Conserved Protein Domain Family
HMMR_C
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pfam15908: HMMR_C (this model, PSSM-Id:292530 is obsolete and has been replaced by 464934)
Hyaluronan mediated motility receptor C-terminal
HMMR_C is the C-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.
Links
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Statistics
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PSSM-Id: 292530
Aligned: 8 rows
Threshold Bit Score: 155.414
Created: 16-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O75330        552 RKQLEDEEG---RK-AEKENTTAELTE------EINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI 621  human
XP_010717202  567 KKKSEVEKS---RK-TIHEDMTSSLKE------EIKTWRNLYEELHNKTKPFQQQLDAFEAEKNALLNEQGAAQEELNKL 636  turkey
XP_007474036  565 NKQLVMEET---RK-TREKNM--EFTE------DVKKWRLLYEELYNKTKPFEQQLDAFEAEKRALLNEHGATQEELNKL 632  gray short-ta...
XP_002935941 1011 RTQEEEMEL---LR-KESEKNQQDA-M------EANKWRALYEELQNKVRPFQQQLDAFEAEKNALLNENGAAQDELNKL 1079 western clawe...
XP_005996912  634 QKLLEAEKQ---RKeAVDENTVIKLRA------EAQKWQSLYEELSNKVKPFQEQLDAFEAEKNCLLNENGAAQEELNKL 704  coelacanth
AAQ97980      743 ctQIEEERQdlhRQ-LAEARLQSTSDS------ETEHWRNLYEELYAKVKPFQEQLDRFAAERSALLNEKGATQAELNKL 815  zebrafish
XP_011609096  856 TLQWEMEEQ---RQ--DLQRQVDQAQEksspnsEMEHWRKQYEELFAKVRPFQEQLDAFAAERNALLSENGANQEELNKL 930  torafugu
NP_001011731  681 TLQWEMEEQ---RQ--DLQRQVDQAQE--------KRWEKV--RIYHLFP--QEQLDAFAAERNALLSENGANQEELNKL 743  torafugu

O75330        622 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHH--ESKENF 699  human
XP_010717202  637 SEAYAKLLGHQNQKQKIKHVMKLKEDNTHLQQDISKLRALLAKEKQTNKDLQEQLYTIQGIRRFDPSKAFQH--DSKENI 714  turkey
XP_007474036  633 SESYAKLLGHQNQKQKIKHVMKLKEENNQLKLEVSKLRSQLAKEKQVGKKLQEQINEAKGFKRFDPSKAFQH--ESKENF 710  gray short-ta...
XP_002935941 1080 SEAYAKLLGHQNQKQKIKHVMKLKIENSELKQEVSKLRAQLAKEKQVEKQLQAHLNEIQGVKRFDPSKAFRH--DVKENV 1157 western clawe...
XP_005996912  705 SDAYAKLLGHQNQRQKIKHVVKLKEENSQLRQEVTKLRNQLAKEKQVQKKFEDQMKLAQGVRRFDT---FKH--DSKEND 779  coelacanth
AAQ97980      816 ADAYANLMGHQNQRQKIKHMVKLKEENLELKQEVSKLRSQVGKQKQELDRLKSSE----TTRRFDPSKAFKH--ELKENQ 889  zebrafish
XP_011609096  931 SDAYARLLGHQNQKQKIKHVMKLKDENTSLKQELSKLRSQVSRLKSDQEQLKSMLPGA-PRRRFDPSKAFQHnkENREN- 1008 torafugu
NP_001011731  744 SDAYARLLGHQNQKQKIKHVMKLKDENTSLKQELSKLRSQVSRLKSDQEQLKSMLPGA-PRRRFDPSKAFQHnkENREN- 821  torafugu

O75330        700 ALKTPLKEG 708  human
XP_010717202  715 PPKTPFKEG 723  turkey
XP_007474036  711 SPKVPLKEG 719  gray short-tailed opossum
XP_002935941 1158 MPKAPLREG 1166 western clawed frog
XP_005996912  780 VPSTPLREG 788  coelacanth
AAQ97980      890 KPSSALTQG 898  zebrafish
XP_011609096 1009 EKNEPLREG 1017 torafugu
NP_001011731  822 EKNEPLREG 830  torafugu
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