2NYL,2OT8,4JLQ,4I5L,1OYZ,2NYL,4HMY,2IE3,4ADY,4I5L,2BPT,3W3V,1W63,3W3T,2XA7,4HMY,3W3V,2QNA


Conserved Protein Domain Family
HEAT
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sd00044: HEAT 
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HEAT repeats
The canonical HEAT repeat consists of two helices forming a helical hairpin. HEAT repeats are found in a diverse family of proteins, including the four proteins from which its name is based: Huntingtin, Elongation factor 3, the PR65/A subunit of protein phosphatase 2A (PP2A), and the lipid kinase TOR (target of rapamycin). The HEAT repeat family is related to armadillo (ARM)/beta-catenin-like repeats.
Links
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Statistics
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PSSM-Id: 293787
Aligned: 99 rows
Threshold Bit Score: 34.3903
Created: 30-May-2013
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
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  next features
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                        ##  #  ##                                 ##  # 
2NYL_A         6 IAVLIDELRNed----------------vqLRLNSIKKLSTialalgv--ertrseLLPFLTDTIYDed--eVLLALAEQ 65  human
2OT8_A       361 LPLLKELLFHhe----------------wvVKESGILVLGAiaegcmqgmipylpeLIPHLIQCLSDkk-alVRSITCWT 423 human
WP_013011966  96 VAFLTSIMDHen----------------keVRKLILDSLVAtss----------kySIPALRAALRDka-pnVMITAIEY 148 Denitrovibrio a...
WP_011697741 104 VDVLMELAALtrs---------------elVMRNCYHALAAigg----------erPGQFLLAAYDKtprqdIRADLIDL 158 Syntrophobacter...
WP_014048322 474 LAGLTALRAGgatpevlrvlrgapeyrgewLRTAALRALDAfgpa--------areAVPELRALIRRpg--tAATEAAEA 543 Streptomyces
WP_012927871  90 IALLLIGFAGgllythwr-----sadastqLANSTASATPEv--------------AIKKVLAFESN-----PKTSASER 145 Spirosoma linguale
WP_012671291  34 ISTNTSAAETsgmlnaeye--kafkygtptQKIATIAKIKRtkn----------eaDIAMLANHYPEeknnrVKSEIINF 101 Brachyspira hyo...
Q09543        15 IAVLIDELRNed----------------vtLRLNSIRKLSTialalgv--ertrneLIQFLTDTIYDed--eVLLVLAEQ 74  Caenorhabditis ...
XP_001704098   9 IAVLIDDLKNed----------------anARLSAVKRIDQiavalgp--krtrdeFIPFLCECVDDdd--eILIELAQK 68  Giardia lamblia...
Q7ZUL5       115 LPIVVRYLADqn----------------nlVRKTSQAALLVlleqelmeradvetlVCPVLVDLTAPdsnddVKTEAMAI 178 zebrafish

Feature 1         ##  #                               ##  #  ##  #                              #
2NYL_A        66 LGTFTTlvggp---eyvhCLLPPLESLATVEet-vVRDKAVESLRAISHEhsps--dleaHFVPLVKRLAGGdw-ftSRT 138 human
2OT8_A       424 LSRYAHwvvsqppdtylkPLMTELLKRILDSnk-rVQEAACSAFATLEEEactelvpylaYILDTLVFAFSKyq-hkNLL 501 human
WP_013011966 149 LGKIYDe-----------ESLNDVMEIFETStepmVRSACLETLTIMGSPdn------vdRVLAVLGAGGMDs---fYKP 208 Denitrovibrio a...
WP_011697741 159 LCQMGYe-----------AALPRTEGILKKD----FDEYYYESVFAFGKMg--------dKATPFLLGKIEDpd-rnVRM 214 Syntrophobacter...
WP_014048322 544 LWSVEGda---------gAVLPVLLEGLGAErv-hDCRAAAVALGRLGGEa--------aVAVPRLRALLAHde-lwLRV 604 Streptomyces
WP_012927871 146 IQAINQsfelt---qadrDITQLLINTLNFDpnvnVRLAACQALVRFENEp---------VVRNALIQSLQIqtdpnVQI 213 Spirosoma linguale
WP_012671291 102 FKQNKNd-----------NAKAIIEYAIKDEnd-sVRKDAYYLCSIYPDIq---------YEVPIMSEITNAtg--lVLD 158 Brachyspira hyo...
Q09543        75 LGNFTPlvggp---dhvhCLLLPLENLATVEet-vVRDKAVESLRKIADKhssa--sleeHFVPMLRRLATGdw-ftSRT 147 Caenorhabditis ...
XP_001704098  69 LGKFVDpvggp---nyapTLLNPLRLLACADsk-lVRDEAIASAVRVGSKltdk--dfatSFVPMVEALIKGew-ynHRT 141 Giardia lamblia...
Q7ZUL5       179 ICKMAPmvgkd---iterLFLPRFCEMCCDCrmfhVRKVCAANFGDICSVvggd--ateeLLLPRFFQLCSDnv-wgVRK 252 zebrafish

Feature 1        #  #  ##                                      ##  #  ## 
2NYL_A       139 SACGLFSVcyprv-----ssavKAELRQYFRNLCSDdt----pxVRRAAASKLGEF 185 human
2OT8_A       502 ILYDAIGTladsvghhlnkpeyIQMLMPPLIQKWNMlkd--edkDLFPLLECLSSV 555 human
WP_013011966 209 SVIRLAGEk------------gGSRHLEFLLSFLNNkntmyfreISNGILKIISRE 252 Denitrovibrio acetiphilus
WP_011697741 215 HSIHVLGLwl----------mpLEAAQPLRDHYWKEpd----peLRSLVLSSLERV 256 Syntrophobacter fumaroxidans
WP_014048322 605 DAAVALWEis----------grTGESVPVLLAAWEQnr-----hVRVRVAQCLVRM 645 Streptomyces
WP_012927871 214 TLIDVLVAi------------kEKRAVTEIQRLAQNqqv--leaVRIKAAEGITRL 255 Spirosoma linguale
WP_012671291 159 SMVNALGAi------------kSEMAADYLLEIYTNntv--gssTKVEILRYFSET 200 Brachyspira hyodysenteriae
Q09543       148 SACGLFSVvyprv-----spaiKSELKSMFRTLCRDdt----pmVRRAAAAKLGEF 194 Caenorhabditis elegans
XP_001704098 142 SGVGLAHLvfkrc----ttstiRNDLLEAIQRLAQDtl----pmVRRTVAECLSQI 189 Giardia lamblia ATCC 50803
Q7ZUL5       253 ACAECFMSvssas----spevrRSKLSAVFISLISDps----rwVRQAAFQSLGQF 300 zebrafish

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