Conserved Protein Domain Family
TMEM192
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pfam14802: TMEM192 (this model, PSSM-Id:291468 is obsolete and has been replaced by 434223)
TMEM192 family
The function of this family of transmembrane proteins is unknown. In vertebrates, proteins in this family are located in the lysosomal membrane and late endosome. In Arabidopsis, a member of this family has been found to weakly interact with FRIGIDA, a determinant of flowering time.
Links
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Statistics
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PSSM-Id: 291468
Aligned: 30 rows
Threshold Bit Score: 212.5
Created: 28-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5EAL6        27 APLLPSQKLQSVIRPh--FHPVPTICISILLALVNLAYVTLAVVAIYFCLFSE-KEKKCkqsidpfqLSTVLVISKLVLW 103 western clawed ...
Q7QBM9        14 SKLYSPPCLMEGKPR---FRPIFVISLFSAHLFLAIAIITAGTVASVAGWPQPaGDTDRss-----sVYFLIIYLRIVYW 85  Anopheles gambi...
Q16JL1        44 HHTMFGTTIGDIETVg--FERIGTTHASWIQLIFSMILTMTGFIFAYHGCYSGnECP----------GYYMVLYLRALFW 111 yellow fever mo...
XP_011251461   3 EEQSFQPILSSQEEDn--FQQLNTVPIVSMSLLLGISLEITGIVFVSVWPEEQnKCD----------TYFIYLYLHCAYW 70  Florida carpent...
XP_001844360   2 edgqLDPILATEDDDg--FRPLKTVPAFSFHLLISTCISLTGVILAATWQDS---CRCE--------AYFIMLYMRAAFW 68  southern house ...
XP_971408     26 DPEHLQPILESY--Gt--FRPLNTVPVFSLHLLFTLALEIVAIVFAVQHPDEKyKC--R--------EYFIIIYIHAGLW 91  red flour beetle
ETN61777      26 tlgsqePILATQENGd--FEPFYTAPVFSFHLLISSIISVTGIALAATWDDTR-RCE----------AYFIMMYLRVAFW 92  Anopheles darlingi
XP_002103035  23 TDQLLDPVLFSNDNGs--YK-LNTVPAFSLHLVISTAISIVGIVLAASFPTDR-RCD----------AYFIMLYLRATFW 88  Drosophila simu...
XP_001990723  21 TDELLDPVLVSDNNGp--YK-LKTVPAFSIHLLISTVISSVGIGLAVGFPADR-RCE----------AYFIMLYLRATFW 86  Drosophila grim...
XP_312774     33 nQSLFHSTSNTEPEDsvrFDKLETVPSACIQLFVTLTLTIISVIYTLQQCDTTtVCV----------YYYMLLYLRGVYW 102 Anopheles gambi...

Q5EAL6       104 LLHVVNERFAQHHHCKARSRGFlHLYRSTRHLKALPLIIHSTGNAALLLILSVQDSFTSNSQ-------------LYPCL 170 western clawed ...
Q7QBM9        86 LVTYVIHERNKAEFVRLAEPDF-DHYRALAVYRKAPLQIATLWNVILLTVQNQVRYLFPYERpdhgaggalnpaiTPQVF 164 Anopheles gambi...
Q16JL1       112 LATYVIHLYMKSKHNRLKLLGYhKFLRITHRQKKAPLQLVSLSNLLILTIHTIILELYGTNFindcy----vkglSLTLF 187 yellow fever mo...
XP_011251461  71 LIVMVTDHVVKARHHKLRIDGYlDFYQITYRLIRIPLFITSLWNTCYLLLAVILHHTHKIDYeryck---tsewfTPLNY 147 Florida carpent...
XP_001844360  69 LITFLIDHYVKRHHEKLRLDGYhDFHRATTGHRAVPLQIVSLWNTFLLAVQALIQHYYGDSFaekcv---vvgflSPIVY 145 southern house ...
XP_971408     92 FLTLIVDQIARRKHYNLRILGYlEFYNKTHIHHRLPLYVVSLWNAVIMIIQAIAQQFYPDNFaekci---nggtmSPIGY 168 red flour beetle
ETN61777      93 IITYLVDYLVKKHHRALAMKGYlDFNRATKHHSTVPLQIVSLWNTFLLAIHTLMQHYYGEDFgtkci---vlgwlSPIVY 169 Anopheles darlingi
XP_002103035  89 VITYLFDHFVKKQHDNLRMQGYhDFHRETNMQKGIPLQLVSLWNSMLLAVQALIHHYYAENFwehca----agwlSPVSY 164 Drosophila simu...
XP_001990723  87 VITFLLDKFTKKQHDDLRLNGYhDFHRETKKQTDVPLQVVSLWNSALLAVQAAIHHYYGDGFgthca----egwlSPITY 162 Drosophila grim...
XP_312774    103 AIVYLIHLYTKSRHQSLNRCGHhTFAARVHRHKKSSLQLVTLSNMVLLTVHTAMGHGFGETFmqrcf----vegfSSVVF 178 Anopheles gambi...

