Conserved Protein Domain Family
SPICE

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pfam15678: SPICE (this model, PSSM-Id:292306 is obsolete and has been replaced by 464796)
Centriole duplication and mitotic chromosome congression
SPICE is a family of proteins found in chordates. It localizes to spindle microtubules in mitosis and to centrioles throughout the cell cycle. Deletion of SPICE compromises the architecture of spindles, the integrity of the spindle pole and the process of aligning chromosomes on the spindle (chromosome congression).
Statistics
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PSSM-Id: 292306
Aligned: 19 rows
Threshold Bit Score: 217.655
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5RKG1        33 NTVNDLTVHRATPEDLVRRHEMHKSKNRALVHWELQEKALKRKW-------KKQKPETSS-IEKRKLSIMKEILSDQYQT 104  Norway rat
XP_008118675  33 STIHDLSVLRATPEDIAIRHEMHKSKNRALAHLELQEKSLENTR-------NKLRPRAPQsVEKKKLDLMRAIISDQYQL 105  green anole
XP_012425407  30 STVHDLTVHRATPEDILRRREIHKSKNKALAHVELQEKALNRKW-------KKQRQVDADsLEKRKLALMREILSDQHHW 102  zebra finch
XP_006000127  21 NTVSELSVHRATPEEIVQRHEMHKSKNRSLAQWELRERALRKKL-------RKQGQGSPDiLEKRKLAIMREVLFDQYQM 93   coelacanth
NP_001121472  34 STVSDLTVLRATNEELEHRREIHRSKNQWLARWELQNKATNKKS-------EKENGGFSAlLENSRLALMKEILSDQYLM 106  western clawed...
XP_011487240  33 STVHDLSVHKPTPAELTHRHEIHKSRNKAVAQWELKEKALKRCA-------R--QAGSPApLDPASLSIIREVFSDQLLL 103  Japanese medaka
XP_005797961  33 STVNDLSVHKLSPAELCHRHEIHKSHNKAAAHWELREKALKRRL-------R--HAGSSPgLDHTSLTIIRDVFSEQPLL 103  southern platy...
XP_005162750  32 STVNDLSVHKATPEELARRHEMHRSQNRVVAQWELKEKTLTRRR-------RKNQPLSPPgLDRARRDIIREVFSDHCQL 104  zebrafish
XP_002606849  34 DTTSDLSVHKATDEEIKHRHEVHQSKNLDVIRLENQKMMIQKDScfnyiciARARPKTPStVEKRKAALLREVLYDHS-- 111  Florida lancelet
XP_001640231  45 STVNDLNVYKASEDEVRQRHEAHKSKNYGLPRKQATNK-----E-------NSPGYITTPnSAQRKQAILQEILYGRDQF 112  starlet sea an...
Q5RKG1       105 QDVLEKSDHLLTAAKGLFvdvpRKRTgfpnv----tmapgS--SRSPAGINQDPGTQ-SILNESIIEPQALNEvddggae 177  Norway rat
XP_008118675 106 HDVLEGSDQAMAVVKDLFgdapHWHLgfpnvtvapdhdveS--SEDLIVQKCDLPTQlSILSESVMDPQALNEkeecsf- 182  green anole
XP_012425407 103 QDVLERSGQVIAVAKDLLeaapRTRTgfpnvtmapncdleS--SQGPIVQKSHPPSQlSILSESVMDSQalheee----- 175  zebra finch
XP_006000127  94 QDVLERSDRAMAVVKDLFgdapHRHAgfpnvtmapdsemdT--SVGPIAQKRDSLTQlSILSESVMDSQALNEdvens-- 169  coelacanth
NP_001121472 107 NDVLERSDRALAVVKDLFgdapRRHTgfpsvtmapscdldT--SRAPIVQKKDPPTQlSILSESIMDSQAINEvdks--- 181  western clawed...
XP_011487240 104 QDVLARSDRAMAVVKDLFgdapQRQIghpsvtmapncdsdT--EL-PVLERPDPPTHlSFLSQSMMDQEALNDlev---- 176  Japanese medaka
XP_005797961 104 HDALAQSDRALAVVKDLFgdapRRQTghpsvtvapncdsdS--EL-PVLQRPDPPTQlSLLSQSIMDQEALNEvev---- 176  southern platy...
