Conserved Protein Domain Family
CECR6_TMEM121
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pfam14997: CECR6_TMEM121 (this model, PSSM-Id:291658 is obsolete and has been replaced by 464432)
CECR6/TMEM121 family
This family includes Cat eye syndrome critical region protein 6, a protein which has been identified in a screen for candidate genes for the developmental disorder Cat Eye Syndrome (CES). It also includes the TMEM121 transmembrane proteins. The function of this family is unknown.
Links
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Statistics
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PSSM-Id: 291658
Aligned: 17 rows
Threshold Bit Score: 174.374
Created: 24-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q7RFR8        59 AFSAIkggtCWLLYVYSIAIKVIFMYFFAFSDndileNTRT-----DY-YNKSIVFILLSLSTLIYTALSVKSYKQLYPD 132 Plasmodium yoel...
Q99MX7       308 AFAYL----AWLIYSIAFTPKVVLILGTSILD-----LIEL-----RApFGTTGFRLTMALSVPLLYSLVRAISEAGAPP 373 house mouse
Q1L877        74 GYAMI----LWFFYVFVLEIKVYFVYQNYKAEg----D-RA-----DA-LTCKALTVLLSVFIPGLYVTLAAIDHMEYVR 138 zebrafish
XP_419324    200 GYAMI----LWFLYVFVLEIKVYFVYQNYKADr-----KSL-----DL-MARKALTLLLSICIPALYVLLVATEHMEYVR 264 chicken
XP_003089128 189 KYACF----AWGVYALVLIFKIGTCFRLFYEDipptpLDNN-----DKlFDDFLFKAGLSLSV-LIFLFIFESHHYTPLV 258 Caenorhabditis ...
NP_001138269  73 GYAMI----LWFLYIFVLEIKLYFVFQNCKADr-----KSL-----ET-VARKALTLLLSICVPGLYLVLVALDSMEYVR 137 zebrafish
XP_003379508  76 KYAFI----CWISYSLALIIKICIIFRLVVSh-----LSKA-----EV-FGPSVLELTLTFS-ALVFLLLVFSHHFNDPR 139 Trichinella spi...
XP_005164731 167 TFAYL----AWLIYVIASTPKVVLVLETSILDl----IALK-----VP-FGVTGFKITMLLCAPLLYCLINSIIED--PN 230 zebrafish
EFO21083     164 KYTWI----GWLLYSVVLAGKVAVCFRLFYTQl----PPTKtdlhdKI-LDDHLFRLGLSLSAP-IFILLLESHHYTTVS 233 eye worm
XP_005173099  74 GYAMI----LWFLYIFVLEIKVYFIYQNYKADr-----KSL-----DA-LARKALTLLLSVCVPLLFLVLVAVDHMQYVT 138 zebrafish

Q7RFR8       133 Ent----isNEKIFHKDLILHVVIDLFDIFELLFTLLRLPhiiestNF--WIKIIGGVLISFSV-YLngySFPIISIVAE 205 Plasmodium yoel...
Q99MX7       374 GsagplllqPQQHRAAGCFLGTCLDLLDSFTLVELMLDGRv-----PL--PAHLRYLLIAVYFL-TL---ASPVLWLYEL 442 house mouse
Q1L877       139 Pl-------KKREELRSRLFWVVVDLLDILDIQASLWEPQr----kGL--PLWVEGLTFFYCYI-LLl--ILPCVSLSEI 202 zebrafish
XP_419324    265 Tf-------KKKEDLRNRLFWVIVDVLDVLDIQANLWEPQk----kGL--PLWAEGIMFFYCYIlLL---VLPCVSLCEI 328 chicken
XP_003089128 259 S--------VRQVYISYLVAAICLDLIDNIYFLDLLWQASkd--kwNL--ELWLEWTILVVACI-NF---FMPTFALAKL 322 Caenorhabditis ...
NP_001138269 138 Tf-------RRKEDMRGRLFWVALDLLDLLDMQANLWEPQr----tGL--PIWAEGLMFFYCYIlLL---ILPCVSLSEI 201 zebrafish
XP_003379508 140 S--------RRQAYISYLASSVTLDIIDSVVFLKFLLDPRih---eDVynSLTLQVVILVLACF-NF---ILPTFALSKL 204 Trichinella spi...
XP_005164731 231 G--------ATRFHSQGCFVSTCLDILDSFILVEVLLKNEi--------pNVYLRYTVISVYFI-AL---GVPVVWLYEL 290 zebrafish
EFO21083     234 S--------NRQLYLIYLMTTITFDLIDTICFLDLLWQSSkn--nwNL--PFWLDITILLLACV-NL---ILPVFTLLRL 297 eye worm
XP_005173099 139 Af-------RKKEEIRNRLFWVVVDLLDVLDIQANLWEPQk----kGL--PLWAEGLMFFYCYIlLL---VLPCVCLSEI 202 zebrafish

Q7RFR8       206 KNSKN----LDLGDIYFCK-K-H-S-AVIGIILIDIPFMILRFylLVF-------YFSNIHFQPLLIKNICFIPIKCITI 270 Plasmodium yoel...
Q99MX7       443 NTATAapswGQTSGPGSCS-R-L-L-RLLGGCLVDVPLLALRS--LLV-------VSYQQPLSIFMLKNLFFLGCRGLEA 509 house mouse
Q1L877       203 SMQGV--------NIVPHK-M-LlY-PILSLVAINFITILIRGgnMVF-------YRDIRVSGILMGKNVLAIVLKTCSF 264 zebrafish
XP_419324    329 SMQGI----G----IMPHRmM-L-Y-PMLSMLTVNITTIFIRGsnMLF-------FRDSRVSSIFMGKNMLAIGLKVCMF 390 chicken
XP_003089128 323 RYAKV-----PRFL-LVSE-K-L-W-AFLYVLLVNGPFLGLRI--YLYivlevqqHGKKYDPSLFGVKNIAMIYIALREL 390 Caenorhabditis ...
NP_001138269 202 SVQGD--------HISPQKmM-L-Y-PLLSLVTINIVTILIRGvnMVL-------FQDSRVSTIFVGKNVVAIATKACTF 263 zebrafish
XP_003379508 205 RFNIE----LPRWLPLPYE-Q-L-Y-SLLYFLTVNLPYLVIRA--HLWas----nTNSMSDGTIFIVKNVIMIMVGIREM 270 Trichinella spi...
XP_005164731 291 TASEM-----------NCR-W-V-WaRFFTGVLLNAPLLVVRC--FLV-------FVYKTPVSVFMFKNIFFLGCKCLEL 347 zebrafish
EFO21083     298 RFGRR----LPRFA-LVSE-K-I-W-SLIYVLMVNAPYLGIRI--YLYvllemstHGKHYDASILMIKNIAMIYLAVRDV 366 eye worm
XP_005173099 203 SMQGI--------NISPQK-MlL-Y-PILSLASINVVTLFIRGgnMLL-------YRDGRVSGILMAKNMLAIVLKTCSF 264 zebrafish

Q7RFR8       271 KR 272 Plasmodium yoelii yoelii
Q99MX7       510 LE 511 house mouse
Q1L877       265 VQ 266 zebrafish
XP_419324    391 VQ 392 chicken
XP_003089128 391 WT 392 Caenorhabditis remanei
NP_001138269 264 LE 265 zebrafish
XP_003379508 271 Wi 272 Trichinella spiralis
XP_005164731 348 VE 349 zebrafish
EFO21083     367 WT 368 eye worm
XP_005173099 265 VQ 266 zebrafish
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