Conserved Protein Domain Family
TMEM132D_C
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pfam15706: TMEM132D_C (this model, PSSM-Id:292334 is obsolete and has been replaced by 464814)
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Links
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Statistics
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PSSM-Id: 292334
Aligned: 42 rows
Threshold Bit Score: 76.5577
Created: 1-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002431877  881 NNHEPTVQARQHHSALIPHSnfHVRNSNRMTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFK----------------- 943  human body louse
XP_011672815  868 DKAEASTEAPLDGGN--DGG--LSDDSDPLSGIEIGMYVLLSVFSLAILAFMVNCVMFMARYR----------------- 926  purple sea ur...
XP_002075390  921 HRSNIQAVHKSHFGGKGHGN-------GNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRpaliesgldplsavgkg 993  Drosophila wi...
XP_001963408  887 HRGSIQAVHKNHHGVKGAAG------TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFR----------------- 943  Drosophila an...
XP_001992057  936 HRASIQAVHKTHYGNRASG-----FGSGNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFR----------------- 993  Drosophila gr...
XP_002028124  882 gSSSIQASHKNHFNGKGG--------TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFR----------------- 936  Drosophila pe...
XP_009293643  885 PNFPFPPEEPKREPPLVESN--LIQMFSVFTDIEVCIYALVGLSCLAMIAVLLHCATSSARTR----------------- 945  zebrafish
XP_009025744  745 NNNVQLTSNNNNNNNN------AYQKIRNITPLETAMFVAVVIFCVIVVGLLIHWVVGTACKR----------------- 801  Helobdella ro...
XP_010837933  521 EARKEEAEAREEEEEEGEEE--MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQ----------------- 581  Bison bison b...
ELK33458       21 AGQEEEAEAREEEG--GEEE--MVPAPRRVTNLELGMYALLGIFCLAI-IFLVNRWCLCCTTS----------------- 78   Myotis davidii

XP_002431877  944 A----QvgetvdvsssddnNGANIGvsngnsgykglP---------------------------Q--------------- 977  human body louse
XP_011672815  927 R----A-------------KRMPKT-----------H---------------------------Q--------------- 936  purple sea ur...
XP_002075390  994 N----G-------------NGSIGGfrd-----vrlK---------------------------E--------------- 1009 Drosophila wi...
XP_001963408  944 P----A---------------MIES-----------GldplsvgkgngsggsggsggfrdvrlkE--------------- 978  Drosophila an...
XP_001992057  994 P-------------------VMIES-----------Gldpltgagkgnan--ggvggfrdvrlkE--------------- 1026 Drosophila gr...
XP_002028124  937 P----A-------------LIESGL-----------D---------------------------Plsmgkgsgggggggi 961  Drosophila pe...
XP_009293643  946 N----R-------------KTPIQC-----------Q---------------------------G--------------- 955  zebrafish
XP_009025744  802 RtlkvK-------------DSAGVGs----------G---------------------------G--------------- 816  Helobdella ro...
XP_010837933  582 R----K-------------EPPDGAt----------D---------------------------P--------------- 592  Bison bison b...
ELK33458       79 A----R-------------SPPNGAl----------D---------------------------P--------------- 89   Myotis davidii

XP_002431877  978 ------------STTNVHDWVWLGRATI 993  human body louse
XP_011672815  937 ------------PVPYPQNWVMFGMQEE 952  purple sea urchin
XP_002075390 1010 ------------STTNAHDWVWLGRSTI 1025 Drosophila willistoni
XP_001963408  979 ------------STTNAHDWVWLGRSTI 994  Drosophila ananassae
XP_001992057 1027 ------------STTNAHDWVWLGRSTI 1042 Drosophila grimshawi
XP_002028124  962 sgggfrdvrlkeSTTNAHDWVWLGRSTI 989  Drosophila persimilis
XP_009293643  956 ------------QHEHRHHWVRLSTAAE 971  zebrafish
XP_009025744  817 ------------VCGVENDWVWIGHKTl 832  Helobdella robusta
XP_010837933  593 ------------ASPQPHNWVWLGTDQE 608  Bison bison bison
ELK33458       90 ------------DSPQPYNCMWLGTDQE 105  Myotis davidii
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