Conserved Protein Domain Family
Med12-PQL

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pfam12144: Med12-PQL (this model, PSSM-Id:288958 is obsolete and has been replaced by 463471)
Eukaryotic Mediator 12 catenin-binding domain
This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.
Statistics
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PSSM-Id: 288958
Aligned: 15 rows
Threshold Bit Score: 210.807
Created: 14-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDM14847      850 MMHHTQPALWGYNlVSQPQQPSFFLQNQSLNA----------GGSRLDPagSFV-PtNTKQalSNMLQRRSGAMLQPPSL 918  Norway rat
XP_004940693 1964 LLHHQAGSTMSRL-AYGQSPVGLYAQNQPLPA----------GGPRLDT--SYR-P-VRMPl-GKLVQSRPPYSGVLPSG 2027 chicken
XP_006633104 1806 MLHGQQGHPFNRM-VYGPQSMGMYPQNQPLPPvpalksvsasGGPRLDT--TYR-P-TR------TLPMRPNRPAAYPNM 1874 spotted gar
XP_010737269 1792 ppdlmQTHPYGRM-PYGQQGMNMYTQNQPLPP----------GGPGLEP--PYR-P-TRNPpiNKMMPTRPNYPGMMPGM 1856 large yellow ...
XP_005467433 1792 LMQNPTYART--M-PYNPQ--NVYTQSQPLPP----------GGPGLDA--PYRqP-TRNQi-PKMMPARTNYPTMMPGM 1852 Nile tilapia
XP_006005514 1827 LLHHQPMHPYSRV-NYGQSSMGVYTQNQPLPA----------GGPRLDA--TYR-PsARVP--MKI-SNRPPYSGIMPPV 1889 coelacanth
XP_011478197 1784 LMQNPQ---YVRT-LYNQQQP-MYPQNQPLPP----------GGPGLEP--PYR-P-SRQP--SKMMPPRPNYPGMMPGM 1842 Japanese medaka
XP_012408847 1646 LLHHAPGSSISRF-GYPQTPVTLYTQNQPLPA----------GGPRLDT--TYR-P-VRMP--VPKLQTRPSYSGVLPSP 1708 Tasmanian devil
AAH57119     1790 LLHHANPGSISHL-SYRQSSMGLYTQNQPLPA----------GGPRVD---PYR-P-VRLP--MQKLPTRPTYPGVLPTT 1851 house mouse
XP_008119976 1807 LLHHQTANSMSRL-AYGQSPVGLYAQNQPLPA----------GGPRLDT--SYR-P-VRMPqiGKLVPSRPPYTGVLPTS 1871 green anole
EDM14847      919 HAVts-----qQQLLQMK-LLqq-qQQQ-QQQQQQQQQQqrllrqaqtrpfQQGQ-PGD--Q-AA--LFT-AQ-ARPSPQ 982  Norway rat
XP_004940693 2028 MGS--------MMGIDPS-YKpavyRQQ-PPVSQGQILR------------QQLQ-AKL--QgQG--IMG-QQtVRQMAP 2079 chicken
XP_006633104 1875 MTGmpggvgnlITALDQQ-AYra-yKPQ-PPI-QGQILR------------QQLQ-A----N-QG--MLG-QQ-VRQMPP 1928 spotted gar
XP_010737269 1857 QGSmp-----gMMGLEKQ-YPmg-yKPQ-P-MAQGQMLR------------QQLQ-VRL--N-QS--MIG-QQ-IRQITP 1907 large yellow ...
