4HB5,1AWC,1BI7,4BSZ,2ETC,3LVQ,4XCZ,2FO1,2FO1,2FO1,4OT9,4OT9,3J5P,3JXI,4DX1,4N5Q,2F37,2RFA,4G8K,1DCQ,3JXI,4DX1,2RFA,3JUE,1S70,1K1B,1K3Z,1OY3,4B93,1NFI,1K1B,1K3Z,2DZN,2DZN,2F8X,1BI8,1OT8,1QYM,2DVW,2F8X,3B7B,3HRA,4G8K,4G8K,4HBD,4OAU,4O1O,3UTM,3LJN,1D9S,1IKN,1N11,1N11,1N11,1N11,1N11,1OT8,1OT8,1OY3,1QYM,1QYM,1S70,1SW6,1YCS,2BKG,2BKG,2DZN,2F8X,2F8X,2F8Y,2P2C,2QC9,2RFM,2RFM,2VGE,3AAA,3B7B,3B7B,3B7B,3C5R,3D9H,3EHQ,3EU9,3EU9,3F6Q,3TWU,3UTM,3V2O,3V2O,3V30,3ZKJ,3ZKJ,3ZNG,4B93,4B93,4CYM,4G8K,4G8K,4NIK,4O1O,4TUM,4UUC,4UUC,1AP7,1BD8,1G3N,3DEO,3LJN


Conserved Protein Domain Family
ANK

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sd00045: ANK 
Click on image for an interactive view with Cn3D
ankyrin repeats
Ankyrin repeats are one of the most abundant repeat motifs, and generally function as scaffolds for protein-protein interactions in processes including cell cycle, transcriptional regulation, signal transduction, vesicular trafficking, and inflammatory response. Although predominantly found in eukaryotic proteins, they are also found in some bacterial and viral proteins. Less is known of their physiological roles in prokaryotes. Some bacterial ANK proteins play key roles in microbial pathogenesis by mimicking or manipulating host function(s). The pathogen Providencia alcalifaciens N-formyltransferase ankyrin repeats function in small molecule binding and allosteric control. Ankyrin-repeat proteins have been associated with a number of human diseases.
Statistics
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PSSM-Id: 293786
View PSSM: sd00045
Aligned: 108 rows
Threshold Bit Score: 64.1292
Threshold Setting Gi: 6137552
Created: 24-May-2001
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 29 residues -Click on image for an interactive view with Cn3D
Feature 1:ANK repeat [structural motif]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     #############    ############     ####                                          
4HB5_A     36 DGRTPLHYAAENGh---KEIVKLLLSKGAd---pNAKDs--------DGRTPLHYAAENGh----KEIVKLLLSK-GADp 96  Metallosphaera yel...
4XCZ_A    290 DNFDEILTACEDKs---PEFISKLLKTENi---lFEKNh--------LGWSPIIIAAYHGn----MDVIEWLVSK-GVNi 350 Providencia alcali...
2FO1_E    234 NGXTALXIVAHNEgrdqVASAKLLVEKGAk---vDYDGaarkdsekyKGRTALHYAAQVSn----XPIVKYLVGEkGSNk 306 nematode
2FO1_E    198 SERSALHQAAANRd---FGXXVYXLNSTKlkgdiEELDr--------NGXTALXIVAHNEgr-dqVASAKLLVEK-GAKv 264 nematode
2FO1_E    165 DENTPLXLAVLARr---RRLVAYLXKAGAd---pTIYNk--------SERSALHQAAANRd----FGXXVYXLNStKLKg 226 nematode
2DZN_A     35 DGRIPLHWSVSFQa---HEITSFLLSKMEnvnldDYPDd--------SGWTPFHIACSVGn----LEVVKSLYDR-PLKp 98  Saccharomyces cere...
4G8K_A    167 GGATALMDAAEKGh---VEVLKILLDEMGad--vNACDn--------MGRNALIHALLSSddsdvEAITHLLLDH-GADv 232 human
4OAU_C    147 GGATALMDAAEKGh---VEVLKILLDEMGad--vNACDn--------MGRNALIHALLSSddsdvEAITHLLLDH-GADv 212 human
1OT8_A    117 DGTTPLILAARLAi---EGMVEDLITADAd---iNAADn--------SGKTALHWAAAVNn----TEAVNILLMH-HANr 177 fruit fly
2F8X_K    124 DGTTPLILAARLAv---EGMLEDLINSHAd---vNAVDd--------LGKSALHWAAAVNn----VDAAVVLLKN-GANk 184 human
Feature 1                                                         
4HB5_A     97 --NAKDs--------DGRTPLHYAAENGh----KEIVKLLLSKGAd-pNTSD 133 Metallosphaera yellowstonensis MK1
4XCZ_A    351 --NDRNy--------KGTTVAMYFKDYMlrsgnYTGLENLINLGLd-lFLKD 391 Providencia alcalifaciens
2FO1_E    307 --DKQDe--------DGKTPIXLAAQEGr----IEVVXYLIQQGAs-vEAVD 343 nematode
2FO1_E    265 --DYDGaarkdsekyKGRTALHYAAQVSn----XPIVKYLVGEKGsnkDKQD 310 nematode
2FO1_E    227 diEELDr--------NGXTALXIVAHNEgr-dqVASAKLLVEKGAk-vDYDG 268 nematode
2DZN_A     99 dlNKITn--------QGVTCLHLAVGKKw----FEVSQFLIENGAs-vRIKD 137 Saccharomyces cerevisiae S288c
4G8K_A    233 --NVRGe--------RGKTPLILAVEKKh----LGLVQRLLEQEHieiNDTD 270 human
4OAU_C    213 --NVRGe--------RGKTPLILAVEKKh----LGLVQRLLEQEHieiNDTD 250 human
1OT8_A    178 --DAQDd--------KDETPLFLAAREGs----YEASKALLDNFAn-rEITD 214 fruit fly
2F8X_K    185 --DMQNn--------REETPLFLAAREGs----YETAKVLLDHFAn-rDITD 221 human

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