Conserved Protein Domain Family
CFTR_R

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pfam14396: CFTR_R (this model, PSSM-Id:291094 is obsolete and has been replaced by 316884)
Cystic fibrosis TM conductance regulator (CFTR), regulator domain
Statistics
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PSSM-Id: 291094
View PSSM: pfam14396
Aligned: 15 rows
Threshold Bit Score: 333.607
Threshold Setting Gi: 123912793
Created: 15-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q1LX78        638 DFSSLLLGLEAYDNISAERRCSILTETLHRVSVDESAGMQ---PERSAFRQVpp----------tkPMYIDERKASvIVN 704  zebrafish
Q07DZ6        639 DFSSKLMGYDSFDQFSAERRNSILTETLRRFSLDGDAAGSwneTKKQSFKQT--------------GEFGERRKNS-ILN 703  platypus
ABB89815      639 DFSSKLMGYDSFDQFSAERRSSILTETLRRFSIEGDTAVSwneGKKQSFKQT--------------GDFGERRKNS-ILS 703  gray short-ta...
XP_004046152  605 DFSSKLMGCDSFDQFSAERRNSILTETLRRFSLEGDAPVSwteTKKQSFKQT--------------GEFGEKRKNS-ILN 669  western lowla...
XP_008109380  639 NFSSELMGFDAFDHFSADRRNSILTETLRRLSIDSDGMGSrneMKKPSFKQT--------------SDFTEKRKNSv-MN 703  green anole
CAG08756      580 DFSSLLLGLEAYDNINAERRSSILTETLRRVSVDETASFRgpePIRQSFRQPpppvipgsqghpggDGYPEKRKQSlILS 659  spotted green...
XP_003449218  640 DFSSLLLGLEAYDNINAERRGSILTETLRRVSVDETASFRgpePIRQSFRHApaqs------hplgDGYPEKRKQSlILN 713  Nile tilapia
XP_012815406  626 EFSSHLTG---FDHFNAERRNSIITETLRRCSIDSDPTAVrneVKNKSFKQV--------------ADFSEKRKNSvI-N 687  western clawe...
XP_006505042  639 DFSSKLMGYDTFDQFTEERRSSILTETLRRFSVD-DSSAPwskP-KQSFRQT--------------GEVGEKRKNS-ILN 701  house mouse
XP_007256023  637 DFSSLLLGLEAYDNVNAERRCSILTETLRRISVDESSGIR---PDRSSYRQVa------------pPAYKDERKSSvIIS 701  Mexican tetra
Q1LX78        705 PLGVARKASFIQVP----------EEEVRRTL--PDRKFSLVPENELVDESFMGSDVYH-NHgVHMAGQ-RRQSVLAFMT 770  zebrafish
Q07DZ6        704 PLNSIRKFSLVQKAplq----mncIDETLDEP--PERKLSLVPDSEPGEAILPRSNMLN-PG-PVLRAR-RRQSVLNLMT 774  platypus
ABB89815      704 SLNSIRKFSVVQKSqpq----mngIEENDDEP--LERRLSLVPDSEQGEAILPRSNIMN-TG-PTFQGRnRRQSVLNLMT 775  gray short-ta...
XP_004046152  670 PINSIRKFSIVQKTplq----mngIEEDSDEP--LERRLSLVPDSEQGEAILPRISVIS-TG-PTLQAR-RRQSVLNLMT 740  western lowla...
XP_008109380  704 ALNSSRKFSLIQKTplq----angIEESIGEP--VERRLSLVPDSEQGEAILPRSNVLN-PG-PTFRGP-RRQSVLNLMT 774  green anole
CAG08756      660 PLAAARKFSFMGNSnagnatqsmaPEEGVHEL--SERRFSVVPEDDQVEEVLPRSNVYH-HGlHHLSGQ-RRQSVLAFIT 735  spotted green...
XP_003449218  714 PLAAARKFSFIGNSqqtg---nttVEDRSDEL--PERRFSVVPEDEQIEEALPRSNLYH-DEfQHLSGQ-RRQSVLEFIT 786  Nile tilapia
XP_012815406  688 PRKSSRKFSIMQKSqpq----msgIEEEDIPPnqGERKLSLVPESEQGEASLPRSNVLN-TG-PTFQGR-RRQSVLNLMT 760  western clawe...
XP_006505042  702 SFSSVRKISIVQKTplc----idgESDDLQ-----EKRLSLVPDSEQGEAALPRSNMIA-TG-PTFPGR-RRQSVLDLMT 769  house mouse
XP_007256023  702 PLMADRKSSFTPTGl---------EEEVRRPL--SDRRISLVPENELVDDCFMGNDTYHnHG-VHLAGQ-RRQSVLAFMT 768  Mexican tetra
Q1LX78        771 N---AQGQGRREHLQSSFRrR-LSVVPQSELaSELDIYTRRLS-DSTYDMTGILEEENIEACLTDEideIE-ETFETTKW 844  zebrafish
Q07DZ6        775 RpsiHQGSSLYKKGSASAR-K-MSVAPQSNM-SEMDIYSRRLSkDSGLEISEEINEEDLKECFIDD---IE-STTSVTTW 847  platypus
ABB89815      776 RpsvCQGQNMYKTGNAA-R-K-MSMAPQSKL-SEIDIYSRRLSqDSGMDISDEINEEDLKEWFFDD---VE-NIPAVTTW 847  gray short-ta...
XP_004046152  741 Hs-vNQGQNIHRKTTASTR-K-VSLAPQANL-TELDIYSRRLSqETGLEISEEINEEDLKECFFDD---ME-SIPAVTTW 812  western lowla...
XP_008109380  775 RtsvHPGQSFYTKNSVSVR-K-MSVVHQa---SEIDIYARRLSrDSVVEITEELNEEDLKECFFDD---TE-TMNTVTTW 845  green anole
CAG08756      736 T---SQGQERREQIQSSFR-KkLSVTPQCDLaSELDIYARRLSkDSVYDISEDVDEEDMEQCFADD---RE-NTFETTSW 807  spotted green...
XP_003449218  787 S---ARGQERREQMQSSFRkK-LSITPQYNLpSDLDIYSRRLSkDSVYDISEDVDEEDMEQCFADE---RDkNVFETTSW 859  Nile tilapia
XP_012815406  761 RtsvSQGSNAFATRNTSVR-K-MSVGSFSNSsFEVDIYNRRLSqDSILEVSEEINEEDLKECFLDD---TD-SPSPTTTW 834  western clawe...
XP_006505042  770 Ft-pNSGSSNLQRTRTSIR-K-ISLVPQISL-NEVDVYSRRLSqDSTLNITEEINEEDLKECFLDD---VI-KIPPVTTW 841  house mouse
XP_007256023  769 N---AQGQGRRDQLQSSFR-RrLSIVPQSELaSEVDIYARRLSkDSMYDITGDLDEENIEACLADEq--IE-NVFETTKW 841  Mexican tetra
Q1LX78        845 NTY 847  zebrafish
Q07DZ6        848 NTY 850  platypus
ABB89815      848 NTY 850  gray short-tailed opossum
XP_004046152  813 NTY 815  western lowland gorilla
XP_008109380  846 NTY 848  green anole
CAG08756      808 STY 810  spotted green pufferfish
XP_003449218  860 NTY 862  Nile tilapia
XP_012815406  835 NTY 837  western clawed frog
XP_006505042  842 NTY 844  house mouse
XP_007256023  842 NTY 844  Mexican tetra
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