3FMO,1ERJ,1GXR,1JV2,1K8K,1P22,1PEV,1S4U,1TBG,1VYH,1YFQ,2B4E,2GNQ,2PM9,2VDU,2ZKQ,3ACP,3DW8,3FM0,3GFC,3GRE,3I2N,3JPX


Conserved Protein Domain Family
7WD40

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sd00039: 7WD40 
Click on image for an interactive view with Cn3D
WD40 repeats in seven bladed beta propellers
The WD40 repeat is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD dipeptides lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel beta-sheet. The WD40 sequence repeat originally described in literature forms the first three strands of one blade and the last strand in the next blade. The C-terminal WD40 repeat completes the blade structure of the N-terminal WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands, allowing them to bind either stably or reversibly.
Statistics
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PSSM-Id: 293791
View PSSM: sd00039
Aligned: 23 rows
Threshold Bit Score: 73.5357
Threshold Setting Gi: 16975253
Created: 23-Feb-2015
Updated: 6-Nov-2015
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:WD40 repeat [structural motif]
Evidence:
  • None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ######         ######             #######                     ## #####          
3FMO_A     39 SSLLAVsnk----ygLVFAGGa------------SGLQIFPtknlliqnkpgddpnkivdkvQG-LLVPMkf-------- 93   human
1JV2_A     20 GFAVDFfvpsassrmFLLVGApkanttqpgivegGQVLKCDwss----------------trRC-QPIEFdatgnrdyak 82   human
1K8K_C     11 ISCHAWnkd----rtQIAICPn-----------nHEVHIYEksg---------------nkwVQvHELKEhng------- 53   cow
1PEV_A     21 AVVLGNtpa----gdKIQYCNg------------TSVYTVPvgs----------------ltDT-EIYTEhsh------- 60   nematode
1S4U_X     29 IFSVSAcn------sFTVSCSg-----------dGYLKVWDnklldn----------enpkdKS-YSHFVhks------- 73   baker's yeast
1YFQ_A     14 ISDIKIips----ksLLLITSw-----------dGSLTVYKfdiq-------------aknvDLlQSLRYkh-------- 57   baker's yeast
2B4E_A     37 SGFCAVnp------kFMALICeas--------ggGAFLVLPlgktg------------rvdkNV-PLVCGhta------- 82   house mouse
3ACP_A     96 YTAVDTakl---qmrRFILGTt-----------eGDIKVLDsn------------------fNLqREIDQahv------- 136  baker's yeast
3DW8_B     31 ISTVEFnhs----geLLATGDk-----------gGRVVIFQqeqenkiq------shsrgeyNVySTFQShepefdylk- 88   Norway rat
3GRE_A     66 ITSSAVspg---etpYLITGSd-----------qGVIKIWNlkeii-----------vgevySSsLTYDCss-------- 112  baker's yeast
Feature 1                                                                                     
3FMO_A     94 -----------piHHLALScd-------nlTLSACMmsse----------ygsIIAFFdvrtfsn--------------- 130  human
1JV2_A     83 ddplefkshqwfgASVRSKq---------dKILACAplyhwrtemkqerepvgTCFLQdg-------------------- 133  human
1K8K_C     54 -----------qvTGVDWApd-------snRIVTCGtd--------------rNAYVWtlkg------------------ 83   cow
1PEV_A     61 -----------qtTVAKTSps-------gyYCASGDvh--------------gNVRIWdttq------------------ 90   nematode
1S4U_X     74 -----------glHHVDVLqaierdafelcLVATTSfs--------------gDLLFYritrede--------------- 113  baker's yeast
1YFQ_A     58 -----------plLCCNFIdnt------dlQIYVGTvq--------------gEILKVdli------------------- 87   baker's yeast
2B4E_A     83 -----------pvLDIAWCphn------dnVIASGSed--------------cTVMVWeipdggl--------------- 116  house mouse
3ACP_A    137 ----------seiTKLKFFps-------geALISSSqd--------------mQLKIWsvk------------------- 166  baker's yeast
3DW8_B     89 -----sleieekiNKIRWLpqkn----aaqFLLSTNd---------------kTIKLWkiserdkrpegynlkeedgryr 144  Norway rat
3GRE_A    113 -----------tvTQITMIpn-------fdAFAVSSkd--------------gQIIVLkvnhyqqes------------- 147  baker's yeast
