Conserved Protein Domain Family
TMEM132D_N

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pfam15705: TMEM132D_N (this model, PSSM-Id:292333 is obsolete and has been replaced by 406196)
Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
TMEM132D_N is the N-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Statistics
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PSSM-Id: 292333
Aligned: 51 rows
Threshold Bit Score: 97.7089
Threshold Setting Gi: 528468856
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6IEE7         45 VSYRLSHTRLAFFLREARpP----SPAVANSSLQRSEPFVVF--Q----T--K--ELPVLNVSLGPFSTSQVVARELLQP 110  human
XP_007247279   47 VNYQVRDAD-YFLLKEAG-Q----DIMRNSSMQSHTQPFVVL--R----A--E--RLPVVNASYGPLSTEREIPLDLVQS 110  Mexican tetra
CAF94499       28 VSYEVRDAD-YLFLKEAG-Q----DIMRNCSMQSHTQPLVIL--K----A--S--AQPAVSASYGTMSTEQLVPRDLVRS 91   spotted green...
XP_002594816    9 LTYE--HADSAYFLQDDF-S----SLFSNGSETVQIDQFALL--R----P--R--EPAVVRASYGPFKVQQSVPHEFLFP 71   Florida lancelet
XP_007668804   60 aSLEPLDVPEFFRLQRTG-H----YPPANASLDSRTETFLFL--R----S--RpaARPLLRASYPPFTAQQEVPGRTPEP 126  platypus
EDL41385       59 VALELLDAPEHFRVQQVG-H----YPPANSSLASRSETFLLM--Q----PwpR--AQPLLRASYPPFATQQVVPPRVTE- 124  house mouse
XP_008114048   34 aELKVLNGPEYFRLQRTD-R----YLPGNASLSSRSETFLFLhrQ----L--T--GKPTIQATYQPFTAQQVVPTDDSQS 100  green anole
XP_010709076  316 VEMELQEVPEHYRLQRAD-G----VLPANTSLHARSDTFLLL--PrhptA--G--PSPLLRASYPPFSTHQEVPTK---- 380  turkey
XP_002942160   28 VSIEVKDVPQYFRLQRAA-PgeesVPTHGNIAQSHSETFIVT--Rl---G--S--REPHVRASYQHLQVQENVPWN-KLG 96   western clawe...
XP_001341924   59 VRITVPSPWQSVPLSQGDlG----LLFTNSSPFTSTQSLLVF--Pps-gT--T--SKPLLRATFGSYTVTQVMS----EP 123  zebrafish
Q6IEE7        111 SSTL-DIPERLTVNWKVRAFIVRSHV-------PASQPVVQVLFYVAGRDW-D----DFGVTER--LPCVRLHAFRDARE 175  human
XP_007247279  111 VQLFrPSPPVFTFNWKVRSFVLTRWV-------YSSSPKVRVLFYIAGRDW-DrgtkDKGTKDE--LPCVTVYAFWQTQE 180  Mexican tetra
CAF94499       92 VQLF-NAPEDFTFNWKIQAFILTPRV-------FSSKPKVRVLFYVAGRDWsR----EEGPGDQ--LPCVTVYAFWQTQE 157  spotted green...
XP_002594816   72 GLNR-TSPGQF-YKLDIRAHLLDKSL-------TPEKSRLGVLFHIVESDL-S----RNEGSGP--LPCIVLHVTMDGKE 135  Florida lancelet
XP_007668804  127 SG--------FSADWDVRAVSVEASV-------SPAEPQARVLFHLKGQDW-------LSGHGG--LPCARLHATHPAGS 182  platypus
EDL41385      125 -------PHRRPVPWDVRAVSVEAAV-------TPAEPYARVLFHLKGQDW-------PPGPGS--LPCARLHATHPAGT 181  house mouse
XP_008114048  101 TDT--------SVTWDVRAVSIEGTV-------SPYEPYTRVLFHLQGQDW-------MSEKKP--LPCVTLYVFHQAQV 156  green anole
XP_010709076  381 -----------SPTWAIRAVPLHSTV-------SPDEPNARVLFHLHGPDW-Rg---RRDPPGDhsLPCIVLQAQQRSQT 438  turkey
XP_002942160   97 ARIR-G----------VQGEVVGDEV-------SPSDPVTRILFHRSGVDG-Q----ARGA--Q--NTCVNVRGTYDGVN 149  western clawe...
XP_001341924  124 IPPL-TSP--------LTASLLSKGVvkemeadRGERFRVRVLFHMRGD------------VNR--GTCVTLHAFKQTEE 180  zebrafish
Q6IEE7        176 H 176  human
XP_007247279  181 V 181  Mexican tetra
CAF94499      158 V 158  spotted green pufferfish
XP_002594816  136 A 136  Florida lancelet
XP_007668804  183 V 183  platypus
EDL41385      182 A 182  house mouse
XP_008114048  157 V 157  green anole
XP_010709076  439 V 439  turkey
XP_002942160  150 V 150  western clawed frog
XP_001341924  181 Q 181  zebrafish
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