4V1O


Conserved Protein Domain Family
Med17
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pfam10156: Med17 (this model, PSSM-Id:287165 is obsolete and has been replaced by 401965)
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Subunit 17 of Mediator complex
This Mediator complex subunit was formerly known as Srb4 in yeasts or Trap80 in Drosophila and human. The Med17 subunit is located within the head domain and is essential for cell viability to the extent that a mutant strain of cerevisiae lacking it shows all RNA polymerase II-dependent transcription ceasing at non-permissive temperatures.
Links
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Statistics
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PSSM-Id: 287165
Aligned: 28 rows
Threshold Bit Score: 308.472
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4V1O_W        11 LSSETGIKLALDPNLITLALssnpnsslhsptsdepvpesagkadtsirlegdelenktkkdndknlkflknkdslvsnp 90  baker's yeast
P87306         8 DADISSLSLSLDPEIIGG-------------------------------------------------------------- 25  Schizosaccharom...
Q7SI24        14 iiRTMDSPLNLRPRPPNS-------------------------------------------------------------- 31  Neurospora crassa
XP_007780565   3 TTESSTIQLSLRPAIA---------------------------------------------------------------- 18  Coniosporium ap...
XP_008086108   2 STTTNSFPISLRSWPSSK-------------------------------------------------------------- 19  Glarea lozoyens...
XP_001793136   2 sgYESLADVTLRPWPAAK-------------------------------------------------------------- 19  Phaeosphaeria n...
EHK45765      54 msSEGGPPLSLRPFPVAD-------------------------------------------------------------- 71  Trichoderma atr...
CCU77470       6 NTNEDDLLLSLGPDQTPS-------------------------------------------------------------- 23  Blumeria gramin...
XP_003843269   2 SSMESLRDVKLRPWPASK-------------------------------------------------------------- 19  Leptosphaeria m...
XP_002172173   5 SEKNDDFLLPIDPEALQDSL------------------------------------------------------------ 24  Schizosaccharom...

4V1O_W        91 HEIYGSMPLEQLIPIILRQR---GPgfkFVDLNEKELQNEIKqlgsdssdghN-------SEKKDTdga----deNVQIG 156 baker's yeast
P87306        26 QNNFLENNLQQIFQKIIQER---GP---FRDLKEEDLQKELQ----------KesikdesSAKSS----------ETENV 79  Schizosaccharom...
Q7SI24        32 ---RGPQTIADFIRRVNAEP---GG---FRALNEEEVRRNVI----------AernglhhEDVEMVt--------DQEAD 84  Neurospora crassa
XP_007780565  19 -ENNGAHTLAEQIWRINAER---GH---FRSVTEEGLRREIE----------Aqe------------------agLVETT 63  Coniosporium ap...
XP_008086108  20 --NSDATSLSTLFQRINGER---GG---IQGLTEESLRQEIA----------A-------EAETKMded----dtSENED 70  Glarea lozoyens...
XP_001793136  20 KEELSPQDLLLQIEQLGTER---GH---LRDVTEKSLQEDMA----------A-------GKGASEea-------aGSLE 69  Phaeosphaeria n...
EHK45765      72 ---QKPKNLAEFIARVNAQP---GG---FRSITEDKLREELR----------N-------SED-PDaad----dqDEEVS 120 Trichoderma atr...
CCU77470      24 ---INENSLADKISRINFQRaesGG---FRGLTEDNLREEIL----------G-------ERIVTKecs----esDGEST 76  Blumeria gramin...
XP_003843269  20 QGTLSQQKLYAQIEQLTTER---AH---LRDITKTALQEALG----------A-------GKDIPDgva----lkEKEDE 72  Leptosphaeria m...
XP_002172173  25 LAVDSENSLATVIPKIVKKY---GL---FRSLTESDLREKSE----------Q-------EEQSQEvqekakptpAKQPT 81  Schizosaccharom...

4V1O_W       157 EDFMEVDY----EDKdnpvdsrnetdhktnengetddnietVMTQEQFVKRRRDMLEHINLAMNESSLALEFVSLLLSSV 232 baker's yeast
P87306        80 LEFATLDSkrnvNDTeve--------------------------smDSQAYKKELIEQIMIAQTECSLALDMTSLLLSKF 133 Schizosaccharom...
Q7SI24        85 DDSKKPD----------------------------------------IIAARHNIIMSLGQAIQISSNFLDFISLLLSKE 124 Neurospora crassa
XP_007780565  64 EENDKEEE----EDK--------------------------VHTREGLAAARLELIRYVGQAYQEAAMALDMISLLLSKD 113 Coniosporium ap...
XP_008086108  71 EDEEQPDK------------------------------------LRELMEAKGEMLGLLESAYVSSAVTLDFLSLLQSKD 114 Glarea lozoyens...
XP_001793136  70 QKKKKKDA----TSR--------------------------EERLQEVLKAQHEMCMHMEWAKFAATNTVDLISLILSAD 119 Phaeosphaeria n...
EHK45765     121 EAAGEADV----AEK-------------------------------DPGVARMEVLKNIDIAGNAALLTLDSMSLLLSKQ 165 Trichoderma atr...
CCU77470      77 EEEEEPDR----I--------------------------------KELSIARQELLCQIDSAHQSAMFALDFISLALSKD 120 Blumeria gramin...
XP_003843269  73 EKKEKKEV----VTQ--------------------------KVTRETIFNAQREMYSHLEWAKFAATNALDLLSLVLSQD 122 Leptosphaeria m...
XP_002172173  82 AEEQGLD---------------------------------------NLSAHKKELIDQIAMAQNECSLALDMVSLLLSKY 122 Schizosaccharom...

4V1O_W       233 KESTGMSSMSPF-----LRKVVKPSSLNSDKIPYV------------APTKK--------EYIEL-DILNKGWKLQSLNE 286 baker's yeast
P87306       134 KEN-SIETISPF-----LKSTVPPSSLQFSRSQPP----------------E--------SKESD-ATLAKCWKEKSLTS 182 Schizosaccharom...
Q7SI24       125 IPTQAAVSISPW-----LRSQVPIGSIGATQLDAPt-----------PLTQS--------RVADN-KLITIGKRLVALNE 179 Neurospora crassa
XP_007780565 114 APAQGTQSMSPA-----LKSLVPPGTIHYEKWPPT------------QRTNA--------ELRNE-DVVTKGWKMQSLNA 167 Coniosporium ap...
XP_008086108 115 NPVQAASTMSQD-----IKLAVPTGTLGADKLNGP------------QINRA--------QMLDN-KRIAKGWKVQNVDK 168 Glarea lozoyens...
XP_001793136 120 PNRRSLANFSHSmqmqgLQQGLPFGAFGLGKESHV------------HHDRKhdeqdvlkEYAHRqELVSKGARMEALDR 187 Phaeosphaeria n...
EHK45765     166 NPTQAGLTLSQQ-----LRDMVGIGTLGADKLNDS------------NVTPA--------KTKDK-ESVAMGWTLLEINK 219 Trichoderma atr...
CCU77470     121 APTQAVSTISSE-----LREFVGLGTLGFDKLNAT------------RITDT--------KINEN-KQVVRGWQIQSLNK 174 Blumeria gramin...
XP_003843269 123 PNKRVASSFSHTfreqgLEQGIPFGSFGISKESHEyfvprpeeaerlEELAK--------KQL----LVAKGSRMEALDS 190 Leptosphaeria m...
XP_002172173 123 RTN-SVDTISPF-----LENAVSLGSLTMNRCEAP----------------K--------AKSSD-ALVGKLWKDKALKN 171 Schizosaccharom...