Feature 1                                                                                     
3FMO_A    131 ----------------eakqqkrPFAYHKLlkda---------ggmVIDMKWNptv----psMVAVCLad-----gSIAV 176  human
1JV2_A    134 ----------------------tKTVEYAPcrsqdidadgqgfcqgGFSIDFTka------dRVLLGGpgsfywqgQLIS 185  human
1K8K_C     84 --------------------rtwKPTLVILrin-----------raARCVRWApn-----ekKFAVGSgs-----rVISI 122  cow
1PEV_A     91 -------------------tthiLKTTIPVfs------------gpVKDISWDse-----skRIAAVGegr---erFGHV 131  nematode
1S4U_X    114 -----------------tkkvifEKLDLLDsdmk---------khsFWALKWGasndrllshRLVATDvk-----gTTYI 162  baker's yeast
1YFQ_A     88 --------------------gspSFQALTNnea----------nlgICRICKYgd------dKLIAASwd-----gLIEV 126  baker's yeast
2B4E_A    117 -----------------vlplrePVITLEGht------------krVGIVAWHpta----qnVLLSAGcd-----nVILV 158  house mouse
3ACP_A    167 --------------------dgsNPRTLIGhr------------atVTDIAIIdr-----grNVLSASld-----gTIRL 204  baker's yeast
3DW8_B    145 dpttvttlrvpvfrpmdlmveasPRRIFANaht-----------yhINSISINsd-----yeTYLSADd------lRINL 202  Norway rat
3GRE_A    148 ---------------evkflnceCIRKINLknfg--------kneyAVRMRAFvne---eksLLVALTnl-----sRVII 196  baker's yeast
Feature 1                                                                                     
3FMO_A    177 LQVtet--------------vkvCAT-LPst--------vaVTSVCWSpk---------------------gkQLAVGKq 212  human
1JV2_A    186 DQVaeivskydp--nvysikynnQLA-TRtaqaif-ddsylGYSVAVGdfng-----------------dgidDFVSGVp 244  human
1K8K_C    123 CYFeqen------------dwwvCKH-IKkpi------rstVLSLDWHpn---------------------svLLAAGSc 162  cow
1PEV_A    132 FLFdtg---------------tsNGN-LTgqa-------raMNSVDFKpsr--------------------pfRIISGSd 168  nematode
1S4U_X    163 WKFhpfadesnsltlnwsptlelQGT-VEspmt----psqfATSVDISer----------------------gLIATGFn 215  baker's yeast
1YFQ_A    127 IDPrnyg-------------dgvIAV-KNlnsnnt-kvknkIFTMDTNs-----------------------sRLIVGMn 168  baker's yeast
2B4E_A    159 WDVgtg---------------aaVLT-LGpdvh-----pdtIYSVDWSrd---------------------gaLICTSCr 196  house mouse
3ACP_A    205 WECgtg---------------ttIHT-FNrken----phdgVNSIALFvgtdrqlheistskknnlefgtygkYVIAGHv 264  baker's yeast
3DW8_B    203 WHLeit---------------drSFNiVDikpanmeeltevITAAEFHpns--------------------cnTFVYSSs 247  Norway rat
3GRE_A    197 FDIrtl---------------erLQI-IEnspr-----hgaVSSICIDee---------------------ccVLILGTt 234  baker's yeast
Feature 1                                                                                     
3FMO_A    213 n-----gTVVQYLPt-------------------lQEkKVIPcppfye-----sdhpvrVLDVLWIgt-----yVFAIVY 258  human
1JV2_A    245 raartlgMVYIYDGkn------------------mSSlYNFTgeqm---------aayfGFSVAATdingddyaDVFIGA 297  human
1K8K_C    163 d-----fKCRIFSAyikeveerpaptpwgskmpfgELmFESSssc------------gwVHGVCFSan----gsRVAWVS 221  cow
1PEV_A    169 d-----nTVAIFEGpp------------------fKFkSTFGeht------------kfVHSVRYNpd----gsLFASTG 209  nematode
1S4U_X    216 n-----gTVQISELst------------------lRPlYNFEsqhsmi------nnsnsIRSVKFSpq----gsLLAIAH 262  baker's yeast
1YFQ_A    169 n-----sQVQWFRLplc---------------eddNG-TIEEsgl-----------kyqIRDVALLpke---qeGYACSS 213  baker's yeast
2B4E_A    197 d-----kRVRVIEPrk------------------gTVvAEKDrphe----------gtrPVHAVFVse-----gKILTTG 238  house mouse
3ACP_A    265 s-----gVITVHNVfs------------------kEQtIQLPskf-----------tcsCNSLTVDgnn---anYIYAGY 307  baker's yeast
3DW8_B    248 k-----gTIRLCDMrasa-------------lcdrHS-KLFEepedpsnrsffseiissISDVKFShs----grYMMTRD 304  Norway rat
3GRE_A    235 r-----gIIDIWDIrf------------------nVLiRSWSfgd-----------hapITHVEVCqfy--gknSVIVVG 278  baker's yeast