XP_005162750 105 QDVIARSDRALAVVKDLFgdapRRRTgfpsitvapdcdsdS--EL-PVHQKLDPPTQlSLLSQSMMDQQALNEleehe-- 179  zebrafish
XP_002606849 112 QDVLSKSDRVMAVVRDLFgddpKRYTgfpnvt--kapdnpS--GRGPVIEPPEQPTQlSMLSQSIMDQSALNEvdae--- 184  Florida lancelet
XP_001640231 113 QDVLAESDRTMSVVKDLFgddpKKYMgfpnitvppqvlseNteRNGPIAEVPEAQTQlTQLSESVMQTAALNEisedeg- 191  starlet sea an...
Q5RKG1       178 stahsqsEDS--ESELPNSL--SPHSNRNTERflhqlkeenselinqlwtdiqqkiaaqsqrtppgsp------------ 241  Norway rat
XP_008118675 183 -vcntnsEGG-------VYL--NTRSNIDTKRvlnllkednsvancqpeaskqhistvsteevdill------------- 239  green anole
XP_012425407 176 --eealaEDG--HHDV---L--GFKSRINSDRllrllrkgnslvnsplwvekdmrkstlsqesnvpct------------ 234  zebra finch
XP_006000127 170 --qsecsEDG--EEEVDASM--NFKSSVDMNRfrcllnekdnsfsqsrtkppplagnlpktpktpvrps----------- 232  coelacanth
NP_001121472 182 ---lspaEYS--DSEAEVTI--STQPNRKAERgqqllsgegpkneafitpcksggdpsqt-------------------- 234  western clawed...
XP_011487240 177 -----skENR--RVE-------NTSSDSHVIHrvtgrksksqsgsgvlrqqkmhhsnfhhadsddgpv------------ 230  Japanese medaka
XP_005797961 177 -----srEDV---RDEDLSS--SSGSR--FIRrtnirktktqtratqkqkghrlrshagdkenipvt------------- 231  southern platy...
XP_005162750 180 ---------eecdeVQDASV--HLKSVMH--Rkrnkcrpksfprgsdnheqdlpqkpcttg------------------- 227  zebrafish
XP_002606849 185 ---reqgEAG--E-EQTLSQ--QFESRLDLQRfrrfleqerqqdstlrqqdstlrqqdstlstipgeqqgqqgaatstml 256  Florida lancelet
XP_001640231 192 --nssgtEPSpqSNQNQAAQrmTFQPRLDLQKfkefvsqeqndsgqpsyevknpisasrsqgiprgkvlq---------- 259  starlet sea an...
Q5RKG1       242 -sselsaedqkgalnatdavkriqaglqpeesaepvdSSY-VGQVl--NTRKPKPLLSKVKRKQDMRALSKQKKNMLSSS 317  Norway rat
XP_008118675 240 --tpaasfqslehtalnathvvkkvhsrfqneeqtadTPCtIQQVlnaKVKKQKHTSTKVKKKQTAQTPTGQTRINLNAT 317  green anole
XP_012425407 235 -pttvspsldhsalnatsvikrthsrlrnedeeesvdSSDtVRQVlnpNSRKQKQIAAKMKRKQAEQNSARQKR---GDS 310  zebra finch
XP_006000127 233 taepssalnattvvrrvksrlgmgdgasaalnglspeNTLvVGQVlnpGPGKKKRTAAKGKKSRRADAPSAKERECYQPS 312  coelacanth
NP_001121472 235 ----------hcalnattavnrvkvrrteeespkpeeSESiIGRVlnpQGKANKRISSKGKKTRSATPSHTKDLSACRES 304  western clawed...
XP_011487240 231 ---tpcasrkppnqnalnatvavqrvrskhfeeneeetSSqVSQVlnpEPLLCRS-GRSGSCTRKVRKCVSHGSELDGST 306  Japanese medaka
XP_005797961 232 --pirsgrapdptalnataavkrfltkqrpsdqneeeASVlVSQVlnpELPSRQS-GRIRKHTEKTRKGVCRALELDGSS 308  southern platy...
