Conserved Protein Domain Family
NAD_binding_11
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pfam14833: NAD_binding_11 (this model, PSSM-Id:291499 is obsolete and has been replaced by 434252)
NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidized to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.
Links
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Statistics
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PSSM-Id: 291499
Aligned: 85 rows
Threshold Bit Score: 85.6381
Created: 24-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9K9L1       166 GSGTVVKLANNMVIGVHQAVLGECYLFVEKAGVDPAIAYEIIKRSAGFS---KS---M----EWS------V-DAILDRA 228 Bacillus halodu...
Q1GHN2       156 GAGQAAKICNNMILGVTMIATCEAFALADKLGLDRQKMFDVVSTSSGYSwtmNAycpA----PGV------GpQSPADND 225 Ruegeria sp. TM...
Q0APF3       163 GSGQAAKICNNMLLAITMIGTCEAFALAEKLGLDAQNFYDISSKASGQS---WS---M----TSYcpvpgpIpTTPANNG 232 Maricaulis mari...
WP_012448581 164 GAGDTLKLVNNLMLGANMLIASEAMALGTKAGLDPDVLFEVISESSGRS---YA---L----EAK------YpKFISQGN 227 Natranaerobius ...
WP_013386576 164 GAGDTVKLINNMLLGINMVACAEAMALGTKAGIKPDLLYEIISQSSGSS---YA---L----KAK------YeNFISQGN 227 Ilyobacter poly...
WP_014189336 165 gagqaaKICNNMILGISMIGVCEAFVLAEKLGLSHQALFDVSSTSSGQC---WS---L----TSYcpvpgpVpASPANRD 234 Azospirillum li...
WP_011795697 167 GAGQTAKICNNMLLGILMAGTSEALALGAANGLDPAVLSEIMRRSSGGN---WA---L----EKYnpwpgvMpQAPASKD 236 Acidovorax citr...
WP_015842879 165 GSGATAKLAHNTIVGINMAALAEGMAIAASGGINGSAFLELVQ-SGGAA---SR---T----AEL------KgEKVLASD 227 Paenibacillus s...
GAN52253     169 GAGQLTKTINNVLYDINIAALAEVLPMAVAMGLDPDQVAQVVTTGTSRS---YA---A----QYF------Vp-RILRGQ 231 Methylobacteriu...
WP_013652656 165 GTGQAAKICNNMILGISMIAVSEAFVLAERLGLDAQKLFDISSTASGQC---WSl-tTycpvPGP------VpSSPANRD 234 Polymorphum gilvum

Q9K9L1       229 FDPRFSINLLHKDIGLALKLGEQLGIPLEMVEKGEERV-RAAKEQYGHE-DVSAIIRPL 285 Bacillus halodurans
Q1GHN2       226 YQPGFAADLMLKDLRLSQQAAGSADADTPMGKLAEALYsQFVDKEDGKGkDFSAMLPRF 284 Ruegeria sp. TM1040
Q0APF3       233 YKPGFATAMMLKDLKLAQDAAQSAGATTPLGAQAEALY-AMFDNLGGGSsDFSGIYKLL 290 Maricaulis maris MCS10
WP_012448581 228 FDPGFSIDLEYKDLELAISTAKDMNMPLIMGNLTQQLY-EAARCEGLGDrDISAMINMY 285 Natranaerobius thermophilus
WP_013386576 228 FEPGFMIDLQYKDLQLAISTAKELNAPMFMGNIAQQMF-ETARAEGLGKkDISAVINLY 285 Ilyobacter polytropus
WP_014189336 235 YQPGFAAALMLKDLKLAQEAAQSAGAPTPLGAAAAQLY-ALMNAQGEGGtDFSGIIRML 292 Azospirillum lipoferum
WP_011795697 237 YAGGFGTDLMLKDLGLAQENAAAVKAATPLGGLARSLY-AAHSLAGHCElDFSSIVRLV 294 Acidovorax citrulli
WP_015842879 228 YDVQFSLALMLKDLRLSSVLSDGLKVPTPMLEAAKSLF-QIGDSMGLGElDMSSVTQAY 285 Paenibacillus sp. JDR-2
GAN52253     232 FDEGYPMGAAYKDLVAAAAVAAENGFPMPVTAAATATY-QTALRQGHGDrDKGAMVLPF 289 Methylobacterium sp. ME121
WP_013652656 235 YQPGFAAQMMLKDLKLAQEAAQSSGASTPLGAQASTLY-NLFCNAGNADvDFSGIVRFL 292 Polymorphum gilvum
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