Conserved Protein Domain Family
Hydrolase_4
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pfam12146: Hydrolase_4 (this model, PSSM-Id:288960 is obsolete and has been replaced by 463473)
Serine aminopeptidase, S33
This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.
Links
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Statistics
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PSSM-Id: 288960
Aligned: 95 rows
Threshold Bit Score: 174.702
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q250S9        24 AHPKAVVMICHGYAEHSSFYVQFMEFLAEHGYGAYALDHRGHGHS-----E-----AERGHLDRFEVFLEDLDVFVDHVR 93  Desulfitobacter...
Q6CZI2        66 PQHDKIVVVFSGRIESYVKYSEVAYDLFHRGYDVLIMDHRGQGRS-----GrvlqdGHRGHVQRFSDYVDDAETLCQQHI 140 Pectobacterium ...
P07000        51 QHHDRVVVICPGRIESYVKYAELAYDLFHLGFDVLIIDHRGQGRS-----GrlladPHLGHVNRFNDYVDDLAAFWQQEV 125 Escherichia col...
P44800        45 SAVRKLMILVNGRAENMLKWSELAYDFYHQGYDVLLFDHRGQGYS-----Qri--iPQKGHLDEFRFYVDDMAKIIEKVT 117 Haemophilus inf...
Q47VY9        50 QVECPTIVIVPGRCESYLKYQELSFDLYQQGYNIFIIDHRGQGLS-----GrmllnVNKGYVTKFQDYVDDLRYFIENIV 124 Colwellia psych...
Q6LVU9        53 YNHDKAIIVVNGRIESYWKYQELFYDLVKQGYDVYAIDHRGQGIS-----DrlakdNELGHVEEFDDYVTDLKTFFDTVV 127 Photobacterium ...
Q5QYM1        55 SDSAPLVVIAPGRIESALKYQELFWELAQQGFSVAALDHRGQGLS-----GrltanPHQGHVENFNDFVRDFSDFTNLLV 129 Idiomarina loih...
Q8E8D2        47 PKAHASIVISSGRVESYLKYQELIFDLYQQGYSVFAIDHRGQGLS-----SrmtanPHQGHVRRFNDYIDDFALFMQTVV 121 Shewanella onei...
WP_023283109  51 QHNDRLVLICPGRIESYVKYAEVAYDLFHCGFDVMIIDHRGQGRSgrllsD-----THRGHVVNFSDYVDDLAALWQQQV 125 Klebsiella pneu...
WP_001067680  52 PEHQKAVVIVNGRIESAWKYQELCYDLFRQGFDVYTYDHRGQGRS-----ErltedRQIGHVHEFQDYVTDLKALVEHFD 126 Vibrio cholerae

Q250S9        94 ELHPTQPLFMFGHSMGGLISFNYG--ILHPGKLQ-GQIFSGAAlarpvgt---------eyiptfLFKLLNV-------- 153 Desulfitobacter...
Q6CZI2       141 EPTRYTRRFALAHSMGGAILAQLL--VRQPA-MFdAAALCAPMfgirlplphcv---------------------aewiv 196 Pectobacterium ...
P07000       126 QPGPWRKRYILAHSMGGAISTLFL--QRHPG-VCdAIALTAPMfgivirmpsfm---------------------arqil 181 Escherichia col...
P44800       118 ALFSYSTQHLLAHSMGALIATYYLanYDHHIn---KAVLSSPFygillkhp------irdeliitLMNILGQ-------- 180 Haemophilus inf...
Q47VY9       125 TPKSSEKPYLLAHSMGGTIATRFM--QDSPN-AIkAAVISSPMlgfysgllpksiakilvaiklkFNNIISN-------- 193 Colwellia psych...
Q6LVU9       128 TPKKYQQHFLLGHSMGGTISTLFL--AKYPS-LIkRAVLSAPMhgiqlsnwmkp---------------------iaspf 183 Photobacterium ...
Q5QYM1       130 ARFGDVPKTLFSHSMGGTIATIYCatYQHPYk---KLILSAPMfsietgivpywfarwivfagawLNRWLAK-------- 198 Idiomarina loih...
Q8E8D2       122 LKHATSPLFLLGHSMGGAIGTLYL--KQHPD-VFtAAVFSAPMygiklpm--------pkgfvrwLASKLDT-------- 182 Shewanella onei...
WP_023283109 126 VPGHWRKRFILAHSMGGAIATLFL--QRYRAHCD-AIALCAPMfgiiirlp-------dwmvrhiLDWAEGHqrireeya 195 Klebsiella pneu...
WP_001067680 127 LGHYQE-RFLLAHSMGGAIATRYI--QTTPAHPFsALALSAPMfgvnmpwylrp---------------------walli 182 Vibrio cholerae

