3WSX,4N7E


Conserved Protein Domain Family
Sortilin_C

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pfam15901: Sortilin_C (this model, PSSM-Id:292523 is obsolete and has been replaced by 464928)
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Sortilin, neurotensin receptor 3, C-terminal
Sortilin_C is the C-terminal cytoplasmic tail of sortilin, a Vps10p domain-containing family of proteins. Most sortilin is expressed within intracellular compartments, where it chaperones diverse ligands, including proBDNF and acid hydrolases. The sortilin cytoplasmic tail is homologous to mannose 6-phosphate receptor and is required for the intracellular trafficking of cargo proteins via interactions with distinct adaptor molecules. In addition to mediating lysosomal targeting of specific acid hydrolases, the sortilin cytoplasmic tail also directs trafficking of BDNF to the secretory pathway in neurons, where it can be released in response to depolarization to modulate cell survival and synaptic plasticity.
Statistics
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PSSM-Id: 292523
Aligned: 356 rows
Threshold Bit Score: 77.7173
Created: 29-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WSX_A        560 TEPGEKSTVFTIFGSNke--nVhs----wlIL-QVN---------ATDALGv--pCt-------eNDYKL-Wspsd---- 609  human
Q59M21        275 TTIDGTSRKFIIGGIDdsrraEn------eYIySVD---------FTNAFDgk-tCg-------dDDFEE-Fvarksndn 330  Candida albicans
B6JY29        514 ppkslDSLTFLIRAKVkke---------esFI-AID---------FSSILSr--eCtfdekkvanGDFEL-Wypfv---- 567  Schizosacchar...
EPY52505      522 psedpySNIFYLVSEAendgsKr------lIY-SFD---------FGK-FLk--eCrysshesgkNDFEL-Wytny---- 577  Schizosacchar...
XP_001750228  798 TEPSHRESAVSLFYQNddy--------ywvTK-TVDmadasvpyfFDYILTpsfdCflg----ldADFYTeTvpnt---- 860  Monosiga brev...
EDK39138      523 smTDATAAKFILTGIYddtpeNendsefseVVyALD---------FSDAFGgk-vCn-------kNDFEE-Fyarv---n 581  Meyerozyma gu...
EMG49471      524 TTIDGTSRKFIVAGVDpteasDa------eYIySVD---------FTSAFDnk-vCn-------dEDFEE-Fiarq---a 576  Candida malto...
CCE42533      517 TTADGSSRKFLIHGIKpdfnnGed----keLLyHID---------FSEAYNgr-tCk-------dSDFEE-Iyarq---i 571  Candida parap...
XP_007375783  525 TTIDGTSRNFLLAGATser---------teVIyTLD---------FTKAYDgv-tCk-------dDAYEE-Yyars---i 574  Spathaspora p...
XP_011275062  506 TTIDGTTTKFILSGLFrkdnsNsn----sqVIySLD---------FAKAFDk--tCe-------kGDFET-Wygrs---n 559  Wickerhamomyc...
3WSX_A        610 ergNe-CL-LGHKTVFKRRTPHATCFNGed-fDRPVVVSN-CSCTREDYEC-DFG---FKMSe---DLSlevC-VPDPEF 677  human
Q59M21        331 gndEplCV-YGHREKFRRRKQDAKCFVNklfeDIKVIEDP-CQCTEHDFEC-GPG---FRISekesTNV---CvPDRKQL 401  Candida albicans
B6JY29        568 mddTpqCL-MGRIEYYLRKKRAVSCVVRne-vPVHSFVEQiCTCESKDYEC-STY---FEPSd---HFT---CeVNPESL 635  Schizosacchar...
EPY52505      578 engKpaCSeMGRVESFWRKKPDALCSAPkslkKVHHSTKD-CECNESSYEC-NTQ---FSSNe---DGT---C----ELL 642  Schizosacchar...
XP_001750228  861 gttKdvCL-LGGLYSHLRRSSCALCSIDvdqdVHTLTLEHsCACSREDYQClAYGgisFGLSt---S---------PALI 927  Monosiga brev...
EDK39138      582 dkgDpiCI-YGHKEKFKRRKQDAQCFVNkiyeDVETIEEP-CECTELDFEC-GEG---FELHd----gK---CvENAKKI 648  Meyerozyma gu...
EMG49471      577 adnEplCI-YGHVEKFKRRKQDAQCFVNklfeDVKVIEDP-CQCTEFDFEC-APG---FKLSqk-gGHT---CvVDEKQI 646  Candida malto...
CCE42533      572 pdnErlCI-YGHKEKFQRRKQDAECFVNklfeDVKVYEEP-CQCTESDFEC-SLG---FKLSekggD-K---CvPDPKMI 641  Candida parap...
XP_007375783  575 adnPplCI-YGHREKFRRRKQDQACFVNklfeDVKVIDEP-CPCIDLDFEC-ALG---FKSSpk-dQHI---CiPDPAQL 644  Spathaspora p...
XP_011275062  560 eqgEgiCN-FGHRDAFQRRKQDAKCFVNkpfvDLKEVDEP-CSCTELDFEC-NFG---FNKNs---KGE---CvANYNAI 627  Wickerhamomyc...
3WSX_A        678 sgksysppvpCpvg-stYRRTRGYRKISGDTCSGGdv---eARlEgELVPCP 725  human
Q59M21        402 tq-------lCqsks--eitLPNKVLVEGNKC-NMgdkkleDFvSqETLKCS 443  Candida albicans
B6JY29        636 dp-------lCrvdpdatlqLKPYRILLGNSCvpk---kkeEKeKsISMKCP 677  Schizosaccharomyces japonicus yFS275
EPY52505      643 pfvg---sviCaaedgkSFEKFPYRRIPGNTCISKkk---gDFeNpKSFSCd 688  Schizosaccharomyces cryophilus OY26
XP_001750228  928 rrsts-------qpeesTTMVSSYAKIAGDVCEESsls-kqYEaAsVELTCT 971  Monosiga brevicollis MX1
EDK39138      649 gh-------mCrhnkakelsLANKVKIDGTKC-KMgkksesDFvSkQTFKCS 692  Meyerozyma guilliermondii ATCC 6260
EMG49471      647 tk-------mCadkk--elnIPDKVLVQGNIC-DMknkkpeDFiVeQTIDCS 688  Candida maltosa Xu316
CCE42533      642 ak-------lCesqskdvleIYDKSKINGNLC-ELkskkldDFaSkEKLKCS 685  Candida parapsilosis
XP_007375783  645 an-------mCkgqk--elkLEDKVLIDGDKC-DLgkkklsDFiVkETIDCT 686  Spathaspora passalidarum NRRL Y-27907
XP_011275062  628 nk-------iCaesdskdikLQSKRKIPGNPCtg-----gdIStNeQTFNCD 667  Wickerhamomyces ciferrii
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