Conserved Protein Domain Family
TMEM132

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pfam16070: TMEM132 (this model, PSSM-Id:292688 is obsolete and has been replaced by 406471)
Transmembrane protein family 132
This presumed domain is found in members of the TMEM132 family. TMEM132A may be involved in embryonic and postnatal brain development. TMEM132D may be a marker for oligodendrocyte differentiation.
Statistics
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PSSM-Id: 292688
Aligned: 57 rows
Threshold Bit Score: 233.663
Threshold Setting Gi: 514695341
Created: 1-Jul-2015
Updated: 5-Aug-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q17BQ2         436 ELMNTAVLTGRQVSQAMKVFIVSQAG-------KVA--DVTLQ-SSCQAEDESVIK----VSSSCSSVYVDGSEA-RGSS 500   yellow feve...
EFX85492       549 DLVNTAILTSRQVSEPLRVFMVTQAG-------KVA--DVTLQ-ATCSSADESVLK----VSSSCTSVYLDGSEV-RGST 613   common wate...
XP_003138202   352 NLVNTAVLSGKQAAVPMKIFSVTEGG-------NLD--DVTSS-SYCLSAESRVLK----VSPTCSSIYVDGSEL-RGMS 416   eye worm
ERG83463       419 NLINTAILSGRQTSMPMRVLTVSEGG-------LLT--DVTAN-SHCISAESRVLK----TSPTCSSVYVDGSEL-RGMG 483   pig roundworm
XP_003377478   457 aLVNTAVLTGKQIAIPMKVFGVSYAG-------VIR--EVTLS-ANCISKETSVLK----VTPSCTAVYVDGSEV-RGSA 521   Trichinella...
XP_003112928   300 ELMNLAVISGLQVTSSLRIFTVSIGS-------KAE--DVTSQ-SHCISSDANIIK----VSPTCSSVYLDGSES-NGSS 364   Caenorhabdi...
XP_001750073  8018 ELVNTAILSGRPVTSGVTLVSALANG-------TLVlqDPTAAaVSCVAGNTTVLN----VREDCSELLLSGAES-HGQA 8085  Monosiga br...
XP_004990690  7537 fvetTCIVNGGEQTFPLRIVTSDAAGdmq--lvTGT--TGTPG-LSCSSRHPHVWD----VSSDCSSVVLAGDET-SGMT 7606  Salpingoeca...
XP_004995241  1259 ELVNTAVLSGSEETSALSVRAVSSWRpgq--faVVS--AGSPG-LACMSLNTSVLL----ADADCGRVRVTGAES-GGSP 1328  Salpingoeca...
XP_001748068  1865 ELINTAILTGNVEERELAHLIVRRKDlqrfvgfSQE--DSALS-LSCNGSGDGLPAapfgVSVDCHSIFMNSSHSnAGIG 1941  Monosiga br...
Q17BQ2         501 NASV------LVKY----GT-----YSGLAKFTVWMPEFPLEVSVADFRLSQIKGWKI------PE----DhnvsangKM 555   yellow feve...
EFX85492       614 NATL------VARY----GN-----VESTSSLTVWVPEMPLDIQLDDVKLNQISGWKV------MA----T-------SA 661   common wate...
XP_003138202   417 KVKV------HVHF----KT-----MTTSIEVTVWYPRLPITVWLSDPVLNAIKDWQI------AVwkwlP-------SR 468   eye worm
ERG83463       484 KIKV------HVHY----EA-----WTTSIELTVWYPKLPITVWISDPVLNAVKEWQI------AVwk-wL-------PQ 534   pig roundworm
XP_003377478   522 NAII------QVEF----SE-----IKSTVRYTVWFPELPVNIYLKDPVLHAIKNWHV------PV----M-------VD 569   Trichinella...
XP_003112928   365 DAQV------YAHF----LR-----YTTAFSFRVWYPKLPLKIWTSSSTLSTIKNWKVgfwrdlPL----G-------GG 418   Caenorhabdi...
XP_001750073  8086 EASV------IFAL----ARndsavLLAEAHARVWAPTLPVELEVDDTTLRRVANWSW---------------------- 8133  Monosiga br...
XP_004990690  7607 GASIavsvrdAVSN----TT-----ANGDCLGEVWAPQLPIELQADNPMLARVAGWQW---------------------- 7655  Salpingoeca...
