1DEB


Conserved Protein Domain Family
APC_N_CC
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pfam16689: APC_N_CC (this model, PSSM-Id:293294 is obsolete and has been replaced by 435517)
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Coiled-coil N-terminus of APC, dimerization domain
APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumor-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.
Links
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Statistics
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PSSM-Id: 293294
Aligned: 7 rows
Threshold Bit Score: 69.5844
Created: 13-Apr-2017
Updated: 23-May-2017
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1DEB_A          3 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 54   human
XP_017566261    4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55   red-bellied piranha
XP_018668496   59 SRYDQLLQQVECLKLENTTLKKELSNNSSQISKLESEALNLKEMVVMLGNSI 110  vase tunicate
XP_012810058   14 ASYDQLVRQVEDLKKENSHLRRELKDNSSQLNRLEHDTSDMKEVLKhlqvkl 65   western clawed frog
XP_008293898    6 ASYDQLAHQVEALRKENSHLRRELEDNSNHLSKLETETFGMKEVLKQLQSKL 57   bicolor damselfish
XP_004023394    6 AAYEQLVRQGEALXAADShLRQELRDNSSHLSKLETETSGMKAVLQHLQGKL 57   sheep
OBS74820        6 ASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKL 57   desert woodrat
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