Conserved Protein Domain Family
Med12-LCEWAV

?
pfam12145: Med12-LCEWAV (this model, PSSM-Id:288959 is obsolete and has been replaced by 463472)
Eukaryotic Mediator 12 subunit domain
This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. The function of this particular region of the Mediator subunit Med12 is not known, but there is a conserved sequence motif: LCEWAV, from which the name derives.
Statistics
?
PSSM-Id: 288959
Aligned: 15 rows
Threshold Bit Score: 580.132
Created: 21-Jul-2015
Updated: 5-Aug-2015
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q2LZZ5        393 DFVQSERLCRKMAYIVSKKLAQLLNAAVEQQGIK--------DVDGGVGagaggg-----enklqhDPFELALQEQMSCP 459  Drosophila ps...
Q8BQM9        283 EFVQSAYLSRRLAYFCARRLSLLLSDSP--NLLAahsphmiiGTNNTSIgtpspg-----tpgpgmSPVQLAFSDFLSCA 355  house mouse
Q2QCI8        285 EFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPGPGghqa-hgiSAQQGNAlpptpt-----sqpaggNQPQTPFTDFYICP 358  zebrafish
Q7YQK8        133 EFVQSAYLSRRLAYFCTRRLALQLD------GVSshss-hviSAQSTSTlpttpa-----pqpptsSTPSTPFSDLLMCP 200  chimpanzee
XP_008119976  286 EFVQSAYLSRRLAYFCTRRLAMLLDST------Gghqa-hhlSAQAAPPlpstpt-----pqpaagNPPPSPFSDLLLCP 353  green anole
XP_005996537  283 EFVQSAYLSRRLAYFCTRRLSLMLSESPNLISAHsph--viiGSNNLPLaapspt-----ttgavvSPMQSAFSDFLSCA 355  coelacanth
XP_006570939  336 EFVQSELLARRLAYLCCRKLAHMCNNVETNANPQsp----tiSKNDVNIgkdtai------anqiqNPLTIAFNDYLSCP 405  honey bee
XP_012824462  327 sLVQSAYLSRRLAYFCTRRLAQLLEGS------Gshpg-hlmTAQTGTAlppapa-----ppppsgSAPSSPFSDLLQCP 394  western clawe...
XP_008194002  288 EFVQSELLSRRLAHLCCKKLGYMLNNVAENNLi---------TSPQSETkteqkdnekekkdvpvtNPMQSTLMEYQNCP 358  red flour beetle
XP_008182494  286 EFCQSELLSRKLVYFCSRKLNTICNSVIDLNPPQspts-kgaSNNSVPSntss------------atnaASTLNDMMSCP 352  pea aphid
Q2LZZ5        460 HHRDIVLYLSTILQIITIECPTALVWS-G-IAAHRAPSSLVGSPLDHLPLAPSVLPMPTRCPRTNTEIRRQLRAAESEIV 537  Drosophila ps...
Q8BQM9        356 QHGPLVYGLSCMLQTVTLCCPSALVWNyS-TNENKISNP--GSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIK 432  house mouse
Q2QCI8        359 QHRPVVFGLSCMLQSIVLCCPSALVWHyS-LTDSRNKT---GSPLDLLPIAPSNLPMPGGNSTFNQQVRAKVREIEEQIK 434  zebrafish
Q7YQK8        201 QHRPLVFGLSCILQTILLCCPSALVWHyS-LTDSRIKT---GSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIK 276  chimpanzee
XP_008119976  354 QHRPVVFGLSCILQSIVLCCPSALVWHyS-LTDSRIKT---GSPLDHLPIAPSNLPMPGVNTGFMQQVRAKLREIEQQIK 429  green anole
XP_005996537  356 QHRPLIYGLSCMLQTITLCCPSALVWN-YyTSESKSSNP--GSPLDFLQVAPSSLPIPGGNSVFNQQVRAKIHEIEQQIK 432  coelacanth
XP_006570939  406 HHRDVIYSLSTIIQVITLECPTALVWN-S-VGEGKAPSVLNGSPLDYLQCPPTALPCPPVS--ATNPIIKQLKIAQKNIR 481  honey bee
XP_012824462  395 QHRPLVFGLSCMLQSIVLCCPSALVWHyS-LTDNRIKT---GSPLDHLPIAPSSLPMPGGSSAFTQQVRRKLRDMEQQIK 470  western clawe...
