1M5I


Conserved Protein Domain Family
Suppressor_APC
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pfam11414: Suppressor_APC (this model, PSSM-Id:288297 is obsolete and has been replaced by 463275)
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Adenomatous polyposis coli tumour suppressor protein
The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Links
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Statistics
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PSSM-Id: 288297
Aligned: 30 rows
Threshold Bit Score: 70.3479
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1M5I_A          2 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLP-LTEn-fSLQTDMTRRQLEYEARQIRVAMEEQL 79   human
XP_008119758  190 EYDMLKRMQELERERDALLHGLEMVDRVRDWFQHHLLESQRRQKHMGaEA----NYFSDPYSTHSCLLLARIQEVNLCLK 265  green anole
EFX73731      309 DQSMLRRIHILEQERQVLTSGMQALDKARDWFNSQLIDVNERIKSFGkSSIgssDYSTDAASERLGFKISRIEEVSRQLL 388  common water ...
XP_002131251  555 DYNVLKLIQQLEQEKDVLLQGLDALERGRDWFQERISDVQEKQRLLSnNGM---KPTRDVTENDATVTQSRIDNLLTKVS 631  vase tunicate
XP_005339041   35 FFLWLQRMQALEREQDALWQGLELLEHGRAWFEDHLREAQQQQLHLGaLGE---NFLTDLHSEPGGPQLAQIQKVNICLQ 111  thirteen-line...
XP_003473796   32 FFLWLQRMQALERRQDALWQGLELLQQGQAWFREHLRAAQGQQLRLGaLGE---DFRADSHWEPFGPPLAQIQRVNICLR 108  domestic guin...
XP_006171828  131 SRATIRLLEELDRERCFLL-----EEKEKLWYYSQLQGLSKRLDELPhVETq-fSMQMDLIRQQLEFEAQHIRSLMEERF 204  Chinese tree ...
XP_006639972  165 grvtAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPrVETf--SMQMDLIRQQLEFEAQQLRSVMEERF 242  spotted gar
XP_011472584  184 grlsDHHLEELYKERNLLLGEIDREERERCWYFSQLEALSQKLSQLPrIDTf--SLQMDLIRQQLEFEVQQVRSVMEERF 261  Japanese medaka
XP_009075736  102 sRESTGYLEELEKERSLLLAELEKEEKEKDWYYAQLQNLTKRIDSLPlTENf--SLQTDMTRRQLEYEARQIRAAMEEQL 179  rifleman

1M5I_A         80 GTC 82   human
XP_008119758  266 NLL 268  green anole
EFX73731      389 VLI 391  common water flea
XP_002131251  632 EMS 634  vase tunicate
XP_005339041  112 NLI 114  thirteen-lined ground squirrel
XP_003473796  109 GLI 111  domestic guinea pig
XP_006171828  205 GTS 207  Chinese tree shrew
XP_006639972  243 GTS 245  spotted gar
XP_011472584  262 GSS 264  Japanese medaka
XP_009075736  180 GTC 182  rifleman
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