XP_005467433 1853 PGSmp-----gIMGPDKP-YQmt-fKPH-ATMPQAPNLR------------QQLQ-VRL--H-QNpnALG-Q--IRQMPP 1905 Nile tilapia
XP_006005514 1890 MPGig-----gIMSLDQQsYKqggyRPQ-PPPSQGQLLR------------QQLV---Q--N-QA--MGS-H---RQMNP 1939 coelacanth
XP_011478197 1843 QVNmp-----gIIGMEKQ-YPgn-yKPQ---MARGEILR------------HHLQ-LRLq-N-PG--MHG-QQ-LRQMAP 1893 Japanese medaka
XP_012408847 1709 ITg--------VISIDPS-YKtpvyRQQ-QPPVPQGQLL------------RQQLqAKL--S-QG--MLG-QPpVRQMTP 1760 Tasmanian devil
AAH57119     1852 MST--------VMGLEPSsYKtsvyRQQqPTVPQGQRLR------------QQLQ-AKI--QsQG--MLG-QSsVHQMTP 1905 house mouse
XP_008119976 1872 MSS--------MMSIDQA-YKssvyRQQ-QPPVPQGQLL------------RQQL-QAKlqG-QG--MVGpQP-LRQMAP 1924 green anole
EDM14847      983 LPQYPGLQQqaqtmPQGYTMYGTQMPLQQAAQqqPGGVVLSPSYSSRAYPAAH--SSPALMERLRQLQQQPGGYVQQQAS 1060 Norway rat
XP_004940693 2080 TPSYGALQP-----SQGYTPYVSHIGLQQHPS--QSGTMVPPTYSGQPYQNSHpsSNPALVDPVRQMQQRPSGYVHQQAP 2152 chicken
XP_006633104 1929 NPSYGTLQPtqvppPQGYTSYGPHMGMQQHPS--QTGGMVPPAYANQPFQGSHpaPNPAMVDSLRQMQQRPSGYIHQQAP 2006 spotted gar
XP_010737269 1908 NQPYTSMQAsq-niSQGYTTYGSHMGMQQHQT--QSGGIVPSSYGNQNFQGTHpgANPGVVDPLRQM-QRPPGYVHQQAP 1983 large yellow ...
XP_005467433 1906 NQQYTSMQT-----SQGYTTYGSHMGMQQHPS--QSGSIVPHSYGNQNFPGAHpgANPAVVDPLR--QQRPSGYLLQQAP 1976 Nile tilapia
XP_006005514 1940 TSSYGSLQa-----PQGYTPYGSHLGLQQQLP--QAAGMVLPTYSGQAFp----gSNPALIDSVRQIQQRPSGYVHQQAP 2008 coelacanth
XP_011478197 1894 -SQYPPMQa-----SQGYTTYQSNMSMQQHPS--QGAGIVPSSYGNPSFQGTHpgANPPVVDPLRQMPPRPSGYVHQQAP 1965 Japanese medaka
XP_012408847 1761 NSSYGSLQa-----SQGYTPYGSHIGLQQHTG--PAGTMVPPSYSSQPYQSPHpaANPTLVDPARHLQQRPSGYVHQQAP 1833 Tasmanian devil
AAH57119     1906 SSSYG-LQT-----SQGYTSYVSHVGLQQHTG--PAGTMVPPSYSSQPYQSTHpsTNPTLVDPTRHLQQRPSGYVHQQAP 1977 house mouse
XP_008119976 1925 TPSYGAVQP-----SQGYTPYVSHIGLQQHPS--QSGAMVPPSYSSQTYQNAHpgSNPTFVDPTRTM-QRPSGYVHQQAP 1996 green anole
EDM14847     1061 PYLQPVAGSQRLNHQ 1075 Norway rat
XP_004940693 2153 GYGHTLGNTQRFPHQ 2167 chicken
XP_006633104 2007 GYVHAMQNTPRFAHQ 2021 spotted gar
XP_010737269 1984 GYAHNMQNTQRFAHQ 1998 large yellow croaker
XP_005467433 1977 GYPQSMQNTQRFPHQ 1991 Nile tilapia
XP_006005514 2009 GYSHSLQNPQRFTHQ 2023 coelacanth
XP_011478197 1966 GYAHTMQNPPRFANQ 1980 Japanese medaka
XP_012408847 1834 GYGHGLPTTQRFAHQ 1848 Tasmanian devil
AAH57119     1978 TYGHGLTSTQRFSHQ 1992 house mouse
XP_008119976 1997 GYVHSLSAAQRFPHQ 2011 green anole
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