XP_008194002  359 HHRDIVLQLSTVIQTITLECPTALVWC-G-TGVG---SVWHGSPLDLLPMVPSSLPMAARC--DMNTYRKQLQFAEHCIR 431  red flour beetle
XP_008182494  353 HHRDILLPLSCIIQVILLECPTSLIWN-H-SGGGKLPSVLNGSPLDYLPCSPVVLPMPQR--TNNIPLRKQLKQAEEIVK 428  pea aphid
Q2LZZ5        538 LRTQHAEQRWFASKWLsAGKNH-YTKVLATLDHLDTHCFDRMEQCNSIDTLYVHIFPrrr------------------de 598  Drosophila ps...
Q8BQM9        433 QRGRAVEVRWSFDKCQeSTAGVtISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWanqnk------------------ 494  house mouse
Q2QCI8        435 ERGQAVEFRWSFDKCQeTTAGFtISRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGsgqsk------------------ 496  zebrafish
Q7YQK8        277 ERGQAVEVRWSFDKCQeATAGFtIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGlgpsk------------------ 338  chimpanzee
XP_008119976  430 ERGQAVEVRWSFDKCQeATAGFtIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGagp-------------------- 489  green anole
XP_005996537  433 QRGRAIEVRWSFDKCQeSVAGFpIYKVLHILEVLDRHCFDRSDSSNSLDTLYHKIFWpnq-------------------- 492  coelacanth
XP_006570939  482 ARSQAAEGKWSCDKWQqSSAGItTTKVLAALDALDRHSFDRMDSSNSLDTLYAKIFTsplk---------------dnan 546  honey bee
XP_012824462  471 ERGRSVEVRWSFDKCQeATAGFpIGRVLHTLEVLDSHSFEKSDFSNNLDSLYNRIFGlgl-------------------- 530  western clawe...
XP_008194002  432 ERSKRAEGRWCTEKWQnSSAGTiTNRVLAALDALDRHRFDKMDSTNSLDTLYTKVFGg---------------------- 489  red flour beetle
XP_008182494  429 IRSQAAEGRWCLDKFHkSSIGAkTIKILNVLDALDRHSFERIDQNNSLDTLYNKIFLppnskdnsnpllgnismstenet 508  pea aphid
Q2LZZ5        599 DQqdpqqqqQPRPVYEPKQDKDTVRILCEWAVSSQRWGEHRAMVVANLLDKRQIDVTSTPSEQS------SDKEDK-DSL 671  Drosophila ps...
Q8BQM9        495 -----------dnqevAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGES------EVLDEK-ESI 556  house mouse
Q2QCI8        497 -----------dghemSPDDDAVVTLLCEWAVSCKRSGPHRAMVVAKLLEKRQTEIEAERCGES------EVVDEK-GSV 558  zebrafish
Q7YQK8        339 -----------dgheiSSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGES------EAADEK-GSI 400  chimpanzee
XP_008119976  490 ---------skDSHEISPDDDAVVALLCEWAVSHKRSGRHRAMVVAKLLEKRHSEIEAERCGDS------EVVDEK-GSI 553  green anole
XP_005996537  493 ---------skDSQEILPNGEAVVTLLCEWAVSCKRFGKHRAVAVAKLLEKRQVEVEAERCGES------EVLDEK-ESI 556  coelacanth
XP_006570939  547 ER-------DTKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEVT----GET------NDNDDK-DSI 608  honey bee
XP_012824462  531 ---------gkDGHEISPDDDAVVTLLCEWAVSCKRYGHHRALVVAKLLEKRQAEIEAERCGDS------EAVDEKgSVS 595  western clawe...
