQDEMMRSSVLFTKPPPHVlkYYGLAEIDVTTPTMAANISSPfsigg----------------nvgdVT--TP 263 Dictyostelium d...
Q2M0F9       147 DLRRPY-PTDIEMRNGLLGKSDQNLNggQVPHQNSGLTPDVQRGLSGP------------------------------GG 195 Drosophila pseu...
Q23523       155 DPSRPF-PQEHEFRAGHLLNSKVQSTgpQLLPGKNVAQRPLITSPSASSsnggtapirtvgtplinsaptgdfsPR--TG 231 Caenorhabditis ...
Q6CJA3       177 -----W-PAEDSLRKGMLAMASLKKKelLLDALDEDNVNNDNNTSKIDE-------------------------MR--NT 223 Kluyveromyces l...
XP_001638176 324 DPRRPY-PLDIEMRSGLLGRLGEGVAmeTEIPTSTVGVAETSAVTAPVN-------------------------GV--Vd 375 starlet sea ane...
XP_001392945 215 AYMLPY-PMEDRIRMGLMAQIQLAAAe--gRPGFEPEKEVERLIREAEG-------------------------VG--IA 264 Aspergillus nig...
XP_001268437 216 AYMVPY-PMEDRIRMGVMGQIQLAAAe--gRPGFDSDKEVERLIREAEG-------------------------LGaaEP 267 Aspergillus cla...
Q2H2I4       291 RKGREERERMAREREA 306 Chaetomium globosum CBS 148.51
Q0V090       242 APPEPEPVAEPVQAQA 257 Parastagonospora nodorum SN15
Q7SA34       290 RRMREERERMARERER 305 Neurospora crassa
Q54D00       264 TSKEQEDQQQQQQQQQ 279 Dictyostelium discoideum
Q2M0F9       196 AGSGGAGEVPSAFQNQ 211 Drosophila pseudoobscura
Q23523       232 FGTDEPPPIQQQVLRG 247 Caenorhabditis elegans
Q6CJA3       224 NEDSVDDRFNNKEQVQ 239 Kluyveromyces lactis NRRL Y-1140
XP_001638176 376 gvangpsasslswqss 391 starlet sea anemone
XP_001392945 265 DAMPQVDVGEEARHad 280 Aspergillus niger CBS 513.88
XP_001268437 268 TAPAQAPVGEETRhan 283 Aspergillus clavatus NRRL 1
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap