1F5N,1DG3


Conserved Protein Domain Family
GBP_C

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cd16269: GBP_C 
Click on image for an interactive view with Cn3D
Guanylate-binding protein, C-terminal domain
Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Statistics
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PSSM-Id: 293879
View PSSM: cd16269
Aligned: 81 rows
Threshold Bit Score: 231.697
Threshold Setting Gi: 573874600
Created: 28-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
coiled coilcoiled coil
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:coiled coil [structural motif]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                         
1F5N_A        290 GPRLESLVLTYVNAISSgdlPCMENAVLALAQIENSAAVQKAIAHYEQQMGQkv--qLPTESlQELLDLHRDSEREAIEV 367  human
EGW12737      290 GARLKSLVVTHVNTICSgslPCIENAVLALSQTENAAAVQKAIAHYDQQMSQkl--qLPTETlQELMNLHRASEKEAIKI 367  Chinese hamster
XP_006270329  288 GQMLGSLVQCYVETLRSgkvPCMDNAVVALAAIENEAAVQEGLAHYISQMKQl---kFPVDQ-EELSEKHGESMAGALGV 363  American alli...
XP_006270342  288 GRMFSSLVQNYVKTIRSgkvPCIDNTVIALAATENEAAITAALAHYEAEMRKl---qLPVEL-DKLLEAHGKCEEGALKL 363  American alli...
AHN82530      288 GSMFCRLVETYVDTIQSgdiPCMERAIDAMAKIENTKAVQAALDHYKTRMQAsv--qLPTNFaDELSRVHLTCDREAIEI 365  Hyriopsis cum...
XP_007664049  239 GKKFGGLVQSYVEMIRSgtlPCLENAVISLAKIENGEAVRGALAIYDHELQGv---sLPIER-DLLSEQHRKAEKEALAY 314  platypus
XP_008174576  282 GRRFGSLVQSYVGTIRSgrvPCLDNAVTAMASIENEAALREALAHYAAGMGGl---rLPAEL-AELSAAHGTHEADALRL 357  western paint...
XP_012657078  289 GNRLGTLVATYVEAINSgsvPCLENAVTTLAQRENAAALQRAADHYRQQMAQrv--rLPTDTlQELLDAHTACEREALAV 366  small-eared g...
XP_013400986  292 GRRYVALAETYVQAINSgavPCIGTAVETMMQVECQRALEESVKHYRKTMEKttvpnMPLFL-HELSSLHEQANEEALRV 370  Lingula anatina
XP_013400986  922 GRRLLQLAQSYVGAINDgavPCVQSAVTVMGRNECERAIDLASNAYMEEMDNalgkaLPVDI-RVLSEKHKSASDSAVKL 1000 Lingula anatina
Feature 1                                                                                         
1F5N_A        368 FIRSsfkd----------------vdhlFQKELAAQLEKKRDDFCKQNQEASSDRCSGLLQVIFSP-----LEEEVKAGI 426  human
EGW12737      368 FMDNsfkdvnqvfmtqlvaeevlqrflqSKDDVTDAILQTDQELTEKQKEIEVEHMKAEAEEATAK-----IREEMQQKI 442  Chinese hamster
XP_006270329  364 FMDRsfkd----------------egqkYLQKLKDGIKENYGKLLGKNEVASKDACFALLEELSAP-----MQKRLGDNV 422  American alli...
XP_006270342  364 FMEHsfrd----------------seqqYQKQLVVGIAEQRGNILAQNEDVSKEICLALLEELPAP-----MKKNLSDGV 422  American alli...
AHN82530      366 FMSMsild----------------ekqeSQKKLQDYIEEEYERFCDLNRRASKEKCRHILTELTTP-----LSQNMAEGM 424  Hyriopsis cum...
XP_007664049  315 FMKKsfkd----------------qggkCQAELMAGIGQRYYSLLDKNEAASIQVCQDLLAHLVQT-----LERELSQGG 373  platypus
XP_008174576  358 FMQRsfkd----------------eeqeFQKQLVAGITERYADVLAENEAVSEQTCRALLEELSAA-----MQQKLSAGL 416  western paint...
XP_012657078  367 FMEHsfkdehqef------qkqlwanevLQSFLKQQVVIEESILHSDKALTAGEKVTAEERAKREEtekemLVQRQKQEE 440  small-eared g...
XP_013400986  371 YKGIavfd----------------aegiFHTKLQEQLLSIYDDFVQKNKEASRKKCKSILQNAYAD-----IASNIQAGH 429  Lingula anatina
XP_013400986 1001 YHANamld----------------sdgqYSQKLQDALDNCYRVYTEKNWQASVQKCDLLLKALVQEs----LKPKLDEAA 1060 Lingula anatina
