Conserved Protein Domain Family
Nudc_N
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pfam14050: Nudc_N (this model, PSSM-Id:290757 is obsolete and has been replaced by 464073)
N-terminal conserved domain of Nudc.
The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics. NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger.
Links
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Statistics
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PSSM-Id: 290757
Aligned: 38 rows
Threshold Bit Score: 62.5508
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q8IAW7         5 KHENMLMAIAR-DFNSVDDLIETFLTFLENKTDYFHVML-N-------D-K---DvetlsekydgailknllnnnNCGFK 71  Plasmodium falc...
Q4XGV9         5 KHENMLMHIAR-DFRSIDDLVEVFLSFLENKTDYFHLMM-N-------D-D---DiqtlskkydgniakailnnnTCGFK 71  Plasmodium chab...
XP_002908770   4 RFDALLAQMAQ-QHGGVEPLLESFFGFLHRKTDFYVVSS-D-------PaK---A--------------------KMGFL 51  Phytophthora in...
KFH15931      14 MHEELLLNLAR-HHPDIESLLQTFFDFLERRTDFFHVIE-SsgasaglE-S---P--------------------NMGFR 67  Toxoplasma gond...
XP_001617186   5 KHENMLLAIAR-DFQSIDNLIETFFSFLEHKTDYFHVML-N-------E-D---DigtlakkyegtlekdilnnnKCGFK 71  Plasmodium viva...
EJK73183      18 aFEQPLMAMANlSKGDLRKLFYALFSFLNRRTDFYCIHDkS-------D-G---P--------------------NMGFV 66  Thalassiosira o...
CBN79652       7 KFDDVLRNLAG-QAGSLEALLGAFFSFLHRNTDFYVTFD-P-------T-KtarA--------------------GMGFP 56  Ectocarpus sili...
XP_002286618  22 HFEAPLIALANlSGGDLRKLFYAFFSFLNRRTDFYCILP-D-------D-G---Sgas---------------grNMGFK 74  Thalassiosira p...
CBY42989       5 RFDGQFLHMAQyTDGGVRGLVDVFFSFLRRKTDFYTGSD-E-------D---------------------------LNES 49  Oikopleura dioica
XP_002181567  39 GTDALLISLANrCGGDLRQLLFVFFSFLNRRTDFYLVPH-E-------D-D---Qkeg---------------kaRMGFQ 91  Phaeodactylum t...

Q8IAW7        72 AHSREQLLIKSFR 84  Plasmodium falciparum 3D7
Q4XGV9        72 ANSREIELMKSFR 84  Plasmodium chabaudi
XP_002908770  52 PGQAQQKVLaafq 64  Phytophthora infestans T30-4
KFH15931      68 EGRAEAMVRQAFs 80  Toxoplasma gondii MAS
XP_001617186  72 AHSREQNLMKSFR 84  Plasmodium vivax Sal-1
EJK73183      67 EGQAEKILLASFR 79  Thalassiosira oceanica
CBN79652      57 AGKAEKLLLRAFR 69  Ectocarpus siliculosus
XP_002286618  75 EGQAEQILIASFR 87  Thalassiosira pseudonana CCMP1335
CBY42989      50 RKIAKELVDERFQ 62  Oikopleura dioica
XP_002181567  92 EGDAEKVLLASFR 104 Phaeodactylum tricornutum CCAP 1055/1
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