4V1O_W       287 SKDLLRASFNKLSSILQNEHDYWNKImqsISNKDVIFKIRDRTSGQKL--LAIKYGYEDSGSTYKhDRGIANIRNNIESQ 364 baker's yeast
P87306       183 SCKFLFEAKERLTSVVETEHEYYTEL---VKVKEASWPLFNS-QGSNH--LSVQYSCLGGISL-----GLGLIRMKPESK 251 Schizosaccharom...
Q7SI24       180 AADTALAAANRLRQEINSETKYWQEV---LTVSQKGWSTARLPQEPHD--MGVKFGFSNAAPLFK-NNSVAPLKRAEDGS 253 Neurospora crassa
XP_007780565 168 AADSLLVGAARLEKEVKKETKYWEQV---LSLSREGWAIRRVPQQKNV--LGVQIGCVDAAPRFK-SRGFSALRSNDEGD 241 Coniosporium ap...
XP_008086108 169 TIDSILNAATRFKNEVESETKYWEEV---VSVSEKGWSLCRLPSERHT--LGVRFGFLEASMTFR-NQSLAALRRNADGS 242 Glarea lozoyens...
XP_001793136 188 ATDDILKAARKLEKEVRRETKYWQEI---VSISDKGWPIQRHR---------IKADVWTASNHFK-ARGLAPLRMDKDGS 254 Phaeosphaeria n...
EHK45765     220 TRDSSEEAASFLEKEINSESKYWEDI---VGVKKAGWSISRVPQERHT--LGVRFGFSEAAAEFK-NNGLAPMRRGDDGS 293 Trichoderma atr...
CCU77470     175 TVDSILAAATRLEKEIESETRYWEQV---LDISNNGWAICCLPTEKQT--LGVRVGISDASPAFK-SRSLAALRRNHDGS 248 Blumeria gramin...
XP_003843269 191 AADEILKAAKKLEKEVRRETKYWQEI---VSVSDKGWPIQRLRQNARHvpFGVRFGLPEASDHFK-ARGFAPLRMSKDGS 266 Leptosphaeria m...
XP_002172173 172 ARTSFTAAAQRLRNVVEGEQEKWNLF---ARFHEKGWPILRGKDG--A--LCVQYSALGGQSV-----GVGTFDLSSKKG 239 Schizosaccharom...

4V1O_W       365 NLDLIPhsssvfkgtdFVHSVKKFLRVRIFTKiesEDDYILSGESVMDRDSESEEAetkDIRKQIQLLKKIIFEKELMYQ 444 baker's yeast
P87306       252 SFEVQS----------SLLYSQAALKISILNK---DRDEIGSSTWSWP--SQNCNS---VLLKDIYKLQEILFEMDIWNS 313 Schizosaccharom...
Q7SI24       254 VRLEYG----------RMGSKSERLQATL------LHNGEVVGRSSLP-RPLPDDA---PLDDRVKEARNTIFAQELWHE 313 Neurospora crassa
XP_007780565 242 IILDEA-----------LTQRPEAIRVRI------RHQDKIIGSSRLAAIDTKAQA---PVEELVHRARDTLFEQELYQE 301 Coniosporium ap...
XP_008086108 243 IFLDQG----------FTGSEPKILRVRV------QVGEIYTGTSQVP-KATGEDA---SVESLIQQARNTIFFTELWQE 302 Glarea lozoyens...
XP_001793136 255 IILD-P----------ALASKPKSLRVRI------RQDGNVTGTSHLPTAVGESDT---TIEKTIQRTRNSLFEEELFHE 314 Phaeosphaeria n...
EHK45765     294 ADLDFG----------RLGGVSEALVV---TY---EKDGKVIGRSTTR--PSSDDE---SLEARVLEARNTIFSQELWHE 352 Trichoderma atr...
CCU77470     249 IFLDQG----------ISGSDPQVIRVRI------ETNGSKTGSTTTP-LLVPDNA---PVQALILQARNTLFAEELWQE 308 Blumeria gramin...
XP_003843269 267 IILD-P----------ALALKPKTFRVRVTL------DGETTGTSQLSVQQDMKDN---SIEKSIQLARDSLFEEELYHE 326 Leptosphaeria m...
XP_002172173 240 KPTFVH----------GLQYEHASLKVDIH-R---RDEIVASNRWSWPDEHKTEED---DVEKQLHQARRTLFEMDVWNA 302 Schizosaccharom...