XP_008194002  490 ---------------NSDQENSVVKLLCEWAVSPERTGEHRALAVAALLDRRQSDSATNGDQET------APGDDK-DSN 547  red flour beetle
XP_008182494  509 LK-------DNRSEYNVEQDQIVVKVLCEWALSSLRRGEHRGMAVARLLDKRQAEITGRESDSSvevvpgGPSEDK-DSI 580  pea aphid
Q2LZZ5        672 ASG-AGLIDGLPVFQHVLMHFLDHDAPVLDDhLSSAQQRTEFTNLVQLFSALIRHDVFSHNAYMHTLISRGDLLSLES-- 748  Drosophila ps...
Q8BQM9        557 SSAsL-AGSSLPVFQNVLLRFLDTQAPALSD-PNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDL-SVTA-- 631  house mouse
Q2QCI8        559 SSGsLSAATL-PVFQDVLLQFLDTQAPVLTE-PGNESERVEFSNLVLLFYELIRHDVFSHNIYMCTLISRGDLASNSH-- 634  zebrafish
Q7YQK8        401 ASGsLSAPSA-PIFQDVLLQFLDTQAPMLTD-PRSENERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAP-- 476  chimpanzee
XP_008119976  554 SSG-SLSAVNAPVFQDVLMQFLDTQAPMLTE-PANENEKVEFFNLVLLFCELVRHDVFSHNMYMCTLISRGDLAIDHG-- 629  green anole
XP_005996537  557 SSV-SLAGSSLPVFQNILLKYLDTQGPVLTD-PNNETEKTEFINLVLLFCEFIRHDVFSHDAYMCTLISRGDLSSMIS-- 632  coelacanth
XP_006570939  609 CSN--GNPPVLPIFQSLLMKFLDMDAPVLD--NTTTQSKVQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPA-- 682  honey bee
XP_012824462  596 SGS-LSALSAPPVFQEVLLQFLDTQAPMLTD-PANESERVEFYNLVLLFCELIRHDVFSHNMYMCTLISRGDLGIDPH-- 671  western clawe...
XP_008194002  548 CSV----PGGPPMFQQLLMKFLDSDAPVPAP-DDCPQKKTAFSNLVHLFAELIRRDVFSHDAYMCTLISRGDLL------ 616  red flour beetle
XP_008182494  581 VST----PATLPLFQPLLMNFLDHDAPVLE---NTSTSRTTFTNLVHVFTELIRNDVFSHDAYMCTLISRGDLQSTNNig 653  pea aphid
Q2LZZ5        749 ----VlASKasttatksspaaaatqATTTHGFDDDPFGGGI--DFK---------HNEFD---DS--NVDDDLDK----- 803  Drosophila ps...
Q8BQM9        632 ----S-TGLrsp----------ageNSDEHYSKDHDMKMEI--FSPmpg----escENINpslSR--RLSVNGEK----- 683  house mouse
Q2QCI8        635 ----L-PRPrsp----------sdePSDESERKDQDAGSSV--KMEdtg---mseSMEIDh-nSS--ANFDEMfsppmhc 691  zebrafish
Q7YQK8        477 ----G-PRPpsp----------fddPADDAEHKEAEGSSSS--KLEdpg---lseSMDIDp-sSS--VLFEDMEK----- 528  chimpanzee
XP_008119976  630 ------PRPpsp----------fddAAEDHDRKEGEGNSGI--KLEdtgl--secQMDIDh-nSS--AIFDDMEKtdfsm 686  green anole
XP_005996537  633 ----A-AGPrsp----------ageNPSEHYRKDHELKQ------Edhg---lgeHMDMD---SGttNLFDEVDK----- 680  coelacanth
XP_006570939  683 ----Askp---------------gtPNNREPIDEECLFPGIetKLEvsd---hgrTMDYD---DS--KIDDDLDK----- 730  honey bee
XP_012824462  672 ----A-PRPrsp----------yedPSDDTDRKEGEANSSI--KLEdtt---lseTMDIDh-gSG--ALFEDMEK----- 723  western clawe...