Q250S9       154 ----VLKRLRI-----------------RPKLSGKTTRNMAVRKISDGDS-LVlRYATLGFFYQFACRGVAFAQEKAGRY 211 Desulfitobacter...
Q6CZI2       197 dwaerHPAIRDyyaigtgq--wrplpyrMNVLTHSRERYQRSIRFYADSP-DLrVGGPTYHWVREAILAGKYLLTQASAV 273 Pectobacterium ...
P07000       182 nwaeaHPRFRDgyaigtgr--wralpfaINVLTHSRQRYRRNLRFYADDP-TIrVGGPTYHWVRESILAGEQVLAGAGDD 258 Escherichia col...
P44800       181 ----GERyvfgkga-------yqqahleYNELTFCKTRMKWMNRINRKNP-AInLGGPTFRWVHLCLNAIKRLPKVIPKI 248 Haemophilus inf...
Q47VY9       194 ----T-----Pwyflgqkd--yspvnftDNKLTHSIPRYQYFVDLYKKNK-IIqLGGVTTHWLAQSIAAQKELFSKIVQL 261 Colwellia psych...
Q6LVU9       184 arvveqLQRQPnyapgqvp--yypkpflNNKLCQSQIRYQWFRDLYEHKP-ALkIGGPSARWVWQGMAAANRCITQAANI 260 Photobacterium ...
Q5QYM1       199 ----------Pwyflgmgn--ykpvpfeENVLTHSRQRYKAFRDAYDNVS-DVqLGGPTFNWLYEAISAAINAQKLANDI 265 Idiomarina loih...
Q8E8D2       183 ----SLNGGEPnyvlsgqnykavpvpfkGNDLTHCQSRYQAYRELYEAAP-KLqLGSPTNRWLTESLDAADACVLATTHI 257 Shewanella onei...
WP_023283109 196 igtgRWRALPFa----------------VNVLTHSRQRYRRNLRFYADEPrLQ-VGGPTWHWVREGMLAGDEVLANVEKD 258 Klebsiella pneu...
WP_001067680 183 tqimaaVTLKPsyapgygp--yhakpfhLNLLTHSETRYQLFRELYEAHP-ELqIGGPSHRWVWQSLMATKQCLQLTRQI 259 Vibrio cholerae

Q250S9       212 QLPCLILHGTGDRLVPYQAS----QRI--FAEI---SSR--DKTLKLYEGLYHELIHEPE 260 Desulfitobacterium hafniense Y51
Q6CZI2       274 TTPLLLLQAEEERVVDNRSQnvfcQTL--TQSG---DANs-NGVLQVIHGARHEILFETD 327 Pectobacterium atrosepticum
P07000       259 ATPTLLLQAEEERVVDNRMHdrfcELR--TAAG---HPVe-GGRPLVIKGAYHEILFEKD 312 Escherichia coli K-12
P44800       249 EIPILILQAEKEKIVDNKNL----EKL--TALF---P----NARCEVILNAKHEVLFEKD 295 Haemophilus influenzae Rd KW20
Q47VY9       262 KTPILLLQASGDTVVCQQAQddfcQQL--HTLQ---PQScpNGVPSNIDNAFHELFFETD 316 Colwellia psychrerythraea 34H
Q6LVU9       261 ATPILLIQGSDDNIVDNQAHhrfcQAM--NQAN---R----SCELKTINGARHELLFEKD 311 Photobacterium profundum
Q5QYM1       266 TISVILFQAGNDKVVSASGQ----KKV--AAAV---TRD--HFRFETIKGASHELMMETD 314 Idiomarina loihiensis
Q8E8D2       258 RTPILILQAGEDKIVDNAAQ-----------NL---AVSs-NCQLKVIAGAAHEIFMEKD 302 Shewanella oneidensis
WP_023283109 259 TAPTLLLQAEEERVVDNLMH----DRYceLRAAaghPCE--GGKPLVIEGAYHEILFEKD 312 Klebsiella pneumoniae
WP_001067680 260 KIPMLILQAGEEAIVCNRAQirlfKKL--SRTQ---K----RAALCRIAGARHELLFEQD 310 Vibrio cholerae
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