4V1O_W       445 IKKECALLISYG-VSIENeNKVIIE---------L-P-------N------EK-FEIELLSLDDDSIVNHEQDLPK---- 495 baker's yeast
P87306       314 LLQEAQSCGNQG-VNFTG-DEILVP---------I----------------SD-DHVVRITLETSSKNTESGFTEDkk-s 364 Schizosaccharom...
Q7SI24       314 INREGRTLHGHH-VRLEQ-SAVTCA---------LdP-------N------RT-ISFELVGLDDQDHSRAPL-------- 360 Neurospora crassa
XP_007780565 302 MILEARQLHGYY-IETRD-GVINVPakspkasntI-P-------DgskevtEH-ILIDKVYLDETLDDYDGH-------- 362 Coniosporium ap...
XP_008086108 303 LNRESRNLGGAD-VKATE-DSLILP---------L-N-------S------EKrIILDLVNIADL-----EAPAPQ---- 348 Glarea lozoyens...
XP_001793136 315 MSLEARQLMAHG-VDYRD-SIIHID---------A-SgsagqqrS------MT-LLIDCIPLEGPNPASQEH-------- 367 Phaeosphaeria n...
EHK45765     353 LTKESRSLAAYD-VKPEG-RKLACQ---------IdE-------T------TK-ITLELLPLESCPSPEQDM-------- 399 Trichoderma atr...
CCU77470     309 LQREARFLCSFGvSSTSS-TVTLTL---------T-P-------Q------KR-ALIDIVPLCAQSISESRG-------- 355 Blumeria gramin...
XP_003843269 327 MSMETRQLLAYG-VEFRD-SVIQLD---------V-PrmgntsqQ------LK-LLIDCIPRDEPIAESQSQ-------- 379 Leptosphaeria m...
XP_002172173 303 LLLEAQYCGNQG-VIYTG-NSIEVT---------YdG-------T------YK-TSISLSPVDSGADEHHKNDLSSdsmn 357 Schizosaccharom...

4V1O_W       496 INDKRANL--MLV------------MLRLLLVVIFKKTLRSR---ISSPH--Gl--INLNVDDDILIIRPILGKVRFANY 554 baker's yeast
P87306       365 NEDTSTNF--VTIkqekellkclcdTLNAIAHILFLKHCRKSdrrSQQPElyMa--IDANAP---LILRPLIFYYNLNQE 437 Schizosaccharom...
Q7SI24       361 PGDLDAET--ASI------------TLHLLLSNAHRQNQLKR-----SERtaAn--AMRGPPPPYNLLLPIITYYRHEKT 419 Neurospora crassa
XP_007780565 363 TQDAFAER--VAL------------ALRVLLAHGYRQRLHLRs-qVPPPM--TdkeRK---PPVTAILRPLLTVLQHWRD 422 Coniosporium ap...
XP_008086108 349 EDDHIAQG--LCL------------SLQLLLSYAHRQNHRRRt-lPPPPI--SgqkRTN---PPYNLLRPIITRLGHQRT 408 Glarea lozoyens...
XP_001793136 368 ANDWLAQN--IVE------------GLRLLLTHEQSMRLYRRt-qVPPPL--TgqkREKQSPS---LLRTLLAIFHHLQG 427 Phaeosphaeria n...
EHK45765     400 PENGLAEK--ISM------------ALHILLSYAHRYNELMRirpIPPHI--SrstRQQS----YALLRPVLARTMYLKN 459 Trichoderma atr...
CCU77470     356 KDDFFASG--IHT------------ALHLGLTWSHRLVRRRR---AQPPQ--Pv--tSNPLPEPCSLMRPILTRLVHERT 414 Blumeria gramin...
XP_003843269 380 SHNWLAQN--VAE------------GLRLLLAHEHSMRLYRRs-qVPPPL--TaraQEKPPPPLLRTLL---AVFRHLES 439 Leptosphaeria m...
XP_002172173 358 VDDKDVQLreLCL------------VFNTLIHVLFVQYCRE------TQK--FslkHLRQNPIPASILRPLIFLFSTNRL 417 Schizosaccharom...

4V1O_W       555 KLLLKKIIKDYVLDI 569 baker's yeast
P87306       438 SLEFQRWLKQRDISF 452 Schizosaccharomyces pombe 972h-
Q7SI24       420 LEDCTTFLAAFCGAL 434 Neurospora crassa
XP_007780565 423 VGLLREYLKTTCTAr 437 Coniosporium apollinis CBS 100218
XP_008086108 409 VNtlttllrdltsll 423 Glarea lozoyensis ATCC 20868
XP_001793136 428 VDSLYGYLNTVAETL 442 Phaeosphaeria nodorum SN15
EHK45765     460 VEESMQNMGLLVRTL 474 Trichoderma atroviride IMI 206040
CCU77470     415 ISEVIAFISPLTASL 429 Blumeria graminis f. sp. hordei DH14
XP_003843269 440 VDSLYVYLETLKRTL 454 Leptosphaeria maculans JN3
XP_002172173 418 AHSFQTWLQEHnipf 432 Schizosaccharomyces japonicus yFS275
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