Conserved Protein Domain Family
Mlf1IP
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pfam10248: Mlf1IP (this model, PSSM-Id:287250 is obsolete and has been replaced by 463022)
Myelodysplasia-myeloid leukemia factor 1-interacting protein
This entry is the conserved central region of a group of proteins that are putative transcriptional repressors. The structure contains a putative 14-3-3 binding motif involved in the subcellular localization of various regulatory molecules, and it may be that interaction with the transcription factor DREF could be regulated through this motif. DREF regulates proliferation-related genes in Drosophila. Mlf1IP is expressed in both the nuclei and the cytoplasm and thus may have multi-functions.
Links
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Statistics
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PSSM-Id: 287250
Aligned: 34 rows
Threshold Bit Score: 111.25
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q4V8X5        26 RSMFGSFGmDPFal-------------------------tPQIQ-HPRTRiqp-----qagALTPFG------MMGMggg 68  zebrafish
NP_995847     37 NRLMNSFMpDPF-------------------------------------------------------------------- 48  fruit fly
ERG82979      35 DRMMESMM-DPF-------------------------------------------------------------------- 45  pig roundworm
XP_006566701  28 NNMMNSLFnDPFgmmgh-------------------pshnAIAHaNHRNRnhq-----ddlQVLPFG------------- 70  honey bee
XP_001602461  28 NSMMNSMFaDPFglmgq-------------------mqqmQAPAiMDGHNphnrmvqmpgmQMMPFG------------- 75  jewel wasp
EFX89103      25 DSMMNSMM-DPFas-------------------------mMSMHhQMMGIqpppqqhhpagAMVPFGgmp-gfPMGMgms 77  common water flea
CDQ04592      31 ERMTHGML-NPFgsifnmhspfdsim----------------------gepsgtrpsrdlaLMDPFGfnf---------- 77  Brugia malayi
KKA70175      26 DQMMNQMM-DPFgvfgmaprhpfmasnaledgmqrsrgsaVAFPrQEm------------mMRDPFGfggfgaFGGMpdi 92  Pristionchus pa...
XP_003384339   4 RD-------DPFfrrqhfgpmsgs-----pfdihrhhgdhAVMRrEQRDPmfg------mmMMDPFAr------------ 53  Amphimedon quee...
XP_002113364  21 SARVNHF--NPFaqdpffnhsrs---------------------------aiamsnpmmmmPNNPFMame-nmMNNMmap 70  Trichoplax adha...

Q4V8X5        69 F-----------------MDMFSM--M----------------------------------S----G---MMENMERM-S 87  zebrafish
NP_995847     49 MqvspfdqgfqqnalmerPQMPAMpaM----------------------------------GlfgmP---MMPNFNRL-L 90  fruit fly
ERG82979      46 G-----------------MLSRHS--MyagmledanprqwvphrddmalmspfggfggglfG----G---VMRQMEDL-Q 98  pig roundworm
XP_006566701  71 F-----------------PPLPSFn-M----------------------------------G----N---MFSNFDNM-A 90  honey bee
XP_001602461  76 F-----------------PPMPSLn-I----------------------------------G----R---MFSNLNGM-S 95  jewel wasp
EFX89103      78 P-----------------FGMPS---V----------------------------------G----Q---MFQSF----- 91  common water flea
CDQ04592      78 -------------------------------------------------------------------cdgLMRQMENV-Q 89  Brugia malayi
KKA70175      93 F-----------------AQRRPRr-V----------------------------------F----GiprIFREMNGM-A 115 Pristionchus pa...
XP_003384339  54 --------------------------M----------------------------------Q----S---MMANFDNMfA 66  Amphimedon quee...
XP_002113364  71 F-----------------HNSLLG--M----------------------------------H----S---PMNDFRNL-E 89  Trichoplax adha...

Q4V8X5        88 ----G---SPN-CQT--FSSSTVISYSST-DPGT-PKVYQQTSEYRTAPggIRETRQTMRDSQSGL-ERMSIGHHIGERG 154 zebrafish
NP_995847     91 ----NadiGGNsGAS--FCQSTVMTMSSG-PDGR-PQIYQASTSTKTGPggVRETRRTVQDSRTGV-KKMAIGHHIGERA 161 fruit fly
ERG82979      99 svamN---DPN-SHV--FTQSTMITFDGR-NGGQ-PRIVEKSVRKTg---dVKETRESLRHGDIG--ERMSIEHTIGDRT 165 pig roundworm
XP_006566701  91 ----S---SGN-CHS--FVSNSVMTFG---SDGR-PQVYEETTSTTTVPggIKETKTTVCDSRTGK-KKMAIEHHIGDRA 155 honey bee
XP_001602461  96 ----N---DPN-CHS--FTSSSIMTMTSG-PDGR-PQVYQESMSSRTAPggVKETKKTVSDSRTGT-RKMAIGHHIGERA 162 jewel wasp
EFX89103      92 ----G---QPGfGASpmYSSSSVMTMTTG-PDGQ-PQVYQASTTTRTAPggVREVQRSVSDSRSGV-RKMAVGRHLGERG 161 common water flea
CDQ04592      90 tqamN---DPN-AHV--FSHSTMISFDGRnGGQ--PRVVEKTIRKtg---dVKETRHAIRTGEDGIgDKLTIGHTIGDRT 158 Brugia malayi
KKA70175     116 qaamN---DPN-GTV--YSSSTMISMD---GSGRaPRIVETSTRRsg---dVKETRRRVQNGDE---EEMVIGHTIGDRE 180 Pristionchus pa...
XP_003384339  67 a--aQ---EGRgGHS--YSQSTVMHFSSTnGRDGqPQIYQASSSTRCAPggIKESRKMERDSTTGV-QKTSVSHQIGDKS 138 Amphimedon quee...
XP_002113364  90 ----R---NAN-CHT--FSSSSIMTYSSNgGDGQ-PQIYQASSSTHSLPngIKKIRRTVKDSASGL-HKMAIGHHIGDRS 157 Trichoplax adha...

Q4V8X5       155 HVMERSRNRLTGDREERQDFFNLEESEAAAFDEEWRRE 192 zebrafish
NP_995847    162 HIIEKEQDMRSGQLEERQEFINLEEGEAEQFDREFTSR 199 fruit fly
ERG82979     166 HVIEKKRD-RDGRIREQQRFVNLGEDQAEDFDREFTTR 202 pig roundworm
XP_006566701 156 HILEREQNIHSGEQEEHQEFINLDEEEAESFNKEWESR 193 honey bee
XP_001602461 163 HIIEREQNYQSGDQEERQEFINLEEEEAETFNREWETK 200 jewel wasp
EFX89103     162 HVVEKEQNCYTGDSEEREDFINIEEEEAHQFDEEWRRR 199 common water flea
CDQ04592     159 HVIEKKRD-RDGRIRERQSFVNLAQDEAEAFDREFASR 195 Brugia malayi
KKA70175     181 HILEKKRD-KDGNVRNQQRFRNLDQAEAEAFDREFKTR 217 Pristionchus pacificus
XP_003384339 139 RTVQREVNLRTNEREENREYINLTEEDEPSFSREWDEK 176 Amphimedon queenslandica
XP_002113364 158 HTIEDARNMKTGSHEHVQNLVNLTEEDAETFDREWQQA 195 Trichoplax adhaerens
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