1FSU


Conserved Protein Domain Family
4-S

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cd16029: 4-S 
Click on image for an interactive view with Cn3D
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Statistics
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PSSM-Id: 293753
Aligned: 77 rows
Threshold Bit Score: 351.467
Created: 10-Sep-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:predicted based on homologous protein and on human 4-Sulfatase with Ca++ bound at the active site

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                 ##                                             #                        
1FSU_A          4 PHLVFLLADDLGWNDVGFHGSri---------rTPHLDALAAGGVLLDNYYTqPLXTPSRSQLLTGRYQIRTGLQhqiiw 74   human
XP_002733875   26 PNIIFILADDLGYFDVGYREGsi--------vkTPNIDKLAAEGVKLERYYAqSSCMPSRSCLMMGRYQIHTGFDyrcld 97   Saccoglossus ...
XP_005789095   27 PHIVLILAVDYGHANLGYNARktgnkqliaetnTPNLDALIDDGVYLSQHYSyAVCAPSRSSLQSGRFGSHVNMFntape 106  Emiliania hux...
XP_009032337   27 PHLLFVLGDDVGFGDVGYSSPdv---------iSPTLDRLAAEGLKLGRHYAyMWCAPSRAALLTGYYPSTTGVYstsga 97   Aureococcus a...
XP_009034961  118 PHLVLILADDMGYNDIGYNRAphqt----nqvsTPFLDELASEGVTLTRYYTqCDCSPSRGALLTGLYPASTGLYhgviv 193  Aureococcus a...
XP_009032473   33 PHVFLIVADDLGYGDVSYNGDgslt----navaTPYLDRLAADGITLTRFYSqCDCTPARAALLTGRYPSNTGMQhevvt 108  Aureococcus a...
XP_009035018  197 QNILLILADDMGYNDVGYQSTdlg-------aaTPTLDSLASRGVELASYYTlPSCTPARSSLFTANYAANNGMGydgpg 269  Aureococcus a...
XP_009039485   73 PHVVIALLDDMGYNDAPWTSTdlg-------aaMPFARRLAADGVVLSNYYAdQSCTPSRAALLTGRHAVELGVYstvvw 145  Aureococcus a...
XP_009037360 1095 PDIVLVFMDDVGLNDLWRSTDlp---------kPTEMSKLVRDGVELTSYYGqSLCSPARATLMTGKFAHKIGFSdqqgg 1165 Aureococcus a...
XP_005793680  630 PHLVFVLTDDVGFNDFHDSSDig--------eaWNNTRALLSEAIQINSTYTeTISIPSRRSFLTGRQARLVTPGregqd 701  Emiliania hux...
Feature 1                                             # #                                         
1FSU_A         75 pcq-------pscvpldEKLLPQLLKEAGYTTHMVGKWHLGMyrkecLPTRRGFDTYFGYLLGSEDYYSHerctlidaln 147  human
XP_002733875   98 gql------trlcmapdTVTLPMKLRQYGYATHMIGKWHLGHerkecVPTHKGFDTFFGYHGAAENYYTHtalgrprchd 171  Saccoglossus ...
XP_005789095  107 avnsadpisgyagipvaMTGMAEVLKSAGYRTHGVGKWDIGMatpahSPFGKGYETFIGYYQHANDYWNKrgsflatgev 186  Emiliania hux...
XP_009032337   98 qn---------alplefALLPGLLRDRAGYRTAAVGKWHLGFmseadLPERRGFDGFFGFLDGGEDHYSRvgagapgcdr 168  Aureococcus a...
XP_009034961  194 tq--------shwglplEYHLIPQFLPSRYRSHAIGKWDVGHytwnhVPTGRGFHSYVGFYGTDIDYYTHeigagcnsyn 265  Aureococcus a...
XP_009032473  109 aq--------sqwslphEFALLPSALPEGYRKHAIGKWDVGHaraadTPTARGFDSHLGYYGAEITYDEHaalrscsngt 180  Aureococcus a...
