4KM9


Conserved Protein Domain Family
SUFU_C
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pfam12470: SUFU_C (this model, PSSM-Id:289253 is obsolete and has been replaced by 463598)
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Suppressor of Fused Gli/Ci N terminal binding domain
This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologues. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologues.
Links
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Statistics
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PSSM-Id: 289253
Aligned: 16 rows
Threshold Bit Score: 238.842
Created: 27-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4KM9_A       258 ERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDdedsrsicIGT------Q-------------PRRLSGK----DTEQIR 314 human
Q7PYI0       249 RQLELDLEKEGSDLAGVNADFTFKELAKGALT--------VAV------Kkevld---pdedlSRSISSCniavKEEANE 311 Anopheles gambi...
XP_975412    242 EEVERGFELEGSNLSGVSARCSWVEQD------------------------------------PARIDIMhlkeKSDCDN 285 red flour beetle
XP_002429835 242 EIIEKGIETEGSNLGGVSAKCSWIEKDFDIECslheqssiIAK------Sel----------gGPRISEq----ESQQIK 301 human body louse
XP_008187827 253 DEITEGIKTEGSNLCGISAHCSWEELNNRCDKalaynsveHSM------N-------------NLRIINNsrapNED--- 310 pea aphid
XP_001601038 275 EKVQSGIAREGSNLSGVSAKCWWVQMGDKSTQkyreqrqeSDE------EddgelepeeeidiKPNIKSErlspCEQDVK 348 jewel wasp
XP_001842898 243 RQLEIDLEKEGSDLAGVNADFTFKELPKIAIKkeiv--dpeeE------I-------------TKSISSCnieiKKEFND 301 southern house ...
EFX89751     267 REVEHGIDRDGCSLSGVSARCHWEERKVTSKTgsa--------------------------wrsPEAEDDsssqDDEEDE 320 common water flea
XP_002013953 249 INLQDDLEKQGSDLAGINADFTFKETKP-TIVkqevdfqsLSErcateeN-------------NRPMTESqmkrEEPSFP 314 Drosophila pers...
ETN62340     248 RQLELDLEKEGSDLAGVNADFTFKELAKGALTpttattttTSI------Kqevld---peeelSRSISSCniavKQESGD 318 Anopheles darlingi

4KM9_A       315 E-TLRR---------GLEINSKPV---------------LP------------Pinpqrqnglahdrapsrkdslesdss 357 human
Q7PYI0       312 K-DTLEqstgstssdMVNPFDNPN---------------IP------------S-------------------------- 337 Anopheles gambi...
XP_975412    286 F-QAQEd---------VTLLNSPQ---------------KPlqsgnfeqnrssStnfkmd-------------------- 320 red flour beetle
XP_002429835 302 S-ELKKgll----ssKPGINNSLIktedfedfdryvlffLP------------Nvsvrksdimfq--------------g 350 human body louse
XP_008187827 311 ----LKet------dG-------------------------------------Nsnyksc-------------------- 323 pea aphid
XP_001601038 349 M-SVEQds------nGL--------------------------------------------------------------- 358 jewel wasp
XP_001842898 302 GlEHSGss------dMVNPFHHSQ---------------VP------------S-------------------------- 322 southern house ...
EFX89751     321 P-EAGAtlgrhrpadGEPTINGEI---------------WP------------I-------------------------- 346 common water flea
XP_002013953 315 Q-SMSLssnslhkscPLDF--QPQ---------------AP------------D-------------------------- 338 Drosophila pers...
ETN62340     319 D-SLERsggs--ssdMVNPFDNPT---------------IP------------S-------------------------- 342 Anopheles darlingi

4KM9_A       358 taiipheliRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSitGDMAITFVSTGVEGAFATEEHPYAAHGPWLQ 437 human
Q7PYI0       338 ---------RVFPLTGIELTLAPYAAKFLMLAVRDRIRHGRHFTFKA--QHMAVTFVAESVTGSIVNRQTPYAVLGSWVQ 406 Anopheles gambi...
XP_975412    321 ---estellHIKKLEGVHLVFNLEAGSLLPLAIRGRVRHGRHFTFKSvlGETAITLVAGTVTGTLVNSEHPYVAQGSWLQ 397 red flour beetle
XP_002429835 351 nfaestelvHVVHLEGIHLTFNLESGILLPLALRGRVKHGRHFTFKSvlGDTAITFVASSVTGTFVNSDHPYAAHGPWLQ 430 human body louse
XP_008187827 324 ---elselnQGQFIENVHITFNLEAGLLLPFVLKGRIRHGRHFTFKAltGDATITFVASAVSGSLVSEEKPFVAQGSWLQ 400 pea aphid
XP_001601038 359 -----------KTLMGLHLTFNLEAGTLLPLAIKGRVMHGRHFTFKSilSHAAVTLVPPSVTGTFATKEKPYAVQDPWLQ 427 jewel wasp
XP_001842898 323 ---------RVSPLNGIELTLAPYAAKFLVLAIKDRIRHGRHFTFKA--QNMAVTFVSESVTGSIVTKDSPYGVLGYWVQ 391 southern house ...
EFX89751     347 ----------RRLYKGVHLTLNLEAASLLPVVLRGRLRHDRHFTFKAvaGETAVTLLTSRVGGALASPSAPLVAKGPWLQ 416 common water flea
XP_002013953 339 ----------CISLDGIEITLAPTVAKYLLLAIKDRIRHGRHFTFKA--QHLALTLVAETVTGAAVSVHEPYGVLGYWIQ 406 Drosophila pers...
ETN62340     343 ---------RAFPLTGLELTLAPYAAKFLILAMRDRIRHGRHFTFKA--QSMAVTFVAESVTGSIVNXXX---------Q 402 Anopheles darlingi

4KM9_A       438 ILLTEEFVEKMLEDLEDL--T--SPEEFKLPKEYSWPEKKLKVSI 478 human
Q7PYI0       407 ILIPNRLVPRMVERFGELs-Tr-SADGLKIPLTYEWPEQNLKFII 449 Anopheles gambiae str. PEST
XP_975412    398 ILITDDLAQDMAVTFQVL--A--TPEALSLPKTFSWPDKKLSVTI 438 red flour beetle
XP_002429835 431 VLIPDDFATEMITDIEMLn-Q--NTDEITFPKTFAWPDRKIVITI 472 human body louse
XP_008187827 401 VLVSNSFLDSMESSLKFL--N--EPVMEPLPKTVNWPDRNLTITI 441 pea aphid
XP_001601038 428 VLLPDELTERMAQEFQVL--N--APEQLQLPKTFTWPEYKLAITI 468 jewel wasp
XP_001842898 392 ILIPNALIPKMIDTFSDL--Ns-SVDNLKIPLTYEWPEHNLKFII 433 southern house mosquito
EFX89751     417 ILVDSEWLAKLESDLACL--Q--QPDGVVVPKTFCWFDRQMALTV 457 common water flea
XP_002013953 407 VLIPNDLVPRMMDDFRNA--NldENTELTQRLQFDWPDKNLRLIL 449 Drosophila persimilis
ETN62340     403 ILIPNRLVPRMVECLSELgtK--SAESLNIPLSYEWPEHNLKFII 445 Anopheles darlingi
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