Conserved Protein Domain Family
MT
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pfam12777: MT (this model, PSSM-Id:289543 is obsolete and has been replaced by 463699)
Microtubule-binding stalk of dynein motor
the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Links
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Statistics
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PSSM-Id: 289543
Aligned: 3 rows
Threshold Bit Score: 691.386
Created: 21-Apr-2021
Updated: 29-Sep-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9UFH2       3043 ERLENGLMKLQSTASQVDDLKAKLAIQEAELKQKNESADQLIQVVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQKAC 3122 human
Q9NYC9       3067 ERLENGLLKLHSTSAQVDDLKAKLAAQEVELKQKNEDADKLIQVVGVETDKVSREKAMADEEEQKVAVIMLEVKQKQKDC 3146 human
XP_011680580 3028 ERLENGLTKLQSTAQQVDDLKAKLASQEVELAQKNEDADKLIQVVGVETEKVSKEKAIADDEEKKVAIINDEVSKKAKDC 3107 purple sea ur...

Q9UFH2       3123 ETDLAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSLK 3202 human
Q9NYC9       3147 EEDLAKAEPALTAAQAALNTLNKTNLTELKSFGSPPLAVSNVSAAVMVLMAPRGRVPKDRSWKAAKVTMAKVDGFLDSLI 3226 human
XP_011680580 3108 TEDLAKAEPALLAAQEALNTLNKTNITELKSFGSPPPAVLKVAAAVMVLLAPNGKVPKDRSWKAAKIVMNKVDAFLDALI 3187 purple sea ur...

Q9UFH2       3203 KFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRI 3282 human
Q9NYC9       3227 NFNKENIHENCLKAIRPYLQDPEFNPEFVATKSYAAAGLCSWVINIVRFYEVFCDVEPKRQALNKATADLTAAQEKLAAI 3306 human
XP_011680580 3188 NYDKENIHENCQKAIKEYLNDPEFEPEFIKGKSLAAGGLCSWVVNIVKFYNVYCDVEPKRIALQKANDELKAAQDKLVII 3267 purple sea ur...

Q9UFH2       3283 KNKIAELNANLSNLTSAFEKATAEKIKCQQEADATNRVILLANRLVGGLASENIRWAESVENFRSQGVTLCGDVLLISAF 3362 human
Q9NYC9       3307 KAKIAHLNENLAKLTARFEKATADKLKCQQEAEVTAVTISLANRLVGGLASENVRWADAVQNFKQQERTLCGDILLITAF 3386 human
XP_011680580 3268 KAKIAELDANLAELTASFEKATSDKLKCQQEAESTSRTITLANRLVGGLASENVRWGEAVANFKIQEKTLPGDVLLITAF 3347 purple sea ur...

Q9UFH2       3363 VSYVGYFTKKYRNELMEKFWIPYI 3386 human
Q9NYC9       3387 ISYLGFFTKKYRQSLLDRTWRPYL 3410 human
XP_011680580 3348 VSYIGCFTKNYRLDLQDRMWLPFL 3371 purple sea urchin
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