Conserved Protein Domain Family
OCRE_RBM5
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cd16168: OCRE_RBM5 
OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
RBM5 is also called protein G15, H37, putative tumor suppressor LUCA15, or renal carcinoma antigen NY-REN-9. It is a known modulator of apoptosis. It acts as a tumor suppressor or an RNA splicing factor. RBM5 shows high sequence similarity to RNA-binding protein 6 (RBM6 or NY-LU-12 or g16 or DEF-3). Both of them specifically binds poly(G) RNA. RBM5 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain.
Links
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Statistics
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PSSM-Id: 293887
Aligned: 5 rows
Threshold Bit Score: 134.078
Created: 19-Jun-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:OCRE repeat 1 [structural motif]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             ########                                           
P52756       455 AVPDTSTYQYDESSGYYYDPTTGLYYDPNSQYYYNSLTQQYLYWDGEKETYVPAAE 510 human
XP_007052738 458 AVPDTSTYQYDESSGYYYDPITGLYYDPNSQYYYNALTQQYLYWDGEKETYMPAAE 513 green sea turtle
A4IGK4       471 SVPDTSTYQYDESSGYYYDPQTGLYYDPNSQYYYNSLTQQYLYWDGEKQTYLPAAD 526 western clawed frog
NP_001093608 478 NVPDTSSYQYDESSGYYYDPITGLYYDPNTQYYYNSQTQQYLYWDGEKQAYLPAVD 533 zebrafish
XP_005996382 417 AVPDTSTYQYDESSGYYYDPQTGLYYDPNSQYYYNAQTQQYLYWDGEKQTYIPATE 472 coelacanth

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