XP_009035018  270 tyvi----dssyglplgATLMSEVLKGRGYATHIETYFSHEAy---gTDPNNGTSYCDLMRSNSVDGVKVgec------- 335  Aureococcus a...
XP_009039485  146 dsaw-----gldenaktLPALIEDARPGAYHKACVGKWDVGHstaayLPLARGFDTFTGMLGDMMTDYSThmaeftssgp 220  Aureococcus a...
XP_009037360 1166 vrevt--aysnfsvplgHDMLPQGMKRLGYQTHAIGKWNIGHcnvkyMPWQRGFDTFVGYFTDGIGYTDHvsdtantytv 1243 Aureococcus a...
XP_005793680  702 -------------wsknETTIAHKLLAQGYVTYAIGKWFAGYtswtiAPTGRGFARFFGQYENIYSYNSPctkpaknddk 768  Emiliania hux...
Feature 1                                                                                         
1FSU_A        148 vtrca--------------------------------ldfrdgeevatgykNMYSTNIFTKRAIALITNHPp---eKPLF 192  human
XP_002733875  172 lw--------------------------------------rnmenvaedydGQYSTLFYTKEAQDIIKNHDk---kKPFF 210  Saccoglossus ...
XP_005789095  187 dmclslmldffsynetyrggnpnpgqvtdsckcqegtetgcqnggdentypSCFEETIFMNAAMDRIRAHDtsqpqHPLF 266  Emiliania hux...
XP_009032337  169 vfdlw-------------------------------dsrrrgpatddpsafGRYSAELYGEAAADAIRGHDa---aEPLF 214  Aureococcus a...
XP_009034961  266 cssaikrcm-----------------------ndsitdlnydgaatgdeyyNRYSTDIFTDRAVELLRTESa---rNPLF 319  Aureococcus a...
XP_009032473  181 ird------------------------------------mnhdgatlaateDRYSTHLFADHAMALVDREAd---eYKLF 221  Aureococcus a...
XP_009035018  336 -------------------------------------------------ylDEYSTDLYARRLVDVVGEHAtt-sdSPLF 365  Aureococcus a...
XP_009039485  221 vyd------------------------------------lfegdapsydyqNTYATDIWTSAATSAVAAAHea--aKGLL 262  Aureococcus a...
XP_009037360 1244 nd--------------------------------------gglafngseyeGTYTTALFTERAEKVLHDAPe---dAPLF 1282 Aureococcus a...
XP_005793680  769 prwdtfyseampfe--------------trdasfeapflrygleaigpdgnGRYKTELYDDKATAFIEQHKlyhpdKPLF 834  Emiliania hux...
Feature 1                 #                                                                       
1FSU_A        193 LYLALQSVHEPLQVPeeylkpy-----------------------------dfiqdknRHHYAGMVSLMDEAVGNVTAAL 243  human
XP_002733875  211 MYLSYQAVHGPLEVPsnyrmpyy----------------------------tsgvdesRQIYAAMATCMDEGIGNITETL 262  Saccoglossus ...
XP_005789095  267 LFHSFHFLHTPLEAPiaairelnqtir--------------------dkggdpinlesRLMYNSMVLLMDKIVGRLVQTL 326  Emiliania hux...
XP_009032337  215 LYAAFQVAHSPLEVPpakyfdayadaalcanastkgfacarpgadapyrapnhdcgcdRLVVAAMVTALDAAVANMTTAL 294  Aureococcus a...
XP_009034961  320 LYVAFNAVHGPLEADdatidrfna-------------------------sflyearteRATFAAAALLMDRAVESIVKTM 374  Aureococcus a...
XP_009032473  222 LYLCFQAVHQPLAADaalvkrfad-------------------------afldesdaaRSTFAAVALELDRAVERFVEFT 276  Aureococcus a...
XP_009035018  366 LYFAAQAPHAPLEEPppmnatapqeaml------------------aalvgagdswgkRRTFAKMVMNLDNNVRKVVDAL 427  Aureococcus a...