Feature 1                                                                                         
1F5N_A        427 Ys-----kPGGYRLFVQKLQDLKKKyyeeprkgiqaeEILQTYLKSKESMTDAILQTDqtl---teKEKEIEVERVKAES 498  human
EGW12737      443 Ekll-kqkEKSHKKHMKQLTEMMEKgqgrm---remqQRNEQLLQEKEKCHEEHMKQLtek--mekAQYRMSKMEEKIEQ 516  Chinese hamster
XP_006270329  423 Yn-----qPGGYEAYIRDRNQVVEDfrkkpkngvkveDVLEQFLASKKAEAEAVLKFDtli---tdMEKHLADGKQKAEL 494  American alli...
XP_006270342  423 Ys-----rPGGYGVYKADLSQVVEGywgkpnkgvkveEVLDQFLAKMQPEAAAVLKVDtklteaekHIVDEKQKAEVWSS 497  American alli...
AHN82530      425 Yn-----kPGGYQEYIRDRERALLQyrqvpgkgimaeDALGEFLRERDSEAEAILASDqal---teAERKRAEEERSAEI 496  Hyriopsis cum...
XP_007664049  374 Yt-----rPGGYELYKAERDRVVERfrkspnkgvkaeEVLQEFLAKREAEGRAVLQADqnl---tqAQKQVAEESARAEQ 445  platypus
XP_008174576  417 Ys-----qPGGYQAYDRDQTQVVENyrakpnkgvkaeEALEQFLAGKKAEAEAVLKADnll---teAEKHVAEEKQKAEM 488  western paint...
XP_012657078  441 LeqnmqaqERNYAEHIAQLKKKMEEeke------nhkRNYEMMLEQQQKIQTYLLKEGf-------KERSEEMTKVIEHL 507  small-eared g...
XP_013400986  430 Ya-----vKGGYKKYQADYQKVKEIyantqrkgpcadEELARFNEAKICEGKAIMTADkam---sqKEKDLAEAREKQQQ 501  Lingula anatina
XP_013400986 1061 Fs-----vSGGYEKYRGEIDTIVMKfersegkgpaaeELLAKFLAEKQDQEEAILAGDkam---tkMDREKAEVEEEAKR 1132 Lingula anatina
Feature 1                                                           ############                  
1F5N_A        499 AQASAKMLHEMQRKNEQMMEQKERSYQEHLKQLTEKMENDRVQLLKEQERTLALKLQEQEQLlkeg---fqkeSRIMKNE 575  human
EGW12737      517 LLQQTKSYEELRKQLTEKTEEARVQMREMQEKFKKLLQQKDNNHAKLMKELTENLLNAQKVYkkv------cqVLKLLKL 590  Chinese hamster
XP_006270329  495 LEQQRRAEEERRLRAEQLVKDQERSFQEYQRQLEAKLAEEAATMKKEAQKALECKLKEQGELlqqg---frekSMLMEQE 571  American alli...
XP_006270342  498 RRRQRRRRGCRWMTKRMLMKDQERSYEENLKQLKAKMKDEAERVRKEAAQVLEYRLKEQEAIlskg---ftkqMELMQEE 574  American alli...
AHN82530      497 SEQKARAAEEERMRQEQLQQDQLESYQRNLELLQQKMLDEKKNLIAENERLLEQKLQEQERAvkde---lekvVQPREQE 573  Hyriopsis cum...
XP_007664049  446 VEQQWLMEEEKRRQAEQLLKDQEQSHQENLQQLQSKMEEEARRIREEASHALESRLQEQEKLlrmg---feekSQSMKEE 522  platypus
XP_008174576  489 LEQQRKVAEEKRLQTEQLMKDQERSHQENVKQLEAKVVEELASARQEAERAMESKLREQEAMmqkg---faekARLMEDE 565  western paint...
XP_012657078  508 KEKTQPSKNEDNRFSGMVDTAVQALIHHFVTRGVSKGQKNTLDMASGINMTGPVCLVENTNGklsvggealeiLSAIKQP 587  small-eared g...
XP_013400986  502 EALRSKSLEEQQVQLQQQLIDKEKSNLAMMQKVQAEFDEKIRATQERHEEDIRTKDEEHQRLlqeg---lhtqAEQHKEM 578  Lingula anatina
XP_013400986 1133 QAADAAAKSREAEMLKQQLLDVENSMQTNMTMLKGEFEKKLQETEAGYKALLAKRQAEHEELlkse---lktqAQLLEKS 1209 Lingula anatina
Feature 1              
1F5N_A        576 IQDLQ 580  human
EGW12737      591 FSSFK 595  Chinese hamster
XP_006270329  572 ISTLK 576  American alligator
XP_006270342  575 IEERD 579  American alligator
AHN82530      574 IRDLR 578  Hyriopsis cumingii
XP_007664049  523 LEKLQ 527  platypus
XP_008174576  566 ISGLR 570  western painted turtle
XP_012657078  588 VVVVA 592  small-eared galago
XP_013400986  579 LDEMR 583  Lingula anatina
XP_013400986 1210 IKDVK 1214 Lingula anatina

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