Conserved Protein Domain Family
Na_trans_cytopl

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pfam11933: Na_trans_cytopl (this model, PSSM-Id:288761 is obsolete and has been replaced by 403218)
Cytoplasmic domain of voltage-gated Na+ ion channel
This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.
Statistics
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PSSM-Id: 288761
View PSSM: pfam11933
Aligned: 40 rows
Threshold Bit Score: 113.237
Threshold Setting Gi: 733891677
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q16Z69        468 NKEKMSIRSEGL--ESVSEI------TRTTAPTATaAGTAKArKVSA-------------------ASLSLPGSPFNLRR 520  yellow fever ...
NP_001128390  500 NKERMSIRSVE--------SisehrvRISSNNHNVtSTTTKVrKVST-------------------ASLSLPGSPFNPRR 552  jewel wasp
XP_011266387  501 NKEKMSIRS----------IesvsdqRHLKQINNNhSAANKVrKVSA-------------------ASLSLPGSPFNLRR 551  Florida carpe...
XP_011266383  501 NKEKMSIRS----------IesvsdqRHLKQINNNhSAANKVrKVSA-------------------ASLSLPGSPFNLRR 551  Florida carpe...
XP_011266378  501 NKEKMSIRS----------IesvsdqRHLKQINNNhSAANKVrKVSAvpraangqftyayqeslrkASLSLPGSPFNLRR 570  Florida carpe...
XP_011266377  501 NKEKMSIRS----------IesvsdqRHLKQINNNhSAANKVrKVSAvpraangqftyayqeslrkASLSLPGSPFNLRR 570  Florida carpe...
XP_006561602  498 NKERMSIRSi----ESVSEH-------RVKQINNHtTTTKVR-KVSA-------------------ASLSLPGSPFNLRR 546  honey bee
EFA11577      520 NKEKISIRSEGL--DSVSEQ------RRVPTNLSKmR------KVSA-------------------ASLSLPGSPFNLRR 566  red flour beetle
XP_008200007  456 NKEKISIRSEGL--DSVSEH------RRV-------PNLSKIrKVSA-------------------ASLSLPGSPFNLRR 501  red flour beetle
NP_001188652  504 NKEKMSIRSVEVesESVSVI------QRQPAPTTA-HQATKVrKVST-------------------TSLSLPGSPFNIRR 557  fruit fly
Q16Z69        521 GSRGShQFTIRnGRGRfvgvpgsdrkplvlstylDAQEHLPYADDSNAVTPMSEENGAIIVPVy-yANlGSRHSSYTSHQ 599  yellow fever ...
NP_001128390  553 GSRGShQFTIRnGRGRfagppgsdrkplvlstylDAQEHLPYADDSNAVTPMSEENGAIVVPVyyaSLg-SRHSSYTSHA 631  jewel wasp
XP_011266387  552 SSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSEENGTIVVPVyyaNLg-SRHSSYTSHA 630  Florida carpe...
XP_011266383  552 SSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSEENGTIVVPVyyaNLg-SRHSSYTSHA 630  Florida carpe...
XP_011266378  571 SSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSEENGTIVVPVyyaNLg-SRHSSYTSHA 649  Florida carpe...
XP_011266377  571 SSRGShQFTIRnGRGRcfvppggdrkplvlstylDAQEHLPYADDSNAVTPMSEENGTIVVPVyyaNLg-SRHSSYTSHA 649  Florida carpe...
XP_006561602  547 SSRGShQFTIRnGRGRfvgppggdrkplvlstflDAQEHLPYADDSNAVTPMSEENGTIVVPVyyaNLg-SRHSSYTSHA 625  honey bee
EFA11577      567 GSRGShQFTLR-NNRRmvappgdrk-plvlstylDAQEHLPYADDSNAVTPMSEENGVMVLPMyytNLg-SRHSSYTSHA 643  red flour beetle
XP_008200007  502 GSRGShQFTIRnNR-Hmvggpcdrk-plvlstylDAQEHLPYADDSNAVTPMSEENGAMVFPMy-yANlGSRHSSYNSHA 578  red flour beetle
NP_001188652  558 GSRSShKYTIRnGRGRfgipgsdrk-plvlstyqDAQQHLPYADDSNAVTPMSEENGAIIVPVy-yGNlGSRHSSYTSHQ 635  fruit fly
Q16Z69        600 srisytshgdllg------------------------------------------gmtkesrlrnrsARntnhsivpppn 637  yellow fever ...
NP_001128390  632 srlsytshgdllgnvtkesrlrsrsarpp--------------------------------------------------- 660  jewel wasp
XP_011266387  631 srlsytshgdlafpgirgidsigkqltkqeqilrnrtnkqttpanghvtdtnqksyhfetdledpmgKT----------- 699  Florida carpe...
XP_011266383  631 srlsytshgdlafpgirgidsigkqltkqeqilrnrtnkqttpanghvtdtnqksyhfetdledpmgKT----------- 699  Florida carpe...
XP_011266378  650 srlsytshgdlafpgirgidsigkqltkqeqilrnrtnkqttpanghvtdtnqksyhfetdledpmgKT----------- 718  Florida carpe...
XP_011266377  650 srlsytshgdlafpgirgidsigkqltkqeqilrnrtnkqttpanghvtdtnqksyhfetdledpmgKT----------- 718  Florida carpe...
XP_006561602  626 srlsytshgdliggianagkpmtkesqlri-------rsvrppsvnghitdnnqkyhyegdledamgKA----------- 687  honey bee
EFA11577      644 srmsytshgdllgglgsngkmmtkesqlrnrs------------------------------------------------ 675  red flour beetle
XP_008200007  579 armsytshgdllgglv-----------------------------------gsgknmtkesqlrcrsMRnappattnsff 623  red flour beetle
NP_001188652  636 srisytshgdllggmav----------------------------------mgvstmtkesklrnrnTRnqsvgatnggt 681  fruit fly
Q16Z69        638 msgpnmsyvdsnhkgqrdfdmsqdctdeagkiKHNDNPFIE 678  yellow fever mosquito
NP_001128390  661 ----sangnhvtenlqkhhyvsegdtddsfskkQQDNPFIE 697  jewel wasp
XP_011266387  700 --------------------------------KQQDNPFIE 708  Florida carpenter ant
XP_011266383  700 --------------------------------KQQDNPFIE 708  Florida carpenter ant
XP_011266378  719 --------------------------------KQQDNPFIE 727  Florida carpenter ant
XP_011266377  719 --------------------------------KQQDNPFIE 727  Florida carpenter ant
XP_006561602  688 --------------------------------KQQDNPFIE 696  honey bee
EFA11577      676 -lrngpaaaplnhkstrgvydgptghiceskvkQIDNPFID 715  red flour beetle
XP_008200007  624 eithka---------hrgdydgptgqlcesklKQLDSSFID 655  red flour beetle
NP_001188652  682 tcldtnhk-----ldhrdyeiglectdeagkiKHHDNPFIE 717  fruit fly
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