XP_009039485  263 LYLAYNAIHTAITLPknfeeddeykal-------------------vapldagdyteqRQLAAGALLVVDRSLETLFQTL 323  Aureococcus a...
XP_009037360 1283 MWLAYHGMHDNDGVTdadtcaqtgdddd-----------------daifmerghlpfaRFNFGCGLRAIDRGVGQVRTAL 1345 Aureococcus a...
XP_005793680  835 LYYAPVPIRGAGGDKsdhpdeymda-----------------------pacagldnerRRKACAAAVALDESVGHVASAL 891  Emiliania hux...
Feature 1                         ##                                                              
1FSU_A        244 Kss-glWNNTVFIFSTDNGGQTlag---gnNWPLRGRKWSLWEGGVRGVGFVASPLLk------qKGVKNRELIHISDWL 313  human
XP_002733875  263 Kas-gmLNNTILVFSSDNGAQFhtg---grNWPLRGGKGTMWEGGVRVLAFVNSPLLk------kSRTVNHEMIHTSDWF 332  Saccoglossus ...
XP_005789095  327 Vgk-gmFENTLLAFLSDNGGPIylpa-ganNYPLKGGKWSDWQGGVLANAFISGGVVpa----siRGTVHAGIFSIADWY 400  Emiliania hux...
XP_009032337  295 Ask--nMADFVLVYSGDNGGPEieg---hwNGGLRGGKWTWFEGGVRPAAFVHSPLLt-------RRGWHNGTLHLVDWL 362  Aureococcus a...
XP_009034961  375 Hav-gaYDNSIVLFASDNGATLaqtg-ggsNWPLRGSKFTPYEGGVRVPAFLHSPLLgs----grRGITHAGLFHVTDIL 448  Aureococcus a...
XP_009032473  277 Kar-gaYDDAVFFFMSDNGATLaqsg-ggsNWPLRGSKFTAYEGGVRVPAFLHSARVpp----arRGAAHAGLFHVVDVL 350  Aureococcus a...
XP_009035018  428 Aaa-klLQNTVVAFASDNGGCPrdg---gsNWPLRGTKFSQYEGGVRVPAFLWSSTLqk----rgAGTVFEGLFHVADWF 499  Aureococcus a...
XP_009039485  324 Daa-gmTDDTLLFFGSDNGGLTgfg---gsNYPLRGEKLTLFEGGVRVPAFFWAGASfprf-ratAGAAYGGIVHVSDVA 398  Aureococcus a...
XP_009037360 1346 Dd---rARDYVLVVTSDNGGFAcgyhcqgsNYPYRGAKFYEFEGGLRLPGVVYSPSRvpa---rrRGAAYDGLMHHVDWF 1419 Aureococcus a...
XP_005793680  892 NtgayaNDDHVVAMTADNGAGTwrvssggsNAPLRGNKYEVFEGGVRLKALVWGRHPglasspllGQTYTGGRVQLIDWH 971  Emiliania hux...
Feature 1                                                                                         
1FSU_A        314 PTLVKLARGHTNgt-----kpLDGFDVWKTISegsp---spriELLHNIdpnfvdsspcprnsmapakddsslpeysafn 385  human
XP_002733875  333 PTFVRLAGGTVDdv------eLDGVDQWDTIStgap---tkrqELLIQIsgrrgaledigkdp---------witndyfd 394  Saccoglossus ...
XP_005789095  401 TTFAEVAGLYDNdemkypvslDDGVLVDQKAKaandwmdanrlDETTNPrlppldgvpqwaailagr-dardgnpihisp 479  Emiliania hux...
XP_009032337  363 PTFLALAGAARDdd------aFDGADQWASLAfgaa---pareATLIGPg------------------------------ 403  Aureococcus a...
XP_009034961  449 PTLVHAAGGSPPs-------dIDGVNQYHALFgsdatasspraDVLVHVdvygyete---------------------am 500  Aureococcus a...
