2LP1


Conserved Protein Domain Family
APP_amyloid

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pfam10515: APP_amyloid (this model, PSSM-Id:287486 is obsolete and has been replaced by 463129)
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beta-amyloid precursor protein C-terminus
This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, pfam02177, further towards the N-terminus.
Statistics
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PSSM-Id: 287486
Aligned: 20 rows
Threshold Bit Score: 69.2455
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2LP1_A        46 IVITLVMLKKK----QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFE 96  human
1507304C     111 IVITLVMLKKK----QYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFE 161 human
ABE73148      14 IVLSLLLLRKKk---PYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLE 65  Norway rat
XP_007660237 310 VVLSLLLVRRRr---PYGAISHGVVEVDPILNLEEPKPSALQPHGYENPTYRCLE 361 platypus
AAP22957     304 MVISLLLVRRK----PYGTISHGIVEVDPMLTPEERQLNKMQNHGYENPTYKFFE 354 zebrafish
XP_007442777 101 IVISLVMLRKR----QYGTISHGIVEVDPMLTPEERHLNKMQNHGYENPTYKYLE 151 Burmese python
XP_002613121 608 IIVALIVLRKKhapmRQPGVNHAVVEVDPSMTPEERHVSKMQQNGYENPTYKYFE 662 Florida lancelet
EFO18580     117 VVFAIVLIRQRp-------RRRGFIEVD-VCTPGERHVNGMQVNGYENPTYSFFD 163 eye worm
ERG82727     635 AVFAVLITRRRs-------RHAGFIEVD-VCTPEERHVNGMQVNGYENPTYSFFD 681 pig roundworm
NP_508870    637 IAFAITNARRRr-------AMRGFIEVD-VYTPEERHVAGMQVNGYENPTYSFFD 683 Caenorhabditis elegans
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