Conserved Protein Domain Family
DUF4592
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pfam15262: DUF4592 (this model, PSSM-Id:291915 is obsolete and has been replaced by 464602)
Domain of unknown function (DUF4592)
This protein family is a domain of unknown function, which lies to the N-terminus of the protein. This domain family is found in eukaryotes, and is typically between 114 and 130 amino acids in length. There are two completely conserved residues (L and A) that may be functionally important. In humans, the gene that encodes this protein lies in the position, chromosome 2 open reading frame 55.
Links
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Statistics
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PSSM-Id: 291915
Aligned: 24 rows
Threshold Bit Score: 63.2754
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
Download Cn3D
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005037638  144 PTMKLGPPPPFgLHAKRTDDAGTSS-EDDGLPRSPPEMSLLHESLIS-GMRTRFSDSHKHLSSLSLAGTGSEEEEQitLG 221  collared flyc...
XP_005045368  115 KNIKFGQPPQMtVSARTMGEANASA-EDDALLSSPMETETQQDTVIS-DCSNKSTDTPDFLRKMNFLGPGHEMEEK---- 188  collared flyc...
XP_008510994   45 KNIKFGQPPPKaVPMKKADSGEASL-EEDLFLTSPMEIVTQQDIVLS-DTENKSSATPSSLSPLNLPGARSEMEEK---- 118  Equus przewal...
XP_010708422   45 KNIKFGQPPQMtISGRTMGEANASV-EEDMFLGSLMEIDSQQDTVLS-ESGNKSADTPDLLRPMNLPGTG-QMEEK---- 117  turkey
XP_008266057   45 KNIKFGQRPANaLPVRKADGGEASL-EEGPLLPRPMETQTPWDVVLS-DTENKAGHTPGSPGAVNPPGGGSDMEEK---- 118  rabbit
XP_005666754  107 KNIKFGQHPPSaIPMKKADSGEPRF-EEHPFLTCPVESVPEQALVLV-DTESKPSETPGTPSPLNLPAARSEMEEK---- 180  pig
XP_005479282  128 QGIKFGQRPP---SLRRSEGDEGSS-DEEEVPRSPLKVLAQVEAEPL-RTEPK-------------------QVQG--GQ 181  Nile tilapia
XP_002934718   45 gNIHFGLRPDS-IPRKRMQGLGASTgEMDTSHISPMEIGGEQDKGPQqKAATMVTGSPSSFSSMNNIELEHKTEEK---- 119  western clawe...
XP_011612907   77 QGIKFGQRPP---SLRKSEEDEGST-DEDEAPQSPLKVLAQVEPEPS-NTESK--------------VYGTQQVE----- 132  torafugu
XP_005319568  212 prqpsISPPLI-RSGTISKDLEEMS-GDDELPMNPQMKASSHKILAA-KKNYSEATTGTGLSQSSTACASSNVTQQ---- 284  thirteen-line...

XP_005037638  222 SSSRSRSTDgqlftrhgstSTESP--RTSTDSTISPTaNFDTPPELSAFLDNSAAKHKLLIKPRNQRFSR 289  collared flycatcher
XP_005045368  189 -----VTPV----------KSARPkrQFSCSGTIETI-NLDSVPQALARLDNSAAKHKLSVKPKKQRMSR 242  collared flycatcher
XP_008510994  119 -----VVPV----------KPSRPkrHFSSAGTIESV-NLDAIPLAIARLDNSAAKHKLAVKPKNQRVSK 172  Equus przewalskii
XP_010708422  118 -----VTPV----------KSSRPkrQFSCSGTIETI-NLDAVPQAVVRLDNSAAKHKLSVKPKKQRMSR 171  turkey
XP_008266057  119 -----VAPV----------KPSRPkrHFSSAGTIESV-NLDAIPLAIARLDNSAAKHKLAVKPKNQRVSK 172  rabbit
XP_005666754  181 -----AAPV----------KPSRPkrLFSSAGTIESV-NLDAIPLAIARLDNSAAKHKLSVKPKNQRVSR 234  pig
XP_005479282  182 PFGPHSPPV----------KSPRSkrVLPLTGTIESI-NLDAVPQSVPRLDNAAAKHKLSVKPKNQRVSR 240  Nile tilapia
XP_002934718  120 -----VTPV----------KPSRSkrPFAVSGTIESI-NLDAVPRSVDRLDNTFAKHKLSVKPKNQRVSK 173  western clawed frog
XP_011612907  133 ---PHSTPV----------KSPRTkcALPPTGTIESI-NLDALPQSAPRLDNAAAKHKLSVKPKNQRISR 188  torafugu
XP_005319568  285 -----------------------------------PV-GFSIPATTQGCLDSSAARHKMALNPRKQKKKK 318  thirteen-lined ground s...
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