XP_005162750 228 ---------vredyaalnatvaveqlksrqthpgvnqSTSfVDQFlnpEPASSQH-GVKNRSVQASRGRSAHTSAMNSSG 297  zebrafish
XP_002606849 257 qagtshqvessnpvrtvnmsqvqptavntqtpvrdvdSTSlTNQAindTAKVTRTRSRAGAADHT--------------- 321  Florida lancelet
XP_001640231 260 pavqaedhssflsgtsgntilagapnfmfpaqqssgePTAiAEip--gSERLEQAGEVKARVKSNEKAPKLKATVKPAQG 337  starlet sea an...
Q5RKG1       318 TTSA---DLASSNNSSLDVLKhmihevehEMEEYERWT-GREVK--GL--Q---GGQgltgftlSLVSSlcrlvRYLKES 386  Norway rat
XP_008118675 318 SASV------NGQNSSLEYLNqmlhdlehDIEEYERWM-GHEVQ--YV--H---SREgvsgfthSLVHAlnrmlHCLKQT 383  green anole
XP_012425407 311 PANLiqtDLQRDSKPSLDVLShmiqeverELEEYERCT-GREVP--KK--E---RSEglsgftlSLVNAlcrlmRYLREA 382  zebra finch
XP_006000127 313 SSTF---NLSNGNQSSLEVLHhmigeveqEMEEFERQT-GRMVK--DQrsQ---TGQgltgftaSLLGTlsrlvRYLKET 383  coelacanth
NP_001121472 305 QH-----DLTASNQSSLGLLNsmiqeveqDLAEYERQT-GREVI--SA--P---PAHgltgftlSLVSSlkrvvSYLKES 371  western clawed...
XP_011487240 307 AASL------SGEQSGLGLLQamlgqveaDLDAFCPQMaSAQSL--KQ--H---KTQsltgfsvALVSTlgrlvHLLRQA 373  Japanese medaka
XP_005797961 309 VASL------SGDQSSLGLLQdmlgqvkaDLDTMSSDI-APEPT--GS--PepyERQgltgfsvSLVSTigrlvQLIRKR 377  southern platy...
XP_005162750 298 LHSL------AGNQSSLELLQsmleqvetELDSLDKQN-PQSSEtrPQ--Q---QRPgltgfsvALLTTlrrltSHIKKR 365  zebrafish
XP_002606849 322 -------DLSSLSLTKLDELKqvmdnleaEIADYEHQA-GMPTP--PP--PqqhKSPtlrgyttSLLEAitrltRHIKES 389  Florida lancelet
XP_001640231 338 PKGL----------RCLDDLKkmvenledEIAEYEMET-GRESS--GK--Tn--QTNsfsgytsALVIAvtklmRYLKES 400  starlet sea an...
Q5RKG1       387 ETQLRKEVETRQQLEQMlGDHRELIDALTAEILLLREENGAVQARLQQ 434  Norway rat
XP_008118675 384 ETKVRQEIINRQQLERElSEHRVLIDALTAEILLMREENFAMQSTFQr 431  green anole
XP_012425407 383 EMQLHEKEMVRQQQKEMlNEHRELIDALTAEVLQVREENITMQKKLQQ 430  zebra finch
XP_006000127 384 EVGVRWGQRETERLREQsREQRQLIDALTAEMLSIREELTVAQTRLQQ 431  coelacanth
NP_001121472 372 DLLLQREVKERQHLQGElVEQRLMLDALTAEILTLKEGNNIHENHLQT 419  western clawed frog
XP_011487240 374 GEDTQKETEGRRRLEGElKEQRGLIDALTAETMALREEAAAVQADLQr 421  Japanese medaka
XP_005797961 378 EAEAQEEAEERRRLQEDlKEQRGLMDALTAETMTLREEGAAMQAGLLQ 425  southern platyfish
XP_005162750 366 DEESLRETRERRRLEDEvKEQRALIDALTVETLTLREESAALQARLQl 413  zebrafish
XP_002606849 390 ESQLRSEATLRHHLMEEiAEQRALVDVLTADIINTQEQYTVLRGEFDQ 437  Florida lancelet
XP_001640231 401 EIQRRAEAVIRDQILQGfAEQRTLIDALTNDIVQTQEQNMILQEEMHV 448  starlet sea anemone
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