Conserved Protein Domain Family
CENP-L
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pfam13092: CENP-L (this model, PSSM-Id:289837 is obsolete and has been replaced by 432969)
Kinetochore complex Sim4 subunit Fta1
CENP-L is one of the components that assembles onto the CENP-A-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENP-A-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta1 is the equivalent component of the fission yeast Sim4 complex. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals.
Links
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Statistics
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PSSM-Id: 289837
Aligned: 80 rows
Threshold Bit Score: 89.9559
Created: 22-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q0UQA1       138 GFTSLPLLLVKMPGPVREIFLNYLRTAFDAHVAPLRLPSSFITSSLETYFKHLSAststqsiqDVVRQLHIQLAF--PTT 215 Phaeosphaeria n...
EKC32305     112 HFTYYPVLLVKSTVAMTDVLITWLMRHFDCKISPLVFPPVYMAWMIAMWSGALa--------nTNRKNKPVELVYqvPSE 183 Pacific oyster
XP_001631557   9 HFVSLPVCLAKGTVALTRYVLSWLERQFDCRITPMVFSPSELSWYSSLWAGTVPKe----------sEHLLELCYkvPTG 78  starlet sea ane...
XP_002607643 198 aFTVLPLLLMTGPGTLQNAVGSWLEQRFDCRVCPMTFQPSDLLWAMALGLIrg--------tnDKVKKQTLDLHYnvPLK 269 Florida lancelet
XP_002122642 178 klTMLPLLVCRGDRSTTKVVFDWLKTEFDCSLRKITFNPLSLGWLVAMWGSVKGQg-------------sTHITWeiPMV 244 vase tunicate
EFX84777     160 GVVHLPVLLARGPRAVREKVHDCLSAVFSSSIHEVSFPAEDMHWMIAAWSGFIN---------ESRNNKEVSFMYgiPS- 229 common water flea
XP_012055679 152 NSIRLPLLLCRGTRSCMDAVHTIIGRMFDCLIVTLPANEDDLCWLVPIIITATNe-------dKPIIFGEVQMEYtvP-E 223 Atta cephalotes
XP_006571456 155 sSIRLPLLLCRSTQGTMGIVHTILSRMFDCMIVTLSAHEDDLLWLIPIVIIPITKe------eQPKSKDEIHMEYkiP-E 227 honey bee
XP_011169215 153 NSIRLPLLLCRGTHSCMNAVHDIIGRMFDCLVVALPVNEDDLSWLLPIIIIasd------kddQPIVDGEVQMEYivP-E 225 red fire ant
XP_004363698 259 DFTFLPLLLVKSTPQLTQEVCGWLESTFDCKVTHLAFPPVELAWMAFMWSAQ-NVsyt--aaaAAAAAAAAAAAAaaNES 335 Capsaspora owcz...

Q0UQA1       216 TTLLKHIDMTIAGTDVPGFVARGK---------A------L----KGGADKPFTTALSHYL-----------KAHLALDM 265 Phaeosphaeria n...
EKC32305     184 CEGIKKITYTIEAADCLRVWNSIHdsk----sdM------F----TEEEMTTFISSLEDHF-----------YSLFRVKL 238 Pacific oyster
XP_001631557  79 IRGLRQITLSVNASDARELWECMHpsd----sdI------F----NEEESVFFMHSLESHF-----------YHHFKISL 133 starlet sea ane...
XP_002607643 270 EAGLSKISLQIPVKHAKALLSSVTedt----enD------L----QLDELHLFRQALEAHM-----------FHYFRIHL 324 Florida lancelet
XP_002122642 245 ETGIDIIESEIDGESVALLWKHAHeds----tmE------V----TIDEVRGFVASIEEHL-----------TQHTKILF 299 vase tunicate
EFX84777     230 --RTDTIQCQYSVNFIKDLWSCIHdkd----npV------V----ELSEVKRFYSSLIKHT-----------KNTIGLNL 282 common water flea
XP_012055679 224 LPITDIIKVKYHSSDLKEILSAIVgdr----ndR------VnvflDYEHMEMFHKVLHEQM-----------LMAGDLQL 282 Atta cephalotes
XP_006571456 228 LPDTDTITIKFKILDLIKILTVIIkdq----ndEaslemtF----NLEHIEKFREVLYSQI-----------LELAGLQL 288 honey bee
XP_011169215 226 LPVTDTITVKFHTLDLRKILSVIVedqdnrvnvS------L----DHKHIELFHEVLHKQMltlgglqlglcMLH-RINL 294 red fire ant
XP_004363698 336 SPALCD---ALNRSKAAQ--REAGdas----smF------L----AVDTSQAFMKALEEHF-----------FSISGIRL 385 Capsaspora owcz...

Q0UQA1       266 SHAKAHISRITCNSFHLGT-ERLKLT 290 Phaeosphaeria nodorum SN15
EKC32305     239 N--AMQLSCVGTSLCYIGRdGILKV- 261 Pacific oyster
XP_001631557 134 G--SMSLSRIANSLVFIGGeGRLKIL 157 starlet sea anemone
XP_002607643 325 DT--MKLCLVATPVLFVDKnGRLKIL 348 Florida lancelet
XP_002122642 300 N--ALTMQQIKTPVIQVRNdGKFKVT 323 vase tunicate
EFX84777     283 --AAVPLIMYKTPDFELHTvGKVKVS 306 common water flea
XP_012055679 283 G--LCTLRRINLPGITIMe-NRMKVT 305 Atta cephalotes
XP_006571456 289 G--LCALHKIHLPTLTIMe-NKMKVM 311 honey bee
XP_011169215 295 RGVTIRe-------------NRMKVM 307 red fire ant
XP_004363698 386 S--ALQLTRIGTGTAYVGAeGRVKLF 409 Capsaspora owczarzaki ATCC 30864
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