Q5EAL6       171 ILSVLLLELILSVICLIIYTvriyrfnksKPRPDIIEEEKINAFHG-----HVN--PEIGfr-hSASLEEVVEKQGDTIE 242 western clawed ...
Q7QBM9       165 VVVVCALELLVLLCFYVPLV---------RILIDIRRGEGHGKVTDlryrrMTD--TELA----EQPIEWQLERQAVLIK 229 Anopheles gambi...
Q16JL1       188 LSIWCLVECMILTYIHVTYFvkvrvfntmRSPPDALTSAEIRRNAHh-----------------RVSAEELINQQFLMIV 250 yellow fever mo...
XP_011251461 148 IFVLTNLELVIIVPAYINYIkrvmrfnqlRPLPDVTRDEWLSSFTQd----SYSgmGEIGyherGTNMEELLEKQADLIR 223 Florida carpent...
XP_001844360 146 ITMFCSLETFVLALVNGSYIgkvvrfnrtAAPPDALQG------SRg----HSS--GSLGltqrGLSTTELLEKQADLIN 213 southern house ...
XP_971408    169 LCALITFEFCLIAGININYIfkvqrfnkqKAPPDVQREEWNASMS------PEA--TEIGsplrGEKLYDFLQKQADLIR 240 red flour beetle
ETN61777     170 ITAFSCLETGVLSIVNGSYIakvrrfnrtAAPPDALQDNRGMR----------G--GSVGltqrGLSTTELLEKQADLIN 237 Anopheles darlingi
XP_002103035 165 VTAFTVAENLVLAVSHSLYIdkvrkfnsaKLAPDVLRGAd-----------RAG--GSLGlmqpGGDTEELLEKQADLIA 231 Drosophila simu...
XP_001990723 163 VTVFNVAENLVLTASHSFYInkvrkfnkaKLSPDVLRGDN-----------RAT--GSLGlmqpGGDTAELLEKQADLIA 229 Drosophila grim...
XP_312774    179 VASFTLLETMVIVPVQLSYIvhvrvfnltRPMPDAQHSANDLSLRLcp-teDYS--VNDSfk-sIADPKEFVQLQAALIS 254 Anopheles gambi...

Q5EAL6       243 YLKHHNALLSKQLLA 257 western clawed frog
Q7QBM9       230 RLRAERDRLQREAKL 244 Anopheles gambiae str. PEST
Q16JL1       251 KMMDDNRHLQDKIRE 265 yellow fever mosquito
XP_011251461 224 YLRDHNINLSHRIML 238 Florida carpenter ant
XP_001844360 214 YLKDHNLKLNQKIMQ 228 southern house mosquito
XP_971408    241 FLKEHNAKLGEKLMV 255 red flour beetle
ETN61777     238 YLKDHNLKLNQKIMQ 252 Anopheles darlingi
XP_002103035 232 YLRDHTHKLNQKLHQ 246 Drosophila simulans
XP_001990723 230 YLRDHTHKLNQKLHQ 244 Drosophila grimshawi
XP_312774    255 KLKEENDQLHSRIQE 269 Anopheles gambiae str. PEST
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