XP_008194002  617 -----------------------------GPEETTDVSTSH--QSHhtkledhshNMDFD---DA--TIDHDLDK----- 655  red flour beetle
XP_008182494  654 mcqpGsNKPadtps-------gagpSQAQVHMEDDNLF-----DLKpnvpehhnrHMDYD---DS--KIDDDLDK----- 711  pea aphid
Q2LZZ5        804 -------------L------------------VQNIKEKGQHD--APDSPKigppGDG---------------------- 828  Drosophila ps...
Q8BQM9        684 -------------L---------------------LKREKPREl------------------------------------ 693  house mouse
Q2QCI8        692 -------------------------eskgspsPEKQAQEQESKs------------tA---------------------- 712  zebrafish
Q7YQK8        529 -------------PdfslfsptmpcegkgspsPE--KPDVEKEv-----------kPP---------------------- 560  chimpanzee
XP_008119976  687 fsppmhceakaspS------------------PEKLDPEKESK--L---------LLL---------------------- 715  green anole
XP_005996537  681 -------------S--------------------DFKTDFSSEf-AIFSPM----PGEpltyenvncldrriavieemaw 722  coelacanth
XP_006570939  731 -------------L------------------LQHIKEDQQNSmdAPDSPK----EDAl--------------------- 754  honey bee
XP_012824462  724 -------------Sefpmfspam-rcegrspgPEDGDRDIRRT--V---------------------------------- 753  western clawe...
XP_008194002  656 -------------I------------------LQNIKEDQQNSmdVPDSPKe---HDH---------------------- 679  red flour beetle
XP_008182494  712 -------------L------------------LQHIKEEQQNSmdAPDSPK----VEP---------------------- 734  pea aphid
Q2LZZ5        829 -EP--STGGAGGSI--------------SRHYVYTKHFPIPQD-E--SS-YssESNQRYILL 869  Drosophila pseudoobscura
Q8BQM9        694 --------iFPSNYd------------lLRHLQYATHFPIPLD-Es-SS-H--ECNQRTILL 730  house mouse
Q2QCI8        713 -KDkgMDPAFPLVYe------------qPRHIQYATHFPIPQE-Es-AS-H--ECNQRLVVL 756  zebrafish
Q7YQK8        561 -PKekIEGTLGILYd------------qPRHVQYATHFPIPQE-Es-CS-H--ECNQRLVVL 604  chimpanzee
XP_008119976  716 -KDraADGLLASLYd------------qPRHIQYSTHFPIPQE-Es-SS-H--ECNQRLVVL 759  green anole
XP_005996537  723 rTEkqKELVFSSTYd------------lPRHLQYATHFPIPLD-Ds-SS-H--ECNQRVILL 767  coelacanth
XP_006570939  755 -AGhgTQEGLDSKIps----------shSRHLLYTTHFPLPQD-Et-CSqH--DCNQRHVLL 801  honey bee
XP_012824462  754 -KGlnGEGPLSALYd------------qPRHIQYATHFPIPQE-Es-CS-H--ECNQRLVVL 797  western clawed frog
XP_008194002  680 -GHhpHQSSIGHVPmetdhn--dhkvkpSRHLLYTTHFPLYQD-DpfSQ-H--DCNQRHVLL 734  red flour beetle
XP_008182494  735 -FAgsSIGGLESNDpstntndnmykcrpSRHLLYATHFPLPLDeEt-TS-H--DCNQRHVLL 791  pea aphid
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap