Conserved Protein Domain Family
NYAP_N
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pfam15439: NYAP_N (this model, PSSM-Id:292079 is obsolete and has been replaced by 464717)
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
NYAP_N is an N-terminal family of eukaryotic proteins that are substrates of tyrosine kinase in the brain. When first identified, the family members were referred to as unconventional myosin XVI, or Myr 8. However, proteins have now been identified as being integrally involved in neuronal function and morphogenesis. The family is involved in both the activation of phosphoinositide 3-kinase (PI3K) and the recruitment of the downstream effector WAVE complex to the close vicinity of PI3K; it also appears to regulate the brain size and neurite outgrowth in mice.
Links
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Statistics
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PSSM-Id: 292079
Aligned: 32 rows
Threshold Bit Score: 241.913
Created: 17-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9Y6X6       1231 NMQEEGSKRTD---D--------KS-----------------------GPRHFHPSSMSVCAAVDGLG------Q----- 1265 human
XP_007233584   58 RRQDEAIKR--------------MGedvgsm-----------adggayAGKHFRMGFMTMPAPLDRLPp-----P----- 102  Mexican tetra
XP_003197868   52 RKQEEAIKRGE---Evv------------------------------tEGKHLRMGSMSMPAPAEHMSphqhqhP----- 93   zebrafish
XP_003975643   52 RKKEEAIKRTged--------------------------------iatEGKHLRIGSITMPEPQERMPi-----Plpqal 94   torafugu
XP_006249205   15 HKEEEAKRSSS---K--------EAaptgpvgsgavpgpgvrvrdiasLRRSLRMGFMTMPASQEHTPh-----P----- 73   Norway rat
XP_011485098  105 RKQEEAIRRTgen--------------------------------vaaEGKHLRMASITMPDPPERLPm-----Shlhai 147  Japanese medaka
XP_003768872   15 HKEEEAKRSTS---KevgpagpsGPgpgvra------------rdvssLRRSLRMGFMTMPASQEHVPh-----P----- 69   Tasmanian devil
XP_011609959   76 qRDQDGSKKSSsqnD--------PSatvgkv------------rdlasFRRHFRMGFMTMPASQDLSPh-----S----- 125  torafugu
XP_006802244   54 qRDQEGSKKSStqnD--------PSatvgkv------------rdlasFRRHFRMGFMTMPASQDLSPh-----S----- 103  Neolamprologu...
XP_005472084   54 qRDQEGSKKSStqnD--------PSatvgkv------------rdlasFRRHFRMGFMTMPASQDLSPh-----S----- 103  Nile tilapia

Q9Y6X6       1266 -CLVGPSIWSPSLHSVFSM-------D--------DS--------SS------LP----------SP-----------RK 1294 human
XP_007233584  103 -SGPGFTVRSQSLHSVGGG-------E--------EE--------GGg-----SP----------TL-----------RK 132  Mexican tetra
XP_003197868   94 -CNPGFSVRSQSLHSVGGL-------E--------EE---------G------SP----------TS-----------RK 121  zebrafish
XP_003975643   95 aCGQAFSVRSQSLHSVGGGgnsggggD--------EE--------VG------SP----------TS-----------RK 131  torafugu
XP_006249205   74 -CRSAMAPRSLSCHSVGSM-------D--------SV--------GG------GPgggggglledSS-----------TR 112  Norway rat
XP_011485098  148 aCGQGFSVRSQSLHSVGGG-------N--------NG--------GGgeeevgSP----------TS-----------RK 183  Japanese medaka
XP_003768872   70 -CRSAMAPRSLSCHSVGSM-------E--------SS--------GS------TT----------GGggssgvggdvgAR 109  Tasmanian devil
XP_011609959  126 -CASAMAPRSQSCHAVGAG-------DpdlengdySD--------TQ------SQ----------HG-----------GR 162  torafugu
XP_006802244  104 -CASAMAPRSQSCHAVGAG-------D--------TSlengdysdTQ------SQ----------HG-----------GR 140  Neolamprologu...
XP_005472084  104 -CASAMAPRSQSCHAVGAG-------D--------TSlengdysdTQ------SQ----------HG-----------GR 140  Nile tilapia

Q9Y6X6       1295 QPPPKPKRDPNTRLSASYEavsa---------clsaAr-EAA-------------NEALARPRPHSDDYStmKKIPPRKP 1351 human
XP_007233584  133 QPPPKPKRDPNTKLSTSSEtvna---------tlstGkgGKEt-----------dKSDASKSRPCSEEY---RRMPPPKP 189  Mexican tetra
XP_003197868  122 QPPPKPRRDPSTKLSISSEavdi---------sptyCkgDESe-----------rCDGTQ----GCSEDC--RKVPPPKP 175  zebrafish
XP_003975643  132 QPPPKPRRDPATKLSMSSEavdhs--------pmstCrgDRCd-------------------aQGCSEDC--RRVPPPKP 182  torafugu
XP_006249205  113 RPPAKPRRHPSTKLSMAGP-----------------GaeTPPs-----------rKAGSQKPTPECRESS--RKVPPQKP 162  Norway rat
XP_011485098  184 QPPPKPRRDPATKLSMSSDavdhs--------piytCygEKCd-----------aAQG-------CSEDC--RRVPPPKP 235  Japanese medaka
XP_003768872  110 RPPVKPRRHPSTKLSMAa-----------------sGaeLPPs-----------kKAGSQKPGPEGRESS--RKIPPQKP 159  Tasmanian devil
XP_011609959  163 CPPAKPKRHPSTRLSSSSAeg--------------rGltEIPplpsgysqskhseKKNAMKKSESGEIGS--KKVPPLKP 226  torafugu
XP_006802244  141 CPPVKPKRHPSTRLSSSSAdsrgpppetppppplthSqaKHSe-----------kKNA-MKKSDSGEIGT--KKVPPLKP 206  Neolamprologu...
XP_005472084  141 CPPAKPKRHPSTRLSSSSAdsrg---------pppeTppPPPpthsq---akhseKKNAMKKSDSGEIGT--KKVPPLKP 206  Nile tilapia

Q9Y6X6       1352 KRSPNTKLSGSYEEIS---------GSRPgdarpAGAPGAA----A-----------RVLTPGTPQCAlppaappGDEDD 1407 human
XP_007233584  190 KRNPNTQLSTSFDESY----------IRNhgtkfKSASLPRrqkkK-----------SASQNQSPALD-------TDEEA 241  Mexican tetra
XP_003197868  176 KRNPNTQLSTSFDESY----------IRSngskgSTTMLF-----S-----------RDGQTPSPQPQ-------DLD-- 220  zebrafish
XP_003975643  183 KRNPNTQLSVSFDESYikshgsgaiCPSKhlhrvVSPSELN----A-----------SPQSDESPTD--------DCED- 238  torafugu
XP_006249205  163 RRSPNTQLSVSFDESC---------APAPsprggNLPLQRL----S-----------RASRIAGDLDA-------GAQEE 211  Norway rat
XP_011485098  236 KRNPNTQLSVSFDESY----------IKShgnsgVCMSKPL----NyttspcernhlHSQSDESPSN--------DCDD- 292  Japanese medaka
XP_003768872  160 KRSPNTQLSVSFDESC---------SMAPtsrvgALPLQRH----S-----------RGGRGVGEHDL-------SSQDE 208  Tasmanian devil
XP_011609959  227 KRSPSTQL--SFDP------------PATrvppsAASLPFQ------------------AADSQIQTG-------DSED- 266  torafugu
XP_006802244  207 KRSPSTQL--SFDP------------LPPrvppsATSMPFQ------------------ASDSQIQTG-------DGDD- 246  Neolamprologu...
XP_005472084  207 KRSPSTQL--SFDP------------LPPrvppsATSMPFQ------------------ASDSQIQTG-------DGDD- 246  Nile tilapia

Q9Y6X6       1408 sEPVYIEMLG-HAA-----------------------------RPDSPDPGESVYEEMKCCLPDDGGp---------G-- 1446 human
XP_007233584  242 -EPVYIEMVG-NILrdfnq-------------------itgghADEEDNQDESVYEEMKYPMYDEVAp---------P-- 289  Mexican tetra
XP_003197868  221 -EPVYIEMSG-NVGqea------------------------tpRTEEDEPGEAVYEEMKYPALDEYDs---------R-- 263  zebrafish
XP_003975643  239 -EPVYIEMGGiDVGsre------------------------plKSEDEEPGESVYEEMKYPALDDMEy---------R-- 282  torafugu
XP_006249205  212 -EPVYIEMVG-DVFrgggrsgggltgp----plgsggptppaaADSDSEDSEAIYEEMKYPLPEETGdgrangppplM-- 283  Norway rat
XP_011485098  293 -EPVYIEMGGiDVGsre------------------------alKSEDEEPGESVYEEMKYPVLDDMEy---------R-- 336  Japanese medaka
XP_003768872  209 -EPVYIEMVG-DVFqggggssgrssggpagasvggggtgpptgPDSDSEESEAIYEEMKYPLPEDVAe---------Gra 277  Tasmanian devil
XP_011609959  267 -EPVYIEMVG-QVFtresqtatp-----------hpvtpvattPDSDSDQSEAIYEEMKYPMQEDRDp------------ 321  torafugu
XP_006802244  247 -EPVYIEMVG-QVFtrdsqtatp-----------hpvtpvattPDSDSDQSEAIYEEMKYPMQEDREs---------H-- 302  Neolamprologu...
XP_005472084  247 -EPVYIEMVG-QVFtrdsqtatp-----------hpvtpvattPDSDSDQSEAIYEEMKYPMQEDREs---------H-- 302  Nile tilapia

Q9Y6X6       1447 ---AgSFLLHGASPpLLHRAPE-----------------------------------------DeaagPPGDACDIP--- 1479 human
XP_007233584  290 ---A-DQAQSRWEP-CPTSAVPdveltr------------------------------pstprGs-------LCDIP--- 324  Mexican tetra
XP_003197868  264 ---W-DLVNCRS----LCVTPCpsesei------------------------------ytplsRcttpRGVPLCDIP--- 302  zebrafish
XP_003975643  283 ---T-D-------P-VGCRSACptpapy-----------------------------dpeplsRcstpRNIPLCDIP--- 318  torafugu
XP_006249205  284 ---A-PSPPQQPHV-LQPHPHPhrrpas------------------------------alpsrRdgtpTKTTPCEIP--- 325  Norway rat
XP_011485098  337 ---T-D-------P-VGCRSACptpapy-----------------------------dpeplsRcstpRNIPLCDIP--- 372  Japanese medaka
XP_003768872  278 ngaP-PTAAVSPLH-HTHSHHShrrpas------------------------------alqsrQngasTKISPCEIP--- 322  Tasmanian devil
XP_011609959  322 -----------------HTPRAptpyl--------------------------------lqgnKseseS---NTKIP--- 346  torafugu
XP_006802244  303 ---R--HLPSKHEK-LKTSKHFhvtpssassssslprpsssspsyskpkatvsishssplpasAsstpVPQVLSASPhtp 376  Neolamprologu...
XP_005472084  303 ---R--HLPSKHEK-LKTSKHFhvtpssassssslprpsssspsyskpkatvsishssplpasAsstpVPQVLSASPhtp 376  Nile tilapia

Q9Y6X6       1480 -PPFPNLLP---------------------HRPPLLVFPPTpvtcspaSDESPLTPLEVKKLPVLet------------- 1524 human
XP_007233584  325 -APFPNLLT---------------------HRPPLLVFPPApaqcspnSDESPLTPLDVTKLPMIen------------- 369  Mexican tetra
XP_003197868  303 -APFPNLLS---------------------HRPPLLVFPPApaqcspnSDESPLTPLDVAKLPMFen------------- 347  zebrafish
XP_003975643  319 -APFPNLLT---------------------HRPPLLVFPPApaqcspnSDESPLTPLDVTKLPMLen------------- 363  torafugu
XP_006249205  326 -PPFPNLLQ---------------------HRPPLLAFPQA-------KSASRAPGDGVSRLPVL--------------- 361  Norway rat
XP_011485098  373 -APFPNLLT---------------------HRPPLLVFPPApaqcspnSDESPLTPLDVNKLPMLdn------------- 417  Japanese medaka
XP_003768872  323 -PPFPNLLQ---------------------HRPPLLAFPQA-------KPTTRTPGDGVSRLPVL--------------- 358  Tasmanian devil
XP_011609959  347 -APFPNLLQ---------------------HRPPLLAFPQP---------AAASSGVGVQNKAst--------------- 380  torafugu
XP_006802244  377 rAPTPYLLQgnkseqesntkipapfpnllqHRPPLLAFPQP---------AAASSGVGVQNKSSAstkmgtqtssattqa 447  Neolamprologu...
XP_005472084  377 rAPTPYLLQgnkseqesntkipapfpnllqHRPPLLAFPQP---------AAASSGVGVQNKSSAstkmgtqtssattqa 447  Nile tilapia

Q9Y6X6       1525 ------nlKYPVQPEGS-----------------------S--Pls----------pQYSKSQ---------KGD----G 1550 human
XP_007233584  370 -------vGYVK--PGS-----------------------S--PtagdpgqpvpeqpKPSGHHhhhhhhhhkKSS----D 411  Mexican tetra
XP_003197868  348 -------gSFGKSPTSS-----------------------SlePsg----------sASTSHM---------RR-----A 373  zebrafish
XP_003975643  364 -------qSYSKSPTSS-----------------------Ae--------------pPPSAHL---------R------- 383  torafugu
XP_006249205  362 --------CHSKESAGS-----------------------T--Pa-----------pQVPARE---------RETpplpP 388  Norway rat
XP_011485098  418 -------qSLSKSPTSSn----------------------E--Pts----------sAHIR------------------- 437  Japanese medaka
XP_003768872  359 --------CHTKESAVP-----------------------V--Pa-----------lQVPGRD---------QETt--pT 383  Tasmanian devil
XP_011609959  381 -------sSKMGTQTSSvttqasassstssssnatasgskE--Ssg----------gSATQQD---------KHS----R 428  torafugu
XP_006802244  448 stsssassNIPVSLSGS-----------------------K--Ess----------gGSAAQQd--------KHS----R 480  Neolamprologu...
XP_005472084  448 stsssassNIPVSLSGS-----------------------K--Ess----------gGSAAQQd--------KHS----R 480  Nile tilapia

Q9Y6X6       1551 DRPASPGLALFNGS--GRASPPStPP 1574 human
XP_007233584  412 SKEGSSTHTITVSG--RSSAPPL-PS 434  Mexican tetra
XP_003197868  374 ERELTATPTITASG--RSSAPPL-PC 396  zebrafish
XP_003975643  384 -RELTATPTLTVSG--RSSAPPL-PC 405  torafugu
XP_006249205  389 PPPAANLLLLGPSGraRSHSTPL-PP 413  Norway rat
XP_011485098  438 -RELTSTPTLTVSG--RSSAPPL-PC 459  Japanese medaka
XP_003768872  384 PPPAANLLLLGPSGraRSHSTPL-PP 408  Tasmanian devil
XP_011609959  429 DSQLCPAPGLRA----RSHSTPL-PP 449  torafugu
XP_006802244  481 DAQLGPAPGLRA----RSHSTPL-PP 501  Neolamprologus brichardi
XP_005472084  481 D----SQLGPAPGLraRSHSTPL-PP 501  Nile tilapia
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