XP_004995241  1329 SVGV------SVEY----GG-----QSARVWVRVWYPEEPVQVVLDRDVVRRVARWQ----------------------- 1370  Salpingoeca...
XP_001748068  1942 IVDV------SLTQvgvaEN-----LRSSIKAAVWAPELPVEVLVDRAELHPVAEWID------PS----I-------TN 1993  Monosiga br...
Q17BQ2         556 RRrkRAYGWGHHNEdfv--ngVSPERSVC----RARYQQSPVEVYARFLAVDQD-SGRVSYL--IS-RRTGLRVTD---- 621   yellow feve...
EFX85492       662 -------------A-------SGASANQC----RLRYQQSSFEVFARFYAEDHD-SGRVSYL--IS-RKTYLLITD---- 709   common wate...
XP_003138202   469 RK--REARQ-----------------FGC----INKYQQAEIRILASYYVGDKE-TGERIYL--SGdRDILFDVTS---- 518   eye worm
ERG83463       535 GR--R--------K-------KEARQFGC----TYKFQQAEVRILAAFQVGD-ErTGERIYL--SGqRDTLFDVTA---- 586   pig roundworm
XP_003377478   570 STllNSNKQSISNFtshlmnkRLFDKPNC----RKRYQETEVKIFARFRVDDMl-SGWHSYLgrRG-RQLLFDLTF---- 639   Trichinella...
XP_003112928   419 VK--RS---------------RAARQFAC----VNRFQHGHVKVLASLWIEDQk-TGDQLYL--SShKSILFDVTN---- 470   Caenorhabdi...
XP_001750073  8134 ---------------------FDTDASIC----RPKYQNTRLRAFATFS------YGAQAY---------RARVSS---- 8169  Monosiga br...
XP_004990690  7656 ---------------------FDEDASTC----RDKFQDTRIHAFAMFSRMESGaG------------AVRVRVTKdvsg 7698  Salpingoeca...
XP_004995241  1371 -------RDAGHD-----------ASDGCvslgTSQFQRARVSVVGRFRSGDAv-SAALS----LG-G-------L---- 1415  Salpingoeca...
XP_001748068  1994 I------------------------ADCN----KFQYQTGTVEVRARFSLGNGDs--------------ERVVVTD---- 2027  Monosiga br...
Q17BQ2         622 -LVQPLLRVADPKIA---TL---R----GR-T-LQGRAMGRTDVQVLSP-I-T--GRVIGAR-EVRVGSDKVS------I 677   yellow feve...
EFX85492       710 -LVRKVMRVADPRVA---SL---Km--tSG-F-IEGLKPGKTEVQVLSP-M-S--GHVIAAR-ELRVLADKVD------V 767   common wate...
XP_003138202   519 -LTMNHVHSSNIAVA---VVlprQd---RI-F-VVAHRPGSARITVRSN-T-P--NIDYGSA-PIVVTEDAVS------I 578   eye worm
ERG83463       587 -ISADHVHSSDLGVV---AIh-rHe---GR-IlLNALRPGSARVTVRSH-T-P--NIDYGSA-PVVVTEDPVS------V 646   pig roundworm
XP_003377478   640 -LTKNYLKVTDSEIA---SI---RftanGA-VyLQGLQSGRTEIQVLLP-F-L--RSPYGVS-EVTVVNELVN------I 700   Trichinella...
XP_003112928   471 -IVHNTLQISNRTVA---NV---Kfh-eGRaV-IIGENMGLAKLVVRNA-K-K--SLDLVTE-NISVRNEEVT------T 530   Caenorhabdi...
XP_001750073  8170 -LVVLGASSSNTSVA---RV---Es---DG-Q-VSAWRPGNITIAIDHA-QrQ--GRDLGSV-TLTVLEEDASsalgllV 8233  Monosiga br...
XP_004990690  7699 vLQALDATGAAQSTA---IQ---Mq---GN-V-ARGFRLGSAVVAVINPaV-P--ERTIGNT-TVEAVGS-VP------V 7756  Salpingoeca...
XP_004995241  1416 -LGQSQLAVVNQSVA---RV---Dpv-vSG-H-VQGVGAGQTVVRVLSA-A-VsgSRVIGEA-MLEAQDSYVG------I 1476  Salpingoeca...
