Conserved Protein Domain Family
EphA2_TM
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pfam14575: EphA2_TM (this model, PSSM-Id:291255 is obsolete and has been replaced by 464211)
Ephrin type-A receptor 2 transmembrane domain
Epha2_TM represents the left-handed dimer transmembrane domain of of EphA2 receptor. This domain oligomerizes and is important for the active signalling process.
Links
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Statistics
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PSSM-Id: 291255
Aligned: 127 rows
Threshold Bit Score: 36.2403
Created: 24-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O61460        562 IIIALILIVIAVAlCMIVVQkksknrkqmsdldvldtykqdsmtpdyhttsrhhhhqgnlpatlheqlrsttklnaplip 641  Caenorhabditi...
ELK10483      202 VAVGVVFLLVLVG-IGFFIHrrrkslrtrqsse----------------------------------------------- 233  black flying fox
XP_012401075  491 ILGGLILLLALAL-AGLFVHrrrrnlrarqsse----------------------------------------------- 522  Tasmanian devil
XP_007253452  553 IAGGGVMLLIVVV--ILLLHkrrlnshvrqrsg----------------------------------------------- 583  Mexican tetra
XP_007246310  549 AVGGGVMLFIVVV--VLLLHkrrknshtrqgpe----------------------------------------------- 579  Mexican tetra
XP_006642063  546 AIGGIAMLLIVAI--VLLLRrrrrnpharqgpe----------------------------------------------- 576  spotted gar
XP_005459908  552 AVLVAMMLIVVSA--VLFFRrrkrnshtrqgpe----------------------------------------------- 582  Nile tilapia
CAG06982      582 VFGIMVILLVAVA--VLLLRrrkinfwhrggpedpyfpagdksapvr----------------------------prgfq 631  spotted green...
XP_003448439  541 VFGVAVILLVVVA--GLLLRkrrlnarrrggp------------------------------------------------ 570  Nile tilapia
XP_005816658  516 VVGVAVILLIVVA--VLLLRrrslcsrgrggp------------------------------------------------ 545  southern plat...

O61460        642 sfgspisqpppyyggvhpnsgkYKTYVDPTTYEDPYQALIEFTFDI 687  Caenorhabditis elegans
ELK10483      234 ----------dvyfskseqlkpLKTYVDPHTYEDPNQAVLKFTTEI 269  black flying fox
XP_012401075  523 ----------dvyfskseqlkpLKTYVDPHTYEDPNQAVLKFTTEI 558  Tasmanian devil
XP_007253452  584 ----------gnyfacpeklqpLKTYVDPHTYEDPCTAILKFASEI 619  Mexican tetra
XP_007246310  580 ----------dayfsspeqlkpLKTYVDPHTYEDPNTAVMKFASEI 615  Mexican tetra
XP_006642063  577 ----------dtyfsspeqlkpLKTYVDPHTYEDPNQAVLKFTTEI 612  spotted gar
XP_005459908  583 ----------dtyfstpeqlkpLKTYVDPHTYEDPNVAVLKFATEI 618  Nile tilapia
CAG06982      632 vkgvrndstlgclccssdqlkpLKSYVDPHMYEDPNIAIQKFVTEI 677  spotted green pufferfish
XP_003448439  571 ----------edpyfssdqhkpLKMYIDPHTYEDPNIAIHKFVTEI 606  Nile tilapia
XP_005816658  546 ----------edpyfstdqlkpLKAYVDPHTYEDPNIAIQKFVKEI 581  southern platyfish
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