Feature 1                                                                                     
3FMO_A    259 aaadgt-----letspDVVMALLpkkee-khpeIF-VNFMepcygs-------------------cterqhHYYLSYIee 312  human
1JV2_A    298 plfmdrgsdgklqevgQVSVSLQras----gdfQT-TKLNgfev-----------------------farfGSAIAPLgd 349  human
1K8K_C    222 hd-------------sTVCLADAdk------kmAV-ATLAset--------------------------lpLLAVTFIte 255  cow
1PEV_A    210 gd-------------gTIVLYNGvd-------gTKtGVFEddslkn-------------------vahsgsVFGLTWSpd 250  nematode
1S4U_X    263 dsn----------sfgCITLYETef-------gERiGSLSvpthssqas-------------lgefahsswVMSLSFNds 312  baker's yeast
1YFQ_A    214 id-------------gRVAVEFFddqgddynssKR-FAFRchrlnlk-----------------dtnlaypVNSIEFSpr 262  baker's yeast
2B4E_A    239 fsrm---------serQVALWDTkh------leEPlSLQEldt-------------------------ssgVLLPFFDpd 278  house mouse
3ACP_A    308 en-------------gMLAQWDLrs------peCPvGEFLine-------------------------gtpINNVYFAa- 342  baker's yeast
3DW8_B    305 y--------------lSVKVWDLnm------enRPvETYQvheylrsklc-----------slyendcifdKFECCWNgs 353  Norway rat
3GRE_A    279 gss-----------ktFLTIWNFvk-------gHCqYAFInsdeqpsmehflpiekgleelnfcgirslnaLSTISVSn- 339  baker's yeast
Feature 1                                                                                     
3FMO_A    313 -----wdLVLAASaa-----stEVSILARqsdqinwe-swlledsSRAElpvtdk------------------------- 356  human
1JV2_A    350 ldqdgfnDIAIAApyggedkkgIVYIFNGrstgl------navpsQILEgqwaar------------------------- 398  human
1K8K_C    256 ------sSLVAAGhd------cFPVLFTYdsaag------klsfgGRLDvpkqssqrgltarerfqnldkkassegsaaa 317  cow
1PEV_A    251 -----gtKIASASad------kTIKIWNVatl----------kveKTIPvgtr--------------------------- 282  nematode
1S4U_X    313 -----geTLCSAGwd------gKLRFWDVktk----------eriTTLNmhcddieieedil----------------av 355  baker's yeast
1YFQ_A    263 -----hkFLYTAGsd------gIISCWNLqtr----------kkiKNFAkfn---------------------------- 293  baker's yeast
2B4E_A    279 -----tnIVYLCGkg-----dsSIRYFEItseap------flhylSMFSsk----------------------------- 313  house mouse
3ACP_A    343 ------gALFVSSgf------dTSIKLDIisdpeserpaiefetpTFLVsnd---------------------------- 382  baker's yeast
3DW8_B    354 -----dsVVMTGSyn------nFFRMFDRntk-----------rdITLEasrennkprtvlkprkvca----sgkrkkde 407  Norway rat
3GRE_A    340 ------dKILLTDea-----tsSIVMFSLnel----------sssKAVIspsrfsdvfiptqvtanltmllrkmkrtsth 398  baker's yeast
Feature 1                                                                         
3FMO_A    357 ------sddslPMGVVVdytnqveitisdektlppaPVLMLlst-----------------dgVLCPF 401  human
1JV2_A    399 -----smppsfGYSMKGatdid----------kngyPDLIVgaf----------------gvdRAILY 435  human
1K8K_C    318 gagldslhknsVSQISVlsgg-----------kakcSQFCTtgm-----------------dgGMSIW 357  cow
1PEV_A    283 -------iedqQLGIIWt-----------------kQALVSisa-----------------ngFINFV 309  nematode
1S4U_X    356 dehgdslaepgVFDVKFlkkgwrs-----gmgadlnESLCCvcl-----------------drSIRWF 401  baker's yeast
1YFQ_A    294 --------edsVVKIACs-----------------dNILCLatsddtfktnaaidqtielnasSIYII 336  baker's yeast
2B4E_A    314 ---------esQRGMGYmpkrgle------vnkceiARFYKlh------------------erKCEPI 348  house mouse
3ACP_A    383 ---------deVSQFCYvsdd------------esnGEVLEvgk-----------------nnFCALY 412  baker's yeast
3DW8_B    408 isvdsldfnkkILHTAWhp---------------keNIIAVat------------------tnNLYIF 442  Norway rat
3GRE_A    399 svddslyhhdiINSISTcev-------------detPLLVAcdn-----------------sgLIGIF 436  baker's yeast

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