XP_001748068  2028 -LLAASLYVNETGVAkmrRL---Vg---AP-M-VQGVAEGSVVVEARRA-S-D--GALLGHSdTIIVGPHDVSpi---vV 2091  Monosiga br...
Q17BQ2         678 TRLLVRVVS------GL-----------QLSISSD-NAIENGY-IA-ETSVTRKLTAQY-QEGLLDIDLEFSDGSRTP-- 734   yellow feve...
EFX85492       768 SRLSVRLIA------GL-----------SLSLSPD-PDLDSCF-VA-QVEASDRLHSRY-QEAILDLTVHFSDGSASP-- 824   common wate...
XP_003138202   579 RRFAVEGVA------DI-----------ALDIERI-PRRAHEY-VV-STFVQNTLTYKY-QHATLVCRLYFSDEQVLE-- 635   eye worm
ERG83463       647 RSITAELVV------DI-----------EVGVMHA-VEKPNEF-LI-SSRILSTLTHRY-QHALLTCRIHYSDEQSTE-- 703   pig roundworm
XP_003377478   701 RSVQLQSVC------FL-----------NVTAANT-DGSDDIH-RL-YVSRIKTFSKRL-QECFLDITLEYSDSTKSS-- 757   Trichinella...
XP_003112928   531 TGLSARPIC------DT-----------NFRILPI-LFSPAFF-KI-EIYHSKTLTKLY-QQCSIFASVSYSDATWEP-- 587   Caenorhabdi...
XP_001750073  8234 SRLELH--A------FT-----------NLTAAPLaSPLVDLDsSS-VVFVHQVFDVED-RVGAVAAYAVFEDGARME-- 8290  Monosiga br...
XP_004990690  7757 PSLGGSTVA------SLlvdelelivftDMTVKPLySPFTGLA-SAsVVSISQALDQEQ-EVGSVAAFARFQDGSRMV-- 7826  Salpingoeca...
XP_004995241  1477 VGLDVVVASavrvsgGM-----------S-ELGND-PGSSAEA-TV-VV-ERDVLDFEG-QRASVFVSAVFEDLTRMElg 1539  Salpingoeca...
XP_001748068  2092 LGLDAILVH------DV-----------DVSLRAG-EGANGTD-LVdVTLRRDSLSEEGiVDANVLVSAVFDDGTRMP-- 2150  Monosiga br...
Q17BQ2         735 ------LR----DISVDDYFLLVESLDTEVVAFAPMLASH--HP--RV---IAVGEG-NGDLLRVTLLLSEECR 790   yellow fever mosq...
EFX85492       825 ------LR----LTDRSHYNLVVESHNTSILALTSPARAN--IP--RV---LALGEG-RATL---SVTFSSACt 877   common water flea
XP_003138202   636 ------LT----DIPSEQYVLRGWSSDEQAIALNHGPGGH--NI--EL---IVLQNA-KNVIISVSLHSPVQCs 691   eye worm
ERG83463       704 ------LS----DIGVEEYMLNVWSGDERSLAVIHRNSHA--LV--EL---IALDDT-HDAVINAELRGPPHCv 759   pig roundworm
XP_003377478   758 ------VQ----NLPEADYEAIVQSDERSLLILESDLG----FP--ALfryLNLDEE-KAGHIRASLYGAATCg 814   Trichinella spiralis
XP_003112928   588 ------LN----DLDSSYFEMSAHSDNERALAVSHHASKV--H----V---IAIDEHwPLPSVEIALQSSSQCA 642   Caenorhabditis re...
XP_001750073  8291 ------LS--------PEQGLRLNSLDPAVLAVSATGVSSydHA--HV---VAKGAG-SGPLLQGTWL--AECA 8342  Monosiga brevicol...
XP_004990690  7827 ------VG------PETGLRLSVDQANRGVIAVPSTGDLV--FDnrHV---LAQGSG-SGNLLSATWTVLCEsp 7882  Salpingoeca rosetta
XP_004995241  1540 vgrevrLR----TLAPGTVRVVGNGAEPGVIVVPGRA-----------------VDG-SGELIEAIWQGGNANA 1591  Salpingoeca rosetta
XP_001748068  2151 ------LSvepaVLQSSDGNVSVHSLAPASLSV--DATQT--IA--VV---RDAVNS-EGGLLEAVWLSAASAA 2208  Monosiga brevicol...
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