XP_009032473  351 PTLAAFAESADRvp-----agVDGVDQRDAVLhgaa---aprtEALLHAddlgyert---------------------sm 401  Aureococcus a...
XP_009035018  500 PTLVASAGVRATvg------kIDGVNQYDALFdatqn--aprdEVLIHLnkwtpgadha----------------aataf 555  Aureococcus a...
XP_009039485  399 PTLFGAAFGGYDa--------VSGLDLSGAVLagded-aktreRLVYAAtvadfsedas----------------wdsag 453  Aureococcus a...
XP_009037360 1420 GTFVHLGGGDVAaltt-fdssFDTMNHWPQIAgsagagsagreTIIFAAsds---------------------------- 1470 Aureococcus a...
XP_005793680  972 ATFAALGGHVDIstse--evvNAGLDVWAAITnnsa---sprtEMIVAKdfytr-------------------------- 1020 Emiliania hux...
Feature 1                                                                                         
1FSU_A        386 tsvhaAIRHGNWKLLTGYPgcgywfpppsqynv----------------------------------------------s 419  human
XP_002733875  395 itraaSIIVGRWKLVTGQYrspktwvpppelnype------------------------------------------dhi 432  Saccoglossus ...
XP_005789095  480 qalvwKQDAGLLKLVTGKQyfgrhvgpvfpncstlqsgqnlqgparqtv---------------kfldiqyepstnqeqi 544  Emiliania hux...
XP_009032337  404 -----VLVQGNYKLYAVPPagfgecsvfntatwdctlgrrgqplaapadvkadg-----nasrcprlqcsagpfddpada 473  Aureococcus a...
XP_009034961  501 glatgAYIEGDLKVVVNATeatwcapdsetyryadecwdlp------------------------------atycdkvae 550  Aureococcus a...
XP_009032473  402 gfwtgAFLRGRYKVVINATaagwcspdseryrydakcwtlp------------------------------ttywadvhd 451  Aureococcus a...
XP_009035018  556 daapaALRWKHWKLIVNEGpmvvnapamnasw------------------------------------------------ 587  Aureococcus a...
XP_009039485  454 tsvvaAYRDGRYKLLTNAPwcdaattdamc-------------------------------------------------- 483  Aureococcus a...
XP_009037360 1471 ---taSIRSGAYKYTYNAVnvtwfmpsfngtid----------------------------------------------s 1501 Aureococcus a...
XP_005793680 1021 -qagvAFWQGPWKLMVGVAygpdpnlncdggaygpacevpgdsvlqhlghsfpvrsgdndaylqvqsydvyvgptcncle 1099 Emiliania hux...
Feature 1                                     
1FSU_A        420 eipssdpptktlwLFDIDRDPEERHDLS 447  human
XP_002733875  433 mppsteilgkmvwLFDLEEDQNEKNDLS 460  Saccoglossus kowalevskii
XP_005789095  545 dtltwtedcgggcLYDLASDPTESNDLA 572  Emiliania huxleyi CCMP1516
XP_009032337  474 wlcsapcsldkpcLYDVVSDPAEARDVA 501  Aureococcus anophagefferens
XP_009034961  551 nksgyaayfhktyLFDLSVDPEEQHDLK 578  Aureococcus anophagefferens
XP_009032473  452 gagtysqyfnesyLFDVVEDPSERTDLR 479  Aureococcus anophagefferens
XP_009035018  588 cacsltahsstsyLFNLANDKNESVDVR 615  Aureococcus anophagefferens
XP_009039485  484 ---qcacdgqrtyVFDLEADPTETTNLV 508  Aureococcus anophagefferens
XP_009037360 1502 dparcdgsspatqLFDVKEDPREEIDLA 1529 Aureococcus anophagefferens
XP_005793680 1100 gffpkgpfgsgysLYNIDNDPEEQDNRT 1127 Emiliania